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Volumn 72, Issue 2, 1998, Pages 189-219

Psychiatry's Holy Grail: The Search for the Mechanisms of Mental Diseases

(1)  Grob, Gerald N a  

a NONE

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; HISTORY; HUMAN; MENTAL DISEASE; PSYCHIATRY; UNITED STATES;

EID: 0032090202     PISSN: 00075140     EISSN: None     Source Type: Journal    
DOI: 10.1353/bhm.1998.0094     Document Type: Conference Paper
Times cited : (35)

References (144)
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    • 1838; reissued Cambridge: Harvard University Press
    • Isaac Ray, A Treatise on the Medical Jurisprudence of Insanity (1838; reissued Cambridge: Harvard University Press, 1962), p. 60. See also Gerald N. Grob, "Origins of DSM-I: A Study in Appearance and Reality," Amer. J. Psychiatry, 1991, 148: 421-31.
    • (1962) A Treatise on the Medical Jurisprudence of Insanity , pp. 60
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    • Isaac Ray, A Treatise on the Medical Jurisprudence of Insanity (1838; reissued Cambridge: Harvard University Press, 1962), p. 60. See also Gerald N. Grob, "Origins of DSM-I: A Study in Appearance and Reality," Amer. J. Psychiatry, 1991, 148: 421-31.
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    • Worcester State Lunatic Hospital, Annual Report, 1839, 7: 72. See also ibid., 1841, 9: 40-41; 1842, 10: 39; 1845, 13: 50-51; and Samuel B. Woodward, "Observations on the Medical Treatment of Insanity," Amer. J. Insan., 1850, 7: 1-34.
    • (1839) Annual Report , vol.7 , pp. 72
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    • Worcester State Lunatic Hospital, Annual Report, 1839, 7: 72. See also ibid., 1841, 9: 40-41; 1842, 10: 39; 1845, 13: 50-51; and Samuel B. Woodward, "Observations on the Medical Treatment of Insanity," Amer. J. Insan., 1850, 7: 1-34.
    • (1841) Annual Report , vol.9 , pp. 40-41
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    • Worcester State Lunatic Hospital, Annual Report, 1839, 7: 72. See also ibid., 1841, 9: 40-41; 1842, 10: 39; 1845, 13: 50-51; and Samuel B. Woodward, "Observations on the Medical Treatment of Insanity," Amer. J. Insan., 1850, 7: 1-34.
    • (1842) Annual Report , vol.10 , pp. 39
  • 14
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    • Worcester State Lunatic Hospital, Annual Report, 1839, 7: 72. See also ibid., 1841, 9: 40-41; 1842, 10: 39; 1845, 13: 50-51; and Samuel B. Woodward, "Observations on the Medical Treatment of Insanity," Amer. J. Insan., 1850, 7: 1-34.
    • (1845) Annual Report , vol.13 , pp. 50-51
  • 15
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    • Worcester State Lunatic Hospital, Annual Report, 1839, 7: 72. See also ibid., 1841, 9: 40-41; 1842, 10: 39; 1845, 13: 50-51; and Samuel B. Woodward, "Observations on the Medical Treatment of Insanity," Amer. J. Insan., 1850, 7: 1-34.
    • (1850) Amer. J. Insan. , vol.7 , pp. 1-34
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    • Pliny Earle to Clark Bell (copy), 16 April 1886, Earle Papers, American Antiquarian Society, Worcester, Mass. (emphasis in original)
    • Pliny Earle to Clark Bell (copy), 16 April 1886, Earle Papers, American Antiquarian Society, Worcester, Mass. (emphasis in original).
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    • On the Supposed Increase of Insanity
    • For typical examples of etiological thinking, see Edward Jarvis, "On the Supposed Increase of Insanity," Amer. J. Insan., 1852, 8: 333-64; and idem, "The Production of Vital Force," Med. Commun. Massachusetts Med. Soc., 2d ser., 1854, 4: 1-40. A general discussion can be found in Gerald N. Grob, Mental Institutions in America: Social Policy to 1875 (New York: Free Press, 1973), pp. 155-65.
    • (1852) Amer. J. Insan. , vol.8 , pp. 333-364
    • Jarvis, E.1
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    • The Production of Vital Force
    • For typical examples of etiological thinking, see Edward Jarvis, "On the Supposed Increase of Insanity," Amer. J. Insan., 1852, 8: 333-64; and idem, "The Production of Vital Force," Med. Commun. Massachusetts Med. Soc., 2d ser., 1854, 4: 1-40. A general discussion can be found in Gerald N. Grob, Mental Institutions in America: Social Policy to 1875 (New York: Free Press, 1973), pp. 155-65.
    • (1854) Med. Commun. Massachusetts Med. Soc., 2d Ser. , vol.4 , pp. 1-40
    • Jarvis, E.1
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    • New York: Free Press
    • For typical examples of etiological thinking, see Edward Jarvis, "On the Supposed Increase of Insanity," Amer. J. Insan., 1852, 8: 333-64; and idem, "The Production of Vital Force," Med. Commun. Massachusetts Med. Soc., 2d ser., 1854, 4: 1-40. A general discussion can be found in Gerald N. Grob, Mental Institutions in America: Social Policy to 1875 (New York: Free Press, 1973), pp. 155-65.
    • (1973) Mental Institutions in America: Social Policy to 1875 , pp. 155-165
    • Grob, G.N.1
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    • Brigham, Inquiry (n. 6), p. 288; Worcester State Lunatic Hospital, Annual Report, 1840, 8: 71-72.
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    • Grob, Mental Institutions (n. 11), pp. 243-55; Gerald N. Grob, Mental Illness and American Society, 1875-1940 (Princeton: Princeton University Press, 1983), pp. 38, 220-21; Peter McCandless, Moonlight, Magnolias, and Madness: Insanity in South Carolina from the Colonial Period to the Progressive Era (Chapel Hill: University of North Carolina Press, 1996), pp. 151-59; John S. Hughes, "Labeling and Treating Black Mental Illness in Alabama, 1861-1910," J. Southern Hist., 1992, 58: 435-60.
    • Mental Institutions , Issue.11 , pp. 243-255
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    • Grob, Mental Institutions (n. 11), pp. 243-55; Gerald N. Grob, Mental Illness and American Society, 1875-1940 (Princeton: Princeton University Press, 1983), pp. 38, 220-21; Peter McCandless, Moonlight, Magnolias, and Madness: Insanity in South Carolina from the Colonial Period to the Progressive Era (Chapel Hill: University of North Carolina Press, 1996), pp. 151-59; John S. Hughes, "Labeling and Treating Black Mental Illness in Alabama, 1861-1910," J. Southern Hist., 1992, 58: 435-60.
    • (1983) Mental Illness and American Society, 1875-1940 , pp. 38
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    • Chapel Hill: University of North Carolina Press
    • Grob, Mental Institutions (n. 11), pp. 243-55; Gerald N. Grob, Mental Illness and American Society, 1875-1940 (Princeton: Princeton University Press, 1983), pp. 38, 220-21; Peter McCandless, Moonlight, Magnolias, and Madness: Insanity in South Carolina from the Colonial Period to the Progressive Era (Chapel Hill: University of North Carolina Press, 1996), pp. 151-59; John S. Hughes, "Labeling and Treating Black Mental Illness in Alabama, 1861-1910," J. Southern Hist., 1992, 58: 435-60.
    • (1996) Moonlight, Magnolias, and Madness: Insanity in South Carolina from the Colonial Period to the Progressive Era , pp. 151-159
    • McCandless, P.1
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    • Labeling and Treating Black Mental Illness in Alabama, 1861-1910
    • Grob, Mental Institutions (n. 11), pp. 243-55; Gerald N. Grob, Mental Illness and American Society, 1875-1940 (Princeton: Princeton University Press, 1983), pp. 38, 220-21; Peter McCandless, Moonlight, Magnolias, and Madness: Insanity in South Carolina from the Colonial Period to the Progressive Era (Chapel Hill: University of North Carolina Press, 1996), pp. 151-59; John S. Hughes, "Labeling and Treating Black Mental Illness in Alabama, 1861-1910," J. Southern Hist., 1992, 58: 435-60.
    • (1992) J. Southern Hist. , vol.58 , pp. 435-460
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  • 32
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    • The Incidence of Mental Disease in the Negro
    • See E. Y. Williams, "The Incidence of Mental Disease in the Negro," J. Negro Educ., 1937, 6: 377-92; Philip S. Wagner, "A Comparative Study of Negro and White Admissions to the Psychiatric Pavilion of the Cincinnati General Hospital," Amer. J. Psychiatry, 1938, 95: 167-83; J. E. Greene, "Analysis of Racial Differences within Seven Clinical Categories of White and Negro Mental Patients in the Georgia State Hospital, 1923-32," Soc. Forces, 1938, 17: 201-11; and J. E. Greene and W. S. Phillips, "Racial and Regional Differences in Standard Therapy Rates among White and Negro Mental Patients," Hum. Biol., 1939, 11: 513-28. The rise of psychiatric epidemiology tended to create more interest in racial and ethnic categories. Benjamin Malzberg, a pioneer in the field, found higher rates of mental disorders among blacks than among whites. He speculated that higher rates of general paresis and alcoholic psychoses might be explained in historical terms. It was difficult, however, to account for dementia praecox (i.e., schizophrenia) and manic-depressive psychosis in terms of environment. He noted that blacks had a "more emotional make-up," as was evidenced by their music (Benjamin Malzberg, "Mental Disease among Negroes in New York State," Hum. Biol., 1935, 7: 471-513, quotation on p. 510). "Given such emotional instability," he added, "it is likely that there is a fruitful ground for functional mental disorders" (ibid.).
    • (1937) J. Negro Educ. , vol.6 , pp. 377-392
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    • A Comparative Study of Negro and White Admissions to the Psychiatric Pavilion of the Cincinnati General Hospital
    • See E. Y. Williams, "The Incidence of Mental Disease in the Negro," J. Negro Educ., 1937, 6: 377-92; Philip S. Wagner, "A Comparative Study of Negro and White Admissions to the Psychiatric Pavilion of the Cincinnati General Hospital," Amer. J. Psychiatry, 1938, 95: 167-83; J. E. Greene, "Analysis of Racial Differences within Seven Clinical Categories of White and Negro Mental Patients in the Georgia State Hospital, 1923-32," Soc. Forces, 1938, 17: 201-11; and J. E. Greene and W. S. Phillips, "Racial and Regional Differences in Standard Therapy Rates among White and Negro Mental Patients," Hum. Biol., 1939, 11: 513-28. The rise of psychiatric epidemiology tended to create more interest in racial and ethnic categories. Benjamin Malzberg, a pioneer in the field, found higher rates of mental disorders among blacks than among whites. He speculated that higher rates of general paresis and alcoholic psychoses might be explained in historical terms. It was difficult, however, to account for dementia praecox (i.e., schizophrenia) and manic-depressive psychosis in terms of environment. He noted that blacks had a "more emotional make-up," as was evidenced by their music (Benjamin Malzberg, "Mental Disease among Negroes in New York State," Hum. Biol., 1935, 7: 471-513, quotation on p. 510). "Given such emotional instability," he added, "it is likely that there is a fruitful ground for functional mental disorders" (ibid.).
    • (1938) Amer. J. Psychiatry , vol.95 , pp. 167-183
    • Wagner, P.S.1
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    • Analysis of Racial Differences within Seven Clinical Categories of White and Negro Mental Patients in the Georgia State Hospital, 1923-32
    • See E. Y. Williams, "The Incidence of Mental Disease in the Negro," J. Negro Educ., 1937, 6: 377-92; Philip S. Wagner, "A Comparative Study of Negro and White Admissions to the Psychiatric Pavilion of the Cincinnati General Hospital," Amer. J. Psychiatry, 1938, 95: 167-83; J. E. Greene, "Analysis of Racial Differences within Seven Clinical Categories of White and Negro Mental Patients in the Georgia State Hospital, 1923-32," Soc. Forces, 1938, 17: 201-11; and J. E. Greene and W. S. Phillips, "Racial and Regional Differences in Standard Therapy Rates among White and Negro Mental Patients," Hum. Biol., 1939, 11: 513-28. The rise of psychiatric epidemiology tended to create more interest in racial and ethnic categories. Benjamin Malzberg, a pioneer in the field, found higher rates of mental disorders among blacks than among whites. He speculated that higher rates of general paresis and alcoholic psychoses might be explained in historical terms. It was difficult, however, to account for dementia praecox (i.e., schizophrenia) and manic-depressive psychosis in terms of environment. He noted that blacks had a "more emotional make-up," as was evidenced by their music (Benjamin Malzberg, "Mental Disease among Negroes in New York State," Hum. Biol., 1935, 7: 471-513, quotation on p. 510). "Given such emotional instability," he added, "it is likely that there is a fruitful ground for functional mental disorders" (ibid.).
    • (1938) Soc. Forces , vol.17 , pp. 201-211
    • Greene, J.E.1
  • 35
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    • Racial and Regional Differences in Standard Therapy Rates among White and Negro Mental Patients
    • See E. Y. Williams, "The Incidence of Mental Disease in the Negro," J. Negro Educ., 1937, 6: 377-92; Philip S. Wagner, "A Comparative Study of Negro and White Admissions to the Psychiatric Pavilion of the Cincinnati General Hospital," Amer. J. Psychiatry, 1938, 95: 167-83; J. E. Greene, "Analysis of Racial Differences within Seven Clinical Categories of White and Negro Mental Patients in the Georgia State Hospital, 1923-32," Soc. Forces, 1938, 17: 201-11; and J. E. Greene and W. S. Phillips, "Racial and Regional Differences in Standard Therapy Rates among White and Negro Mental Patients," Hum. Biol., 1939, 11: 513-28. The rise of psychiatric epidemiology tended to create more interest in racial and ethnic categories. Benjamin Malzberg, a pioneer in the field, found higher rates of mental disorders among blacks than among whites. He speculated that higher rates of general paresis and alcoholic psychoses might be explained in historical terms. It was difficult, however, to account for dementia praecox (i.e., schizophrenia) and manic-depressive psychosis in terms of environment. He noted that blacks had a "more emotional make-up," as was evidenced by their music (Benjamin Malzberg, "Mental Disease among Negroes in New York State," Hum. Biol., 1935, 7: 471-513, quotation on p. 510). "Given such emotional instability," he added, "it is likely that there is a fruitful ground for functional mental disorders" (ibid.).
    • (1939) Hum. Biol. , vol.11 , pp. 513-528
    • Greene, J.E.1    Phillips, W.S.2
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    • See E. Y. Williams, "The Incidence of Mental Disease in the Negro," J. Negro Educ., 1937, 6: 377-92; Philip S. Wagner, "A Comparative Study of Negro and White Admissions to the Psychiatric Pavilion of the Cincinnati General Hospital," Amer. J. Psychiatry, 1938, 95: 167-83; J. E. Greene, "Analysis of Racial Differences within Seven Clinical Categories of White and Negro Mental Patients in the Georgia State Hospital, 1923-32," Soc. Forces, 1938, 17: 201-11; and J. E. Greene and W. S. Phillips, "Racial and Regional Differences in Standard Therapy Rates among White and Negro Mental Patients," Hum. Biol., 1939, 11: 513-28. The rise of psychiatric epidemiology tended to create more interest in racial and ethnic categories. Benjamin Malzberg, a pioneer in the field, found higher rates of mental disorders among blacks than among whites. He speculated that higher rates of general paresis and alcoholic psychoses might be explained in historical terms. It was difficult, however, to account for dementia praecox (i.e., schizophrenia) and manic-depressive psychosis in terms of environment. He noted that blacks had a "more emotional make-up," as was evidenced by their music (Benjamin Malzberg, "Mental Disease among Negroes in New York State," Hum. Biol., 1935, 7: 471-513, quotation on p. 510). "Given such emotional instability," he added, "it is likely that there is a fruitful ground for functional mental disorders" (ibid.).
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    • John P. Gray's thinking is revealed in a number of his articles, including "Insanity and Its Relation to Medicine," Amer. J. Insan., 1868, 25: 145-72; "The Dependence of Insanity on Physical Disease," ibid., 1871, 27: 377-408; "Pathology of Insanity," ibid., 1874, 31: 1-29; "General View of Insanity," ibid., 1875, 31: 443-65; and "Heredity," ibid., 1884, 41: 1-21. For secondary accounts see Rosenberg, Trial (n. 24); and Robert J. Waldinger, "Sleep of Reason: John P. Gray and the Challenge of Moral Insanity," J. Hist. Med. Allied Sci., 1979, 34: 163-79. Also useful is Gary S. Belkin, "Moral Insanity, Science and Religion in Nineteenth-Century America: The Gray-Ray Debate," Hist. Psychiatry, 1996, 7: 591-613.
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    • John P. Gray's thinking is revealed in a number of his articles, including "Insanity and Its Relation to Medicine," Amer. J. Insan., 1868, 25: 145-72; "The Dependence of Insanity on Physical Disease," ibid., 1871, 27: 377-408; "Pathology of Insanity," ibid., 1874, 31: 1-29; "General View of Insanity," ibid., 1875, 31: 443-65; and "Heredity," ibid., 1884, 41: 1-21. For secondary accounts see Rosenberg, Trial (n. 24); and Robert J. Waldinger, "Sleep of Reason: John P. Gray and the Challenge of Moral Insanity," J. Hist. Med. Allied Sci., 1979, 34: 163-79. Also useful is Gary S. Belkin, "Moral Insanity, Science and Religion in Nineteenth-Century America: The Gray-Ray Debate," Hist. Psychiatry, 1996, 7: 591-613.
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    • John P. Gray's thinking is revealed in a number of his articles, including "Insanity and Its Relation to Medicine," Amer. J. Insan., 1868, 25: 145-72; "The Dependence of Insanity on Physical Disease," ibid., 1871, 27: 377-408; "Pathology of Insanity," ibid., 1874, 31: 1-29; "General View of Insanity," ibid., 1875, 31: 443-65; and "Heredity," ibid., 1884, 41: 1-21. For secondary accounts see Rosenberg, Trial (n. 24); and Robert J. Waldinger, "Sleep of Reason: John P. Gray and the Challenge of Moral Insanity," J. Hist. Med. Allied Sci., 1979, 34: 163-79. Also useful is Gary S. Belkin, "Moral Insanity, Science and Religion in Nineteenth-Century America: The Gray-Ray Debate," Hist. Psychiatry, 1996, 7: 591-613.
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    • John P. Gray's thinking is revealed in a number of his articles, including "Insanity and Its Relation to Medicine," Amer. J. Insan., 1868, 25: 145-72; "The Dependence of Insanity on Physical Disease," ibid., 1871, 27: 377-408; "Pathology of Insanity," ibid., 1874, 31: 1-29; "General View of Insanity," ibid., 1875, 31: 443-65; and "Heredity," ibid., 1884, 41: 1-21. For secondary accounts see Rosenberg, Trial (n. 24); and Robert J. Waldinger, "Sleep of Reason: John P. Gray and the Challenge of Moral Insanity," J. Hist. Med. Allied Sci., 1979, 34: 163-79. Also useful is Gary S. Belkin, "Moral Insanity, Science and Religion in Nineteenth-Century America: The Gray-Ray Debate," Hist. Psychiatry, 1996, 7: 591-613.
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    • John P. Gray's thinking is revealed in a number of his articles, including "Insanity and Its Relation to Medicine," Amer. J. Insan., 1868, 25: 145-72; "The Dependence of Insanity on Physical Disease," ibid., 1871, 27: 377-408; "Pathology of Insanity," ibid., 1874, 31: 1-29; "General View of Insanity," ibid., 1875, 31: 443-65; and "Heredity," ibid., 1884, 41: 1-21. For secondary accounts see Rosenberg, Trial (n. 24); and Robert J. Waldinger, "Sleep of Reason: John P. Gray and the Challenge of Moral Insanity," J. Hist. Med. Allied Sci., 1979, 34: 163-79. Also useful is Gary S. Belkin, "Moral Insanity, Science and Religion in Nineteenth-Century America: The Gray-Ray Debate," Hist. Psychiatry, 1996, 7: 591-613.
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    • John P. Gray's thinking is revealed in a number of his articles, including "Insanity and Its Relation to Medicine," Amer. J. Insan., 1868, 25: 145-72; "The Dependence of Insanity on Physical Disease," ibid., 1871, 27: 377-408; "Pathology of Insanity," ibid., 1874, 31: 1-29; "General View of Insanity," ibid., 1875, 31: 443-65; and "Heredity," ibid., 1884, 41: 1-21. For secondary accounts see Rosenberg, Trial (n. 24); and Robert J. Waldinger, "Sleep of Reason: John P. Gray and the Challenge of Moral Insanity," J. Hist. Med. Allied Sci., 1979, 34: 163-79. Also useful is Gary S. Belkin, "Moral Insanity, Science and Religion in Nineteenth-Century America: The Gray-Ray Debate," Hist. Psychiatry, 1996, 7: 591-613.
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    • John P. Gray's thinking is revealed in a number of his articles, including "Insanity and Its Relation to Medicine," Amer. J. Insan., 1868, 25: 145-72; "The Dependence of Insanity on Physical Disease," ibid., 1871, 27: 377-408; "Pathology of Insanity," ibid., 1874, 31: 1-29; "General View of Insanity," ibid., 1875, 31: 443-65; and "Heredity," ibid., 1884, 41: 1-21. For secondary accounts see Rosenberg, Trial (n. 24); and Robert J. Waldinger, "Sleep of Reason: John P. Gray and the Challenge of Moral Insanity," J. Hist. Med. Allied Sci., 1979, 34: 163-79. Also useful is Gary S. Belkin, "Moral Insanity, Science and Religion in Nineteenth-Century America: The Gray-Ray Debate," Hist. Psychiatry, 1996, 7: 591-613.
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    • John P. Gray's thinking is revealed in a number of his articles, including "Insanity and Its Relation to Medicine," Amer. J. Insan., 1868, 25: 145-72; "The Dependence of Insanity on Physical Disease," ibid., 1871, 27: 377-408; "Pathology of Insanity," ibid., 1874, 31: 1-29; "General View of Insanity," ibid., 1875, 31: 443-65; and "Heredity," ibid., 1884, 41: 1-21. For secondary accounts see Rosenberg, Trial (n. 24); and Robert J. Waldinger, "Sleep of Reason: John P. Gray and the Challenge of Moral Insanity," J. Hist. Med. Allied Sci., 1979, 34: 163-79. Also useful is Gary S. Belkin, "Moral Insanity, Science and Religion in Nineteenth-Century America: The Gray-Ray Debate," Hist. Psychiatry, 1996, 7: 591-613.
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    • Edward Cowles, "The Advancement of Psychiatry in America," ibid., 1896, 52: 364-86, quotation on p. 376.
    • (1896) Amer. J. Insan. , vol.52 , pp. 364-386
    • Cowles, E.1
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    • The Relation of Mental Diseases to General Medicine
    • Ibid. See also Edward Cowles, "The Relation of Mental Diseases to General Medicine," Boston Med. Surg. J., 1897, 137: 277-82.
    • (1897) Boston Med. Surg. J. , vol.137 , pp. 277-282
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    • Presidential Address
    • Peter M. Wise, "Presidential Address," Amer. J. Insan., 1901, 58: 79.
    • (1901) Amer. J. Insan. , vol.58 , pp. 79
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    • A Short Sketch of the Problems of Psychiatry
    • Adolf Meyer, "A Short Sketch of the Problems of Psychiatry," Amer. J. Insan., 1896-97, 53, reprinted in The Collected Papers of Adolf Meyer, ed. Eunice Winters, 4 vols. (Baltimore: Johns Hopkins Press, 1950-52), 2: 273-82, quotation on p. 274.
    • (1896) Amer. J. Insan. , vol.53
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    • reprinted in ed. Eunice Winters, 4 vols. Baltimore: Johns Hopkins Press
    • Adolf Meyer, "A Short Sketch of the Problems of Psychiatry," Amer. J. Insan., 1896- 97, 53, reprinted in The Collected Papers of Adolf Meyer, ed. Eunice Winters, 4 vols. (Baltimore: Johns Hopkins Press, 1950-52), 2: 273-82, quotation on p. 274.
    • (1950) Collected Papers of Adolf Meyer , vol.2 , pp. 273-282
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    • Adolf Meyer, "Objective Psychology or Psychobiology with Subordination of the Medically Useless Contrast of Mental and Physical," JAMA, 1915, 65: 860-63, reprinted in Collected Papers (n. 38), 3: 38-43, quotation on p. 41.
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    • reprinted in
    • Adolf Meyer, "Objective Psychology or Psychobiology with Subordination of the Medically Useless Contrast of Mental and Physical," JAMA, 1915, 65: 860-63, reprinted in Collected Papers (n. 38), 3: 38-43, quotation on p. 41.
    • Collected Papers , vol.3 , Issue.38 , pp. 38-43
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    • Organization of Eugenics Investigation
    • Adolf Meyer, "Organization of Eugenics Investigation," Eugen. News, 1917, 2, in Collected Papers (n. 38), 4: 304.
    • (1917) Eugen. News , vol.2
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    • Adolf Meyer, "Organization of Eugenics Investigation," Eugen. News, 1917, 2, in Collected Papers (n. 38), 4: 304.
    • Collected Papers , vol.4 , Issue.38 , pp. 304
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    • A Review of the Signs of Degeneration and of Methods of Registration
    • Adolf Meyer, "A Review of the Signs of Degeneration and of Methods of Registration," Amer. J. Insan., 1895-96, 52, in Collected Papers, 2: 257. See also idem, "Short Sketch" (n. 38), p. 279.
    • (1895) Amer. J. Insan. , vol.52
    • Meyer, A.1
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    • Adolf Meyer, "A Review of the Signs of Degeneration and of Methods of Registration," Amer. J. Insan., 1895-96, 52, in Collected Papers, 2: 257. See also idem, "Short Sketch" (n. 38), p. 279.
    • Collected Papers , vol.2 , pp. 257
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    • Adolf Meyer, "A Review of the Signs of Degeneration and of Methods of Registration," Amer. J. Insan., 1895-96, 52, in Collected Papers, 2: 257. See also idem, "Short Sketch" (n. 38), p. 279.
    • Short Sketch , Issue.38 , pp. 279
    • Meyer, A.1
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    • Recent Trends in Psychiatry
    • Charles G. Wagner, "Recent Trends in Psychiatry," Amer. J. Insan., 1917, 74: 14.
    • (1917) Amer. J. Insan. , vol.74 , pp. 14
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    • note
    • Flexner's observations were cited in a letter from E. E. Southard to Thomas W. Salmon, 24 July 1919, Salmon Boxes in American Foundation for Mental Hygiene Papers, Archives of Psychiatry, New York Hospital-Cornell Medical Center, New York, N.Y. See also Salmon to Southard, 21 July 1919, ibid.
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    • New York: William Wood
    • George M. Beard, A Practical Treatise on Nervous Exhaustion (Neurasthenia): Its Symptoms, Nature, Sequences, Treatment (New York: William Wood, 1880); idem, American Nervousness: Its Causes and Consequences (New York: Putnam, 1881). See also Charles E. Rosenberg, "The Place of George M. Beard in Nineteenth-Century Psychiatry," Bull. Hist. Med., 1962, 36: 245-59; and F. G. Gosling, Before Freud: Neurasthenia and the American Medical Community, 1870-1910 (Urbana: University of Illinois Press, 1987).
    • (1880) A Practical Treatise on Nervous Exhaustion (Neurasthenia): Its Symptoms, Nature, Sequences, Treatment
    • Beard, G.M.1
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    • New York: Putnam
    • George M. Beard, A Practical Treatise on Nervous Exhaustion (Neurasthenia): Its Symptoms, Nature, Sequences, Treatment (New York: William Wood, 1880); idem, American Nervousness: Its Causes and Consequences (New York: Putnam, 1881). See also Charles E. Rosenberg, "The Place of George M. Beard in Nineteenth-Century Psychiatry," Bull. Hist. Med., 1962, 36: 245-59; and F. G. Gosling, Before Freud: Neurasthenia and the American Medical Community, 1870-1910 (Urbana: University of Illinois Press, 1987).
    • (1881) American Nervousness: Its Causes and Consequences
    • Beard, G.M.1
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    • The Place of George M. Beard in Nineteenth-Century Psychiatry
    • George M. Beard, A Practical Treatise on Nervous Exhaustion (Neurasthenia): Its Symptoms, Nature, Sequences, Treatment (New York: William Wood, 1880); idem, American Nervousness: Its Causes and Consequences (New York: Putnam, 1881). See also Charles E. Rosenberg, "The Place of George M. Beard in Nineteenth-Century Psychiatry," Bull. Hist. Med., 1962, 36: 245-59; and F. G. Gosling, Before Freud: Neurasthenia and the American Medical Community, 1870-1910 (Urbana: University of Illinois Press, 1987).
    • (1962) Bull. Hist. Med. , vol.36 , pp. 245-259
    • Rosenberg, C.E.1
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    • Urbana: University of Illinois Press
    • George M. Beard, A Practical Treatise on Nervous Exhaustion (Neurasthenia): Its Symptoms, Nature, Sequences, Treatment (New York: William Wood, 1880); idem, American Nervousness: Its Causes and Consequences (New York: Putnam, 1881). See also Charles E. Rosenberg, "The Place of George M. Beard in Nineteenth-Century Psychiatry," Bull. Hist. Med., 1962, 36: 245-59; and F. G. Gosling, Before Freud: Neurasthenia and the American Medical Community, 1870-1910 (Urbana: University of Illinois Press, 1987).
    • (1987) Before Freud: Neurasthenia and the American Medical Community, 1870-1910
    • Gosling, F.G.1
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    • New Brunswick, N.J.: Rutgers University Press
    • The literature on eugenics is large, and includes Mark H. Haller, Eugenics: Hereditarian Attitudes in American Thought (New Brunswick, N.J.: Rutgers University Press, 1963); Donald K. Pickens, Eugenics and the Progressives (Nashville: Vanderbilt Press, 1968); Daniel J. Kevles, In the Name of Eugenics: Genetics and the Uses of Human Heredity (New York: Knoft, 1985); Philip P. Reilly, The Surgical Solution: A History of Involuntary Sterilization in the United States (Baltimore: Johns Hopkins University Press, 1991); Edward J. Larson, Sex, Race, and Science: Eugenics in the Deep South (Baltimore: Johns Hopkins University Press, 1995); and Dobiggin, Keeping America Sane (n. 36).
    • (1963) Eugenics: Hereditarian Attitudes in American Thought
    • Haller, M.H.1
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    • Nashville: Vanderbilt Press
    • The literature on eugenics is large, and includes Mark H. Haller, Eugenics: Hereditarian Attitudes in American Thought (New Brunswick, N.J.: Rutgers University Press, 1963); Donald K. Pickens, Eugenics and the Progressives (Nashville: Vanderbilt Press, 1968); Daniel J. Kevles, In the Name of Eugenics: Genetics and the Uses of Human Heredity (New York: Knoft, 1985); Philip P. Reilly, The Surgical Solution: A History of Involuntary Sterilization in the United States (Baltimore: Johns Hopkins University Press, 1991); Edward J. Larson, Sex, Race, and Science: Eugenics in the Deep South (Baltimore: Johns Hopkins University Press, 1995); and Dobiggin, Keeping America Sane (n. 36).
    • (1968) Eugenics and the Progressives
    • Pickens, D.K.1
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    • New York: Knoft
    • The literature on eugenics is large, and includes Mark H. Haller, Eugenics: Hereditarian Attitudes in American Thought (New Brunswick, N.J.: Rutgers University Press, 1963); Donald K. Pickens, Eugenics and the Progressives (Nashville: Vanderbilt Press, 1968); Daniel J. Kevles, In the Name of Eugenics: Genetics and the Uses of Human Heredity (New York: Knoft, 1985); Philip P. Reilly, The Surgical Solution: A History of Involuntary Sterilization in the United States (Baltimore: Johns Hopkins University Press, 1991); Edward J. Larson, Sex, Race, and Science: Eugenics in the Deep South (Baltimore: Johns Hopkins University Press, 1995); and Dobiggin, Keeping America Sane (n. 36).
    • (1985) In the Name of Eugenics: Genetics and the Uses of Human Heredity
    • Kevles, D.J.1
  • 85
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    • Baltimore: Johns Hopkins University Press
    • The literature on eugenics is large, and includes Mark H. Haller, Eugenics: Hereditarian Attitudes in American Thought (New Brunswick, N.J.: Rutgers University Press, 1963); Donald K. Pickens, Eugenics and the Progressives (Nashville: Vanderbilt Press, 1968); Daniel J. Kevles, In the Name of Eugenics: Genetics and the Uses of Human Heredity (New York: Knoft, 1985); Philip P. Reilly, The Surgical Solution: A History of Involuntary Sterilization in the United States (Baltimore: Johns Hopkins University Press, 1991); Edward J. Larson, Sex, Race, and Science: Eugenics in the Deep South (Baltimore: Johns Hopkins University Press, 1995); and Dobiggin, Keeping America Sane (n. 36).
    • (1991) The Surgical Solution: A History of Involuntary Sterilization in the United States
    • Reilly, P.P.1
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    • Baltimore: Johns Hopkins University Press
    • The literature on eugenics is large, and includes Mark H. Haller, Eugenics: Hereditarian Attitudes in American Thought (New Brunswick, N.J.: Rutgers University Press, 1963); Donald K. Pickens, Eugenics and the Progressives (Nashville: Vanderbilt Press, 1968); Daniel J. Kevles, In the Name of Eugenics: Genetics and the Uses of Human Heredity (New York: Knoft, 1985); Philip P. Reilly, The Surgical Solution: A History of Involuntary Sterilization in the United States (Baltimore: Johns Hopkins University Press, 1991); Edward J. Larson, Sex, Race, and Science: Eugenics in the Deep South (Baltimore: Johns Hopkins University Press, 1995); and Dobiggin, Keeping America Sane (n. 36).
    • (1995) Sex, Race, and Science: Eugenics in the Deep South
    • Larson, E.J.1
  • 87
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    • The literature on eugenics is large, and includes Mark H. Haller, Eugenics: Hereditarian Attitudes in American Thought (New Brunswick, N.J.: Rutgers University Press, 1963); Donald K. Pickens, Eugenics and the Progressives (Nashville: Vanderbilt Press, 1968); Daniel J. Kevles, In the Name of Eugenics: Genetics and the Uses of Human Heredity (New York: Knoft, 1985); Philip P. Reilly, The Surgical Solution: A History of Involuntary Sterilization in the United States (Baltimore: Johns Hopkins University Press, 1991); Edward J. Larson, Sex, Race, and Science: Eugenics in the Deep South (Baltimore: Johns Hopkins University Press, 1995); and Dobiggin, Keeping America Sane (n. 36).
    • Keeping America Sane , Issue.36
    • Dobiggin1
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    • Presidential Address
    • G. Alder Blumer, "Presidential Address," Amer. J. Insan., 1903, 60: 1-18.
    • (1903) Amer. J. Insan. , vol.60 , pp. 1-18
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    • New York: McGraw-Hill
    • National Research Council, Committee on Psychiatric Investigations, The Problem of Mental Disorder (New York: McGraw-Hill, 1934).
    • (1934) The Problem of Mental Disorder
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    • New York: Macmillan
    • Committee of the American Neurological Association for the Investigation of Eugenical Sterilization (Abraham Myerson et al.), Eugenical Sterilization: A Reorientation of the Problem (New York: Macmillan, 1936). See also Abraham Myerson, "A Critique of Proposed 'Ideal' Sterilization Legislation," Arch. Neurol. Psychiatry, 1935, 33: 453-66.
    • (1936) Eugenical Sterilization: A Reorientation of the Problem
    • Myerson, A.1
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    • A Critique of Proposed 'Ideal' Sterilization Legislation
    • Committee of the American Neurological Association for the Investigation of Eugenical Sterilization (Abraham Myerson et al.), Eugenical Sterilization: A Reorientation of the Problem (New York: Macmillan, 1936). See also Abraham Myerson, "A Critique of Proposed 'Ideal' Sterilization Legislation," Arch. Neurol. Psychiatry, 1935, 33: 453-66.
    • (1935) Arch. Neurol. Psychiatry , vol.33 , pp. 453-466
    • Myerson, A.1
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    • The Etiology of So-Called Schizophrenic Psychoses with Special Reference to Their Occurrence in Twins
    • A list of these studies can be found in Aaron J. Rosanoff, Leva M. Handy, Isabel Rosanoff Plesset, and Sandye Brush, "The Etiology of So-Called Schizophrenic Psychoses with Special Reference to Their Occurrence in Twins," Amer. J. Psychiatry, 1934, 91: 247-86.
    • (1934) Amer. J. Psychiatry , vol.91 , pp. 247-286
    • Rosanoff, A.J.1    Handy, L.M.2    Plesset, I.R.3    Brush, S.4
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    • The Etiology of Manic-Depressive Syndromes with Special Reference to Their Occurrence in Twins
    • Aaron J. Rosanoff, Leva M. Handy, and Isabel Rosanoff Plesset, "The Etiology of Manic-Depressive Syndromes with Special Reference to Their Occurrence in Twins," Amer. J. Psychiatry, 1935, 91: 725-62.
    • (1935) Amer. J. Psychiatry , vol.91 , pp. 725-762
    • Rosanoff, A.J.1    Handy, L.M.2    Plesset, I.R.3
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    • New York: Augustin
    • Franz J. Kallmann, The Genetics of Schizophrenia: A Study of Heredity and Reproduction in the Families of 1,087 Schizophrenics (New York: Augustin, 1938); idem, Heredity in Health and Mental Disorder: Principles of Psychiatric Genetics in the Light of Comparative Twin Studies (New York: Norton, 1953). A convenient summary of Kallmann's findings, along with the statistical results of comparable studies, can be found in David Rosenthal, Genetic Theory and Abnormal Behavior (New York: McGraw-Hill, 1970). In The Genetics of Schizophrenia, Kallmann indicated that he was not averse to using the authority of the state to enforce eugenic prophylactic measures in certain cases.
    • (1938) The Genetics of Schizophrenia: A Study of Heredity and Reproduction in the Families of 1,087 Schizophrenics
    • Kallmann, F.J.1
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    • New York: Norton
    • Franz J. Kallmann, The Genetics of Schizophrenia: A Study of Heredity and Reproduction in the Families of 1,087 Schizophrenics (New York: Augustin, 1938); idem, Heredity in Health and Mental Disorder: Principles of Psychiatric Genetics in the Light of Comparative Twin Studies (New York: Norton, 1953). A convenient summary of Kallmann's findings, along with the statistical results of comparable studies, can be found in David Rosenthal, Genetic Theory and Abnormal Behavior (New York: McGraw-Hill, 1970). In The Genetics of Schizophrenia, Kallmann indicated that he was not averse to using the authority of the state to enforce eugenic prophylactic measures in certain cases.
    • (1953) Heredity in Health and Mental Disorder: Principles of Psychiatric Genetics in the Light of Comparative Twin Studies
    • Kallmann, F.J.1
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    • New York: McGraw-Hill
    • Franz J. Kallmann, The Genetics of Schizophrenia: A Study of Heredity and Reproduction in the Families of 1,087 Schizophrenics (New York: Augustin, 1938); idem, Heredity in Health and Mental Disorder: Principles of Psychiatric Genetics in the Light of Comparative Twin Studies (New York: Norton, 1953). A convenient summary of Kallmann's findings, along with the statistical results of comparable studies, can be found in David Rosenthal, Genetic Theory and Abnormal Behavior (New York: McGraw-Hill, 1970). In The Genetics of Schizophrenia, Kallmann indicated that he was not averse to using the authority of the state to enforce eugenic prophylactic measures in certain cases.
    • (1970) Genetic Theory and Abnormal Behavior
    • Rosenthal, D.1
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    • Franz J. Kallmann, The Genetics of Schizophrenia: A Study of Heredity and Reproduction in the Families of 1,087 Schizophrenics (New York: Augustin, 1938); idem, Heredity in Health and Mental Disorder: Principles of Psychiatric Genetics in the Light of Comparative Twin Studies (New York: Norton, 1953). A convenient summary of Kallmann's findings, along with the statistical results of comparable studies, can be found in David Rosenthal, Genetic Theory and Abnormal Behavior (New York: McGraw-Hill, 1970). In The Genetics of Schizophrenia, Kallmann indicated that he was not averse to using the authority of the state to enforce eugenic prophylactic measures in certain cases.
    • The Genetics of Schizophrenia
    • Kallmann1
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    • Utica, N.Y.: State Hospitals Press
    • Horatio M. Pollock, Mental Disease and Social Welfare (Utica, N.Y.: State Hospitals Press, 1941), pp. 117-33, quotation on p. 130. See also Horatio M. Pollock, Benjamin Malzberg, and Raymond G. Fuller, Hereditary and Environmental Factors in the Causation of Manic-Depressive Psychoses and Dementia Praecox (Utica, N.Y.: State Hospitals Press, 1939).
    • (1941) Mental Disease and Social Welfare , pp. 117-133
    • Pollock, H.M.1
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    • Preventive Psychiatry: An Epidemiologic Approach
    • Examples of this kind of thinking include John W. Appel and Gilbert M. Beebe, "Preventive Psychiatry: An Epidemiologic Approach," JAMA, 1946, 131: 1469-75; John W. Appel, "Incidence of Neuropsychiatric Disorders in the United States Army in World War II," Amer. J Psychiatry, 1945, 102: 433-36; Roy R. Grinker and John P. Spiegel, Men Under Stress (Philadelphia: Blakiston, 1945), pp. 427-60; Thomas A. C. Rennie and Luther E. Woodward, Mental Health in Modern Society (New York: Commonwealth Fund, 1948); and William C. Menninger, Psychiatry in a Troubled World: Yesterday's War and Today's Challenge (New York: Macmillan, 1948). A detailed history of post-World War II developments can be found in Gerald N. Grob, From Asylum to Community: Mental Health Policy in Modern America (Princeton: Princeton University Press, 1991).
    • (1946) JAMA , vol.131 , pp. 1469-1475
    • Appel, J.W.1    Beebe, G.M.2
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    • Incidence of Neuropsychiatric Disorders in the United States Army in World War II
    • Examples of this kind of thinking include John W. Appel and Gilbert M. Beebe, "Preventive Psychiatry: An Epidemiologic Approach," JAMA, 1946, 131: 1469-75; John W. Appel, "Incidence of Neuropsychiatric Disorders in the United States Army in World War II," Amer. J Psychiatry, 1945, 102: 433-36; Roy R. Grinker and John P. Spiegel, Men Under Stress (Philadelphia: Blakiston, 1945), pp. 427-60; Thomas A. C. Rennie and Luther E. Woodward, Mental Health in Modern Society (New York: Commonwealth Fund, 1948); and William C. Menninger, Psychiatry in a Troubled World: Yesterday's War and Today's Challenge (New York: Macmillan, 1948). A detailed history of post-World War II developments can be found in Gerald N. Grob, From Asylum to Community: Mental Health Policy in Modern America (Princeton: Princeton University Press, 1991).
    • (1945) Amer. J Psychiatry , vol.102 , pp. 433-436
    • Appel, J.W.1
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    • Philadelphia: Blakiston
    • Examples of this kind of thinking include John W. Appel and Gilbert M. Beebe, "Preventive Psychiatry: An Epidemiologic Approach," JAMA, 1946, 131: 1469-75; John W. Appel, "Incidence of Neuropsychiatric Disorders in the United States Army in World War II," Amer. J Psychiatry, 1945, 102: 433-36; Roy R. Grinker and John P. Spiegel, Men Under Stress (Philadelphia: Blakiston, 1945), pp. 427-60; Thomas A. C. Rennie and Luther E. Woodward, Mental Health in Modern Society (New York: Commonwealth Fund, 1948); and William C. Menninger, Psychiatry in a Troubled World: Yesterday's War and Today's Challenge (New York: Macmillan, 1948). A detailed history of post-World War II developments can be found in Gerald N. Grob, From Asylum to Community: Mental Health Policy in Modern America (Princeton: Princeton University Press, 1991).
    • (1945) Men under Stress , pp. 427-460
    • Grinker, R.R.1    Spiegel, J.P.2
  • 114
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    • New York: Commonwealth Fund
    • Examples of this kind of thinking include John W. Appel and Gilbert M. Beebe, "Preventive Psychiatry: An Epidemiologic Approach," JAMA, 1946, 131: 1469-75; John W. Appel, "Incidence of Neuropsychiatric Disorders in the United States Army in World War II," Amer. J Psychiatry, 1945, 102: 433-36; Roy R. Grinker and John P. Spiegel, Men Under Stress (Philadelphia: Blakiston, 1945), pp. 427-60; Thomas A. C. Rennie and Luther E. Woodward, Mental Health in Modern Society (New York: Commonwealth Fund, 1948); and William C. Menninger, Psychiatry in a Troubled World: Yesterday's War and Today's Challenge (New York: Macmillan, 1948). A detailed history of post-World War II developments can be found in Gerald N. Grob, From Asylum to Community: Mental Health Policy in Modern America (Princeton: Princeton University Press, 1991).
    • (1948) Mental Health in Modern Society
    • Rennie, T.A.C.1    Woodward, L.E.2
  • 115
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    • New York: Macmillan
    • Examples of this kind of thinking include John W. Appel and Gilbert M. Beebe, "Preventive Psychiatry: An Epidemiologic Approach," JAMA, 1946, 131: 1469-75; John W. Appel, "Incidence of Neuropsychiatric Disorders in the United States Army in World War II," Amer. J Psychiatry, 1945, 102: 433-36; Roy R. Grinker and John P. Spiegel, Men Under Stress (Philadelphia: Blakiston, 1945), pp. 427-60; Thomas A. C. Rennie and Luther E. Woodward, Mental Health in Modern Society (New York: Commonwealth Fund, 1948); and William C. Menninger, Psychiatry in a Troubled World: Yesterday's War and Today's Challenge (New York: Macmillan, 1948). A detailed history of post-World War II developments can be found in Gerald N. Grob, From Asylum to Community: Mental Health Policy in Modern America (Princeton: Princeton University Press, 1991).
    • (1948) Psychiatry in a Troubled World: Yesterday's War and Today's Challenge
    • Menninger, W.C.1
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    • Princeton: Princeton University Press
    • Examples of this kind of thinking include John W. Appel and Gilbert M. Beebe, "Preventive Psychiatry: An Epidemiologic Approach," JAMA, 1946, 131: 1469-75; John W. Appel, "Incidence of Neuropsychiatric Disorders in the United States Army in World War II," Amer. J Psychiatry, 1945, 102: 433-36; Roy R. Grinker and John P. Spiegel, Men Under Stress (Philadelphia: Blakiston, 1945), pp. 427-60; Thomas A. C. Rennie and Luther E. Woodward, Mental Health in Modern Society (New York: Commonwealth Fund, 1948); and William C. Menninger, Psychiatry in a Troubled World: Yesterday's War and Today's Challenge (New York: Macmillan, 1948). A detailed history of post-World War II developments can be found in Gerald N. Grob, From Asylum to Community: Mental Health Policy in Modern America (Princeton: Princeton University Press, 1991).
    • (1991) From Asylum to Community: Mental Health Policy in Modern America
    • Grob, G.N.1
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    • New York: Knopf
    • See especially Lawrence Friedman, Menninger: The Family and the Clinic (New York: Knopf, 1990); and Nathan G. Hale, Jr., The Rise and Crisis of Psychoanalysis in the United States: Freud and the Americans, 1917-1985 (New York: Oxford University Press, 1995).
    • (1990) Menninger: The Family and the Clinic
    • Friedman, L.1
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    • Mental Hygiene and Socio-Environmental Factors
    • Robert H. Felix and R. V. Bowers, "Mental Hygiene and Socio-Environmental Factors," Milbank Memorial Fund Quart., 1948, 26: 125-47, quotation on p. 125.
    • (1948) Milbank Memorial Fund Quart. , vol.26 , pp. 125-147
    • Felix, R.H.1    Bowers, R.V.2
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    • presentation at St. Elizabeths Hospital, Washington, D.C., 21 April 1945, Felix Papers, National Library of Medicine, Bethesda, Md.
    • Robert H. Felix, "Mental Public Health: A Blueprint," presentation at St. Elizabeths Hospital, Washington, D.C., 21 April 1945, Felix Papers, National Library of Medicine, Bethesda, Md. See also Paul V. Lemkau, "The Future Organization of Psychiatric Care," Psychiatric Quart., 1951, 25: 201-12.
    • Mental Public Health: A Blueprint
    • Felix, R.H.1
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    • The Future Organization of Psychiatric Care
    • Robert H. Felix, "Mental Public Health: A Blueprint," presentation at St. Elizabeths Hospital, Washington, D.C., 21 April 1945, Felix Papers, National Library of Medicine, Bethesda, Md. See also Paul V. Lemkau, "The Future Organization of Psychiatric Care," Psychiatric Quart., 1951, 25: 201-12.
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    • In suggesting that the proclaimed potential benefits of the Human Genome Project are unrealistic, I do not wish to imply that the pursuit of genetic knowledge is futile. Unfortunately, there is a prevailing belief that genetic findings will be both simple and deterministic. The most sophisticated work in this field, by contrast, suggests the very opposite. Single major gene diseases are the exception rather than the rule. More importantly, there is no simple correspondence between genotype and phenotype; multiple genes interact with each other as well as with the environment. The same genotype can give rise to a different phenotype; conversely, different genotypes can produce the same phenotype. In effect, the findings of modern genetics can only be stated in terms of probabilities, which hardly differs from the older concept of predisposition or diathesis.
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