Design, syntheses, and activity of new 3-[(sulfonylaryl)-amino]-1,4-benzodiazepin-2-one derivatives as α-thrombin inhibitors

European Journal of Medicinal Chemistry

Volumn 33, Issue 6, 1998, Pages 471-488

  Dumas, Daniel ^a   Leclerc, Gérard ^a   Baldwin, John J ^b,c   Lewis, S Dale ^b   Murcko, Mark ^b,d   Naylor Olsen, Adel M ^b  

^a Laboratoire de Pharmacochimie   (France)

^b MERCK RESEARCH LABORATORIES   (United States)

^c PHARMACOPEIA INC   (United States)

^d VERTEX PHARMACEUTICALS   (United States)

Author keywords

Argatroban; Benzodiazepinones; Molecular modeling; Thrombin inhibitors

Indexed keywords

ANTICOAGULANT AGENT; ARGATROBAN; BENZODIAZEPINE DERIVATIVE; THROMBIN INHIBITOR;

ARTICLE; DRUG DESIGN; ENZYME INHIBITION; INFRARED SPECTROPHOTOMETRY; MASS SPECTROMETRY; MOLECULAR MODEL; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; QUANTUM CHEMISTRY; STRUCTURE ACTIVITY RELATION; THROMBOCYTE AGGREGATION; THROMBOSIS;

EID: 0032097752     PISSN: 02235234     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0223-5234(98)80048-2     Document Type: Article

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