Serotonergic ergoline derivatives

Bioorganic and Medicinal Chemistry Letters

Volumn 8, Issue 9, 1998, Pages 1117-1122

  Mantegani, Sergio ^a   Brambilla, Enzo ^a   Caccia, Carla ^a   Damiani, Gabriele ^a   Fornaretto, Maria Gioia ^a   McArthur, Robert A ^a   Varasi, Mario ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DOPAMINE RECEPTOR; ERGOLINE DERIVATIVE; RECEPTOR SUBTYPE; SEROTONIN RECEPTOR;

ARTICLE; BINDING AFFINITY; DOPAMINERGIC TRANSMISSION; DRUG DESIGN; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG SYNTHESIS; RECEPTOR INTRINSIC ACTIVITY; SEROTONINERGIC SYSTEM; STRUCTURE ACTIVITY RELATION;

ANIMALS; BINDING, COMPETITIVE; DRUG DESIGN; ERGOLINES; HIPPOCAMPUS; INDICATORS AND REAGENTS; PREFRONTAL CORTEX; RADIOLIGAND ASSAY; RATS; RECEPTORS, ADRENERGIC, ALPHA; RECEPTORS, DOPAMINE; RECEPTORS, SEROTONIN; RECEPTORS, SEROTONIN, 5-HT1; SEROTONIN AGONISTS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0032080356     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(98)00166-8     Document Type: Article

References (15)

1. 1. Zifa, E.; Fillion, G. Pharmacol. Rev. 1992, 44(3), 401.
2. 2. Blier, P.; Montigny, C. Trends Pharmacol. Sci. 1994, 15, 220.
3. 3. Humphrey, P. P.; Hartig, P.; Hoyer, D. Trends Pharmacol Sci. 1993, 14, 233-236.
4. 4. Herndon, J. L.; Abd Ismaiel; Ingher, S. P.; Teitler, M.; Glennon, R. J. Med. Chem. 1992, 35, 4903.
5. 5. Ninomiya, A.; Kiguchi, T. The Ergot Alkaloids in The Alkaloids: Chemistry and Pharmacology, Brossi, A. Eds. Academic Press Inc., San Diego, 1990, vol. 38, pp. 1-156.
6. 6. Tedesco, J. L.; Seeman, P.; Mc Dermed, J D. Mol. Pharmacol. 1979, 16, 369.
7. 7. Nilsson, J G L.; Svensson, K.; Hjorth, S.; Carlsson, A. J. Med. Chem. 1985, 28, 215.
8. 8. Mantegani, S.; Brambilla, E.; Caccia, C; McArthur, R.; M., Varasi. Eur. J. Med. Chem. 1997, 32, 795-804.
9. 9. Mantegani, S., personal comunication (Different percentage and distribution of 13- and 14-tertbutyl derivatives were observed when 2-bromo- and 2-chlorodihydrolysergic acid methyl ester were submitted to the reaction's condition herein reported)
10. 10. SIMES Società Italiana Medicinali e Sintetici 1977 Swiss Patent 8255/77.
11. +); 180 (10); 176 (10); 154 (8); 57 (13). mp 191-193 °C.
12. 12. Saigo, K.; Usui, M.; Kikushi, K.; Shimada, E.; Mukaiyama, T. Chem. Lett. 1977, 1863.
13. 13. Brambilla, E.; Di Salle, E.; Mantegani, S.; Temperilli, A. Eur. J. Med. Chem. 1989, 24, 421.
14. 14. Hughes, D. L. The Mitsunobu Reaction. In Organic Reactions; Paquette, Leo A. Ed. John Wiley & Sons, New York, 1992, vol. 42, 335-656.
15. 15. Fargin, A.; Raymond, J. R.; Regan, J. W.; Cotecchia, S.; Lefkowitz, R. J.; Caron, M. G. J. Biol. Chem. 1989, 264, 14848-14852.