IGF-I levels in different conditions of low somatotrope secretion in adulthood: Obesity in comparison with GH deficiency

Panminerva Medica

Volumn 40, Issue 2, 1998, Pages 98-102

  Maccario, M ^a   Grottoli, S ^a   Aimaretti, G ^a   Gianotti, L ^a   Endrio Oleandri, S ^a   Procopio, M ^a   Savio, P ^a   Tassone, F ^a   Ramunni, J ^a   Camanni, F ^a   Ghigo, E ^a,b  

^a UNIVERSITY OF TURIN   (Italy)

^b MOLINETTE HOSPITAL   (Italy)

Author keywords

Age; Body mass; Insuline like growth factor I; Obesity; Somatotropin deficiency

Indexed keywords

HUMAN GROWTH HORMONE; SOMATOMEDIN C;

ADENOHYPOPHYSIS; ADOLESCENT; ADULT; AGED; ARTICLE; CLINICAL TRIAL; COMPARATIVE STUDY; CONTROLLED STUDY; FEMALE; HUMAN; MALE; METABOLISM; MIDDLE AGED; OBESITY; PATHOPHYSIOLOGY; SECRETION;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; FEMALE; HUMAN GROWTH HORMONE; HUMANS; INSULIN-LIKE GROWTH FACTOR I; MALE; MIDDLE AGED; OBESITY; PITUITARY GLAND, ANTERIOR;

EID: 0032084641     PISSN: 00310808     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (28)

1. Glass AR. Endocrine aspects of obesity. Med Clin North Am 1989;73:139-60.
2. Veldhuis JD, Iranmanesh A, Ho KKY, Waters MJ, Johnson ML, Lizarralde G. Dual defects in pulsatile growth hormone secretion and clearance subserve the hyposomatotropism of obesity in man. J Clin Endocrinol Metab 1991;72:51-9.
3. Kelijman M, Frohman LA. Enhanced growth hormone responsiveness to GH-releasing hormone after dietary manipulation in obese and nonobese subjects. J Clin Endocrinol Metab 1988;66:489-94.
4. Tanaka K, Inoue S, Numata K, Okazaki H, Nakamura S, Takamura Y Very-low-calorie diet-induced weight reduction reverses impaired growth hormone secretion response to growth hormone-releasing hormone, arginine and L-dopa in obesity. Metabolism 1990;39:892-6.
5. Rassmussen MH, Juul A, Kjiems LL, Skakkebaek NE, Hilsted J. Lack of stimulation of 24-hour growth hormone release by hypocaloric diet in obesity. J Clin Endocrinol Metab 1995;80:796-801.
6. Berelowitz M, Finkelstein JA, Thominet JL, Ting NC, Nirh JL, Frohman LA. Impaired growth hormone secretion in spontaneous experimental obesity: a result of increased somatostatin (SRIF) tone. San Antonio: 64th Annual Meeting of Endocrine Society, TX, 1983:84 (abstract 16).
7. Taylor LM, Blackard WG. Effects of lipids on growth hormone synthesis by isolated pituitaries. Proc Soc Exp Biol Med 1971;73:765-70.
8. Renier G, Abribat T, Brazeau P, Deslauriers P, Gradeau P. Cellular mechanism of caprylic acid-induced growth hormone suppression. Metabolism 1990;39:1108-12.
9. Casabiel X, Pandiella A, Casanueva FF. Cis-unsaturated free fatty acids (FFA) block signal transduction at membrane level. J Endocrinol Invest 1989;12(Suppl 2):160
10. Gaufriez A, Golstein J, Lebrun P, Herchuelz A, Furlanetto R, Copinschi G. Relations between immunoreactive somatomedin C, insulin and T3 patterns during fasting in obese subjects. Clin Endocrinol 1984;20:65-70.
11. Phillips L, Unterman T. Somatomedin activity in disorders of nutrition and metabolism, Clin Endocrinol Metab 1984;13:145-89.
12. Van Vliet G, Bosson D, Rummens E, Robyn C, Wolter R. Evidence against growth hormone-releasing factor deficiency in children with idiopathic obesity. Acta Endocrinol 1986;(Suppl 279):403-10.
13. Loche S, Cappa M, Borrelli P et al. Reduced growth hormone response to growth hormone-releasing hormone in children with simple obesity: evidence for somatomedin-C mediated inhibition. Clin Endocrinol 1987;27:145-53.
14. Copeland KC, Underwood LE, Van Wyk JJ. Induction of immunoreactive somatomedin-C in human serum by growth hormone: dose response relationships and effect on chromatographic profiles. J Clin Endocrinol Metab 1980;50:690-7.
15. Casanueva FF, Burguera B, Muruais C, Dieguez C. Acute administration of corticoids: a new and peculiar stimulus of GH secretion in man. J Clin Endocrinol Metab 1990;70:234-7.
16. Thissen JP, Ketelslegers JM, Underwood LE. Nutritional regulation of the Insulin-like Growth Factors. Endocrine Reviews 1994;15(1):80-101.
17. Jones JI, Clemmons DR. Insulin-like growth factors and their binding proteins: biological actions. Endocrinol Rev 1995;16:3-34.
18. Corpas E, Harman SM, Blackman S. Human growth hormone and human aging. Endocrinol Rev 1993;14:20-39.
19. Ghigo E, Arvat E, Goffi S et al. Neural control of growth hormone secretion in aged humans. In: Muller EE, Cocchi D, Locatelli V, editors. Growth hormone and somatomedins during lifespan. Berlin: Springer Verlag, 1993:275-87.
20. Ghigo E, Aimaretti G, Gianotti L, Bellone J, Arvat E, Camanni F. New approach to the diagnosis of growth hormone deficiency in adults. Eur J Endocrinol 1996;134:352-6.
21. Kelijman M. Age-related alterations of the growth hormone/insulin-like-growth-factor I axis. J Am Geriatr Soc 1991;39:295-307.
22. Froesch ER, Guler HP, Schmid C, Bink K, Zapf J. Therapeutic potential of insulin-like growth factor I. Trends Endocrinol Metab 1990;1:254-60.
23. Dieguez C, Page MD, Scanlon MF. Growth hormone neuroregulation and its alterations in diseases states. Clin Endocrinol (Oxf) 1989;28:109-21.
24. Copeland KC, Colletti RB, Devlin JT, McAuliffe TL. The relationship between insulin-like growth factor I, adiposity, and aging. Metabolism 1990;39:584-7.
25. Rassmussen MH, Frystyk J, Andersen T, Breum L, Christiansen JS. Hilsted J. The impact of obesity, fat distribution and energy restriction on insulin-like growth factor I (IGF-I), IGF-binding protein-3, insulin and growth hormone. Metabolism 1994;43:315-9.
26. Frystyk J, Vestibo E, Skjaerbaek C, Mogensen CE, Qrskov H. Free Insulin-like Growth Factors in human obesity. Metabolism 1995;44(10 Suppl 4):37-44.
27. De Boer H, Blok GJ, Poo-Snijders C, Van der Veen EA. Diagnosis of growth hormone deficiency in adults. Lancet 1994;343(11): 1645-6.
28. Bates AS, Evans AJ, Jones P, Clayton RN. Assessment of GH status in adults with GH deficiency using serum growth hormone, serum insulin-like growth factor I and urinary growth hormone excretion. Clin Endocrinol 1995;42:425-30.