A computer-based expert system designs and analyzes a 2((k-p)) fractional factorial design for the formulation optimization of novel multicomponent liposomes

Journal of Pharmaceutical and Biomedical Analysis

Volumn 17, Issue 1, 1998, Pages 133-140

  Loukas, Yannis L ^a,b  

^a UNIVERSITY OF LONDON   (United Kingdom)

^b NONE   (Greece)

Author keywords

Analytical techniques; Experimental design; Fractional factorial design; Optimization; Sodium ascorbate; Vesicular systems

Indexed keywords

ALPHA CYCLODEXTRIN; ASCORBIC ACID; LIPOSOME; OXYBENZONE; SULISOBENZONE;

ARTICLE; DRUG FORMULATION; DRUG STABILITY; EXPERT SYSTEM; FACTORIAL ANALYSIS; LIPID BILAYER; PHOTOOXIDATION; PRIORITY JOURNAL; SPECTROPHOTOMETRY;

CHEMISTRY, PHARMACEUTICAL; DRUG CARRIERS; DRUG STABILITY; EXPERT SYSTEMS; LIPOSOMES; OXIDATION-REDUCTION; PHOTOCHEMISTRY;

EID: 0032080684     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0731-7085(97)00173-8     Document Type: Article

References (13)

1. G. Gregoriadis, Y.L. Loukas, PCT international application no: GB95/01258 (1995).
2. Loukas Y.L., Jayasekera P., Gregoriadis G. J. Phys. Chem. 99:1995;11035-11040.
3. Loukas Y.L., Jayasekera P., Gregoriadis G. Int. J. Pharm. 117:1995;85-94.
4. Ho A., Puri K., Sugden J.K. Int. J. Pharm. 107:1994;199-207.
5. D. Montgomery, Design and Analysis of Experiments, Wiley, Chichester, 1991.
6. G.E.P. Box, W.G. Hunter, S.J. Hunter, Statistics for Experimenters: An Introduction to Design, Data Analysis, and Model Building, Wiley, New York, 1978.
7. Loukas Y.L. Pharm. Sci. 1:1995;509-512.
8. Loukas Y.L. Analyst. 121:1996;279-284.
9. G.E.P. Box, N.R. Draper, Empirical Model-Building and Response Surfaces, Wiley, New York, 1987.
10. S.N. Deming, S.L. Morgan, Experimental design: A Chemometric Approach, Elsevier Science, Amsterdam, The Netherlands, 1993.
11. Statistica/w, version 5.0, Statsoft UK, Bigglesware, Bedfordshire, SG18 8AX, UK.
12. Loukas Y.L., Vraka V., Gregoriadis G. Pharm. Sci. 2:1996;523-527.
13. T.P. Ryan, Statistical Methods for Quality Improvement, Wiley, New York, 1989.