Ligand-induced domain movement in an antibody Fab: Molecular dynamics studies confirm the unique domain movement observed experimentally for Fab NC6.8 upon complexation and reveal its segmental flexibility

Journal of Molecular Biology

Volumn 278, Issue 2, 1998, Pages 301-306

  Sotriffer, Christoph A ^a   Liedl, Klaus R ^a   Linthicum, D Scott ^b   Rode, Bernd M ^a   Varga, Janos M ^a  

^a UNIVERSITY OF INNSBRUCK   (Austria)

^b TEXAS A AND M UNIVERSITY   (United States)

Author keywords

Anti sweetener antibody NC6.8; Antibody hapten interactions; Conformational changes; Fab segmental flexibility; MD simulation

Indexed keywords

GUANIDINE; HAPTEN; HAPTEN ANTIBODY; IMMUNOGLOBULIN F(AB) FRAGMENT; LIGAND;

BINDING SITE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; LIGAND BINDING; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN QUATERNARY STRUCTURE; REVIEW; X RAY CRYSTALLOGRAPHY;

EID: 0032080281     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.1998.1684     Document Type: Article

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