Increased axon growth through astrocyte cell lines transfected with urokinase

GLIA

Volumn 23, Issue 1, 1998, Pages 24-34

  Muir, E ^a   Du, J S ^a   Fok Seang, J ^a,b   Smith Thomas, L C ^a,b   Housden, E S ^a,b   Rogers, J ^a   Fawcett, J W ^a,b,c  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c Department of Physiology ^*  (United Kingdom)

Author keywords

Astrocyte; Axon growth; Urokinase plasminogen activator

Indexed keywords

RECOMBINANT PROTEIN; UROKINASE;

ANIMAL; ARTICLE; ASTROCYTE; BIOSYNTHESIS; CELL LINE; CULTURE MEDIUM; CYTOLOGY; EXTRACELLULAR MATRIX; GENETIC TRANSFECTION; MOUSE; NERVE CELL; NERVE FIBER; NERVE REGENERATION; PHYSIOLOGY; SPINAL GANGLION; ULTRASTRUCTURE;

ANIMALS; ASTROCYTES; AXONS; CELL LINE; CULTURE MEDIA, SERUM-FREE; EXTRACELLULAR MATRIX; GANGLIA, SPINAL; MICE; NERVE REGENERATION; NEURONS; RECOMBINANT PROTEINS; TRANSFECTION; URINARY PLASMINOGEN ACTIVATOR;

EID: 0032080074     PISSN: 08941491     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-1136(199805)23:1<24::AID-GLIA3>3.0.CO;2-4     Document Type: Article

References (78)

1. Amberger, V.R., Paganetti, P.A., Seulberger, H., Eldering, J.A., and Schwab, M.E. (1994) Characterization of a membrane-bound metalloendoprotease of rat C6 glioblastoma cells. Cancer Res., 54:4017-4025.
2. Axelrod, J.H., Reich, R., and Miskin, R. (1989) Expression of human recombinant plasminogen activators enhances invasion and experimental metastasis of H-ras-transformed NIH 3T3 cells. Mol. Cell. Biol., 9:2133-2141.
3. Bauer, J., Gebicke-Haerter, P.-J., Ganter, U., Richter, I., and Gerok, W. (1988) Astrocytes synthesize and secrete a2-macroglobulin: Differences between the regulation of a2-macroglobulin synthesis in rat liver and brain. Adv. Exp. Med. Biol., 240:199-205.
4. Berry, M., Hall, S., Rees, L., Carlile, J., and Wyse, J.P.H. (1992) Regeneration of axons in the optic nerve of the adult Browman-Wyse (BW) mutant rat. J. Neurocytol., 21:426-448.
5. Bicknese, A.R., Sheppard, A.M., O'Leary, D.D.M., and Pearlman, A.L. (1994) Thalamocortical axons extend along a chondroitin sulfate proteoglycan-enriched pathway coincident with the neocortical subplate and distinct from the efferent path. J. Neurosci., 14:3500-3510.
6. Blasi, F. (1993) Urokinase and urokinase receptor: A paracrine/ autocrine system regulating cell migration and invasiveness. BioEssays, 15:105-111.
7. Bonavaud, S., Charriere-Bertrand, C., Rey, C., Leibovitch, M.P., Pedersen, N., Frisdal, E., Planus, E., Blasi, F., Gherardi, R., and BarlovatzMeimon, G. (1997) Evidence of a non-conventional role for the urokinase tripartite complex (upar/upa/pai-1) in myogenic cell fusion. J. Cell Sci., 110:1083-1089.
8. Bovolenta, P., Wandosell, F., and Nieto-Sampedro, M. (1993a) Characterization of a neurite outgrowth inhibitor expressed after CNS injury. Eur. J. Neurosci., 5:454-465.
9. Bovolenta, P., Wandosell, F., and Nieto-Sampedro, M. (1993b) Neurite outgrowth inhibitors associated with glial cells and glial cell lines. NeuroReport, 5:345-348.
10. Brady, S.T. (1991) Molecular motors in the nervous system. Neuron, 7:521-533.
11. Braunewell, K.H., Pesheva, P., McCarthy, J.B., Furcht, L.T., Schmitz, B., and Schachner, M. (1995) Functional involvement of sciatic nerve-derived versican and decorin-like molecules and other chondroitin sulfate proteoglycans in ecm-mediated cell-adhesion and neurite outgrowth. Eur. J. Neuro., 7:805-814.
12. Brecknell, J.E., and Fawcett, J.W. (1996) Axonal regeneration. Biol. Rev., 71:227-255.
13. Busso, N., Masur, S.K., Lazega, D., Waxman, S., and Ossowski, L. (1994) Induction of cell migration by pro-urokinase binding to its receptor: Possible mechanism for signal transduction in human epithelial cells. J. Cell Biol., 126:259-270.
14. Carlstedt, T. (1985) Regenerating axons form nerve terminals on astrocytes. Brain Res., 347:188-191.
15. Crowley, C.W., Cohen, R.L., Lucas, B.K., Liu, G., Shuman, M.A., and Levinson, A.D. (1993) Prevention of metastasis by inhibition of the urokinase receptor. Proc. Natl. Acad. Sci. USA, 90:5021-5025.
16. Dean, R.T., and Schnebli, H.P. (1989) Control of exogenous proteinases and their inhibitors at the macrophage cell surface. Biochim. Biophys. Acta., 992:174-180.
17. Deng, G., Curriden, S.A., Wang, S.J., Rosenberg, S., and Loskutoff, D.J. (1996) Is plasminogen activator inhibitor-1 the molecular switch that governs urokinase receptor-mediated cell adhesion and release? J. Cell Biol., 134:1563-1571.
18. Duffy, M.J., Reilly, D., O'Sullivan, C., O'Higgins, N., and Fennely, J.J. (1990) Urokinase plasminogen activator and prognosis in breast cancer. Lancet, 13:108-111.
19. Ellis, V., Pyke, C., Eriksen, J., Solberg, H., and Dano, K. (1992) The urokinase receptor: Involvement in cell surface proteolysis and cancer invasion. Ann. NY Acad. Sci., 667:13-31.
20. Estreicher, A., Mühlhauser, J., Carpentier, J.-L., Orci, L., and Vassalli, J.-D. (1990) The receptor for urokinase type plasminogen activator polarizes expression of the protease to the leading edge of migrating monocytes and promotes degradation of enzyme inhibitor complexes. J. Cell Biol., 111:783-792.
21. Fawcett, J.W., and Housden, E. (1990) The effects of protease inhibitors on axon growth through astrocytes. Development, 109:59-66.
22. Fawcett, J.W., Housden, E., Smith-Thomas, L., Meyer, R.L. (1989) The growth of axons in three dimensional astrocyte cultures. Dev. Biol., 135:449-458.
23. Fazioli, F., and Blasi, F. (1994) Urokinase-type plasminogen activator and its receptor: new targets for anti-metastatic therapy? Trends in Pharmacological Sciences, 15:25-29.
24. Fok-Seang, J., Smith-Thomas, L., Muir, E., Du, J., Housden, E., Johnson, A.R., Faissner, A., Geller, H.M., Keynes, R.J., Rogers, J.H., and Fawcett, J.W. (1995) An analysis of astrocytic cell lines with different abilities to promote axon growth. Brain Res., 689:207-223.
25. Gebicke-Haerter, P.J., Bauer, J., Brenner, A., and Gerok, W. (1987) Alpha 2-macroglobulin synthesis in an astrocyte subpopulation. J. Neurochem., 49:1139-1145.
26. Gloor, S., Odink, K., Guenther, J., Nick, H., and Monard, D. (1986) A glia-derived neurite promoting factor with protease inhibitory activity belongs to the protease nexins. Cell, 47:687-693.
27. Gold, L.I., Rostagno, A., Frangione, B., and Passalaris, T. (1992) Localization of the cleavage sites on fibronectin following digestion by urokinase. J. Cell. Biochem., 50:441-452.
28. Grumet, M., Milev, P., Sakurai, T., Karthikeyan, L., Bourdon, M., Margolis, R.K., and Margolis, R.U. (1994) Interactions with tenascin and differential effects on cell adhesion of neurocan and phosphacan, two major chondroitin sulfate proteoglycans of nervous tissue. J. Biol. Chem., 269:12142-12146.
29. Hall, S.M., Berry, M., and Wyse, J.P.H. (1992) Regrowth of PNS axons through grafts of the optic nerve of the Browman-Wyse (BW) mutant rat. J. Neurocytol., 21:402-412.
30. Heiss, M.M., Babic, R., Allgeyer, H., Greutzner, K.U., Jauch, K.W., Loehrs, U., and Schildberg, F.W. (1995) Tumour-associated proteolysis and prognosis: new functional risk factors in gastric cancer defined by the urokinase-type plasminogen activation system. J. Clin. Oncol., 13:2085-2093.
31. Higazi, A.A.-R., Cohen, R.L., Henkin, J., Kniss, D., Schwartz, B.S., and Cines, D.B. (1995) Enhancement of the enzymatic activity of single-chain urokinase plasminogen activator by soluble urokinase receptor. J. Biol. Chem., 270:17375-17380.
32. Kalderon, N., Ahonen, K., and Fedoroff, S. (1990) Developmental transition in plasticity properties of differentiating astrocytes: Age-related biochemical profile of plasminogen activators in astroglial cultures. Glia, 3:413-426.
33. Keski-Oja, J., Lohi, J., Tuutila, A., Tryggvason, K., and Vartio, T. (1992) Proteolytic processing of the 72,000 Da type IV collagenase by urokinase plasminogen activator. Exp. Cell Res., 202:471-476.
34. Landau, B.J., Kwaan, H.C., Verrusio, E.N., and Brem, S.S. (1994) Elevated levels of urokinase-type plasminogen activator and plasminogen activator inhibitor type-1 in malignant human brain tumors. Cancer Res., 54:1105-1108.
35. Leco, K.J., Khokha, R., Pavloff, N., Hawkes, S.P., and Edwards, D.R. (1994) Tissue inhibitor of metalloproteinases-3 (TIMP-3) is an extracellular matrix-associated protein with a distinctive pattern of expression in mouse cells and tissues. J. Biol. Chem., 269:9352-9360.
36. Librach, C.L., Werb, Z., Fitzgerald, M.L., Chiu, K., Corwin, N.M., Esteves, R.A., Grobelny, D., Galardy, R., Damsky, C.H., and Fisher, S.J. (1991) 92-kD Type IV collagenase mediates invasion of human cytotrophoblasts. J. Cell Biol., 113:437-449.
37. Librach, C.L., Feigenbaum, S.L., Bass, K.E., Cui, T., Verastas, N., Sadovsky, Y., Quigley, J.P., French, D.L., and Fisher, S.J. (1994) Interleukin-1b regulates human cytotrophoblast metalloproteinase activity and invasion in vitro. J. Biol. Chem., 269:17125-17131.
38. Manchanda, N., and Schwartz, B. (1991) Single chain urokinase: Augmentation of enzymatic activity upon binding to monocytes. J. Biol. Chem., 266:145800-145804.
39. McKeon, R.J., Schreiber, R.C., Rudge, J.S., and Silver, J. (1991) Reduction of neurite outgrowth in a model of glial scarring following CNS injury is correlated with the expression of inhibitory molecules on reactive astrocytes. J. Neurosci., 11:3398-3411.
40. McKeon, R.J., Höke, A., and Silver, J. (1995) Injury-induced proteoglycans inhibit the potential for laminin-mediated axon growth on astrocytic scars. Exp. Neurol., 136:32-43.
41. Mignatti, P., and Rifkin, D.B. (1993) Biology and biochemistry of proteinases in tumor invasion. Physiol. Rev., 73:161-195.
42. Mohanam, S., Sawaya, R., McCutcheon, I., Ali-Osman, F., Boyd, D., and Rao, J.S. (1993) Modulation of in vitro invasion of human glioblastoma cells by urokinase-type plasminogen activator receptor antibody. Cancer Res., 53:4143-4147.
43. Murphy, G., Reynolds, J.J., and Hembry, R.M. (1989) Metalloproteinases and cancer invasion and metastasis. Int. J. Cancer, 44:757-760.
44. Murphy, G., Atkinson, S., Ward, R., Gavrilovic, J., and Reynolds, J.J. (1992) The role of plasminogen activators in the regulation of connective tissue metalloproteinases. Ann. NY Acad. Sci., 667:1-12.
45. Murphy, P., and Hart, D.A. (1992) Modulation of plasminogen activator and plasminogen activator inhibitor expression in the human U373 glioblastoma/astrocytoma cell line by inflammatory mediators. Exp. Cell Res., 198:93-100.
46. Nakajima, K., Reddington, M., Kohsaka, S., and Kreutzberg, G.W. (1996) Induction of urokinase-type plasminogen activator in rat facial nucleus by axotomy of the facial nerve. J. Neurochem., 66:2500-2505.
47. Nordstrom, L.A., Lochner, J., Yeung, W., and Ciment, G. (1995) The metalloproteinase stromelysin-1 (transin) mediates pc12 cell-growth cone invasiveness through basal laminae. Molecular Cell. Neuros., 6:56-68.
48. Ossowski, L., Clunie, G., Masucci, M.-T., and Blasi, F. (1991) In vivo paracrine interaction between urokinase and its receptor: Effect on tumor cell invasion. J. Cell Biol., 115:1107-1112.
49. Ossowski, L., Russo-Payne, H., and Wilson, E.L. (1991b) Inhibition of urokinase-type plasminogen activator by antibodies: The effect on dissemination of a human tumor in the nude mouse. Cancer Res., 51:274-281.
50. Pindzola, R.R., Doller, C., and Silver, J. (1993) Putative inhibitory extracellular matrix molecules at the dorsal root entry zone of the spinal cord during development and after root and sciatic nerve lesions. Dev. Biol., 156:34-48.
51. Pittman, R.N., Ivins, J.K., and Buettner, H.M. (1989) Neuronal plasminogen activators: Cell surface binding sites and involvement in neurite outgrowth. J. Neurosci., 9:4269-4286.
52. Pittman, R.N., and DiBenedetto, A.J. (1995) PC12 cells overexpressing tissue plasminogen activator regenerate neuntes to a greater extent and migrate faster than control cells in complex extracellular matrix. J. Neurochem., 64:566-575.
53. 2+-dependent metalloproteinase activity. Dev. Neurosci., 11:41-51.
54. Poole, A.R., Alini, M., and Hollander, A.P. (1995) Cellular biology of cartilage degradation. In: Mechanisms and models in rheumatoid arthritis. B. Henderson, J.C.W. Edwards, E.R. Pettipher, eds. Academic Press, London, pp 163-204.
55. Quax, P.H., van Muijen, G.N., Weening-Verhoeff, E.J., Lund, L.R., Dano, K., Ruiter, D.J., and Verheijen, J.H. (1991) Metastatic behavior of human melanoma cell lines in nude mice correlates with urokinase-type plasminogen activator, its type-1 inhibitor, and urokinase-mediated matrix degradation. J. Cell Biol., 115:191-199.
56. Redwood, S.M., Liu, B.C.-S., Weiss, R.E., Hodge, D.E., and Droller, M.J. (1992) Abrogation of the invasion of human bladder tumor cells by using protease inhibitor(s). Cancer, 69:1212-1219.
57. Reier, P.J., and Houle, J.D. (1988) The glial scar: its bearing on axonal elongation and transplantation approaches to CNS repair. Adv. Neurol., 47:87-138.
58. Rijken, D.C., and Groeneveld, E. (1991) Substrate specificity of tissue-type and urokinase-type plasminogen activators. Biochem. Biophys. Res. Comm., 174:432-438.
59. Rogister, B., Leprince, P., Pettmann, B., Labourdette, G., Sensenbrenner, M., and Moonen, G. (1988) Brain basic fibroblast growth factor stimulates the release of plasminogen activators by newborn rat cultured astroglial cells. Neurosci. Lett., 91:231-326.
60. Rogister, B., Leprince, P., Delree, P., van Damme, J., Billiau, A., and Moonen, G. (1990) Enhanced release of plasminogen activator inhibitor(s) but not of plasminogen activators by cultured rat glial cells treated with interleukin-1. GLIA, 3:252-257.
61. Rosenberg, G.A., Dencoff, J.E., McGuire, P.G., Liotta, L.A., and Stetler-Stevenson, W.G. (1994) Injury-induced 92-kilodalton gelatinase and urokinase expression in rat brain. Lab. Invest., 71:417-422.
62. Rosenblatt, D.E., Cotman, C.W., Nieto Sampedro, M., Rowe, J.W., and Knauer, D.J. (1987) Identification of a protease inhibitor produced by astrocytes that is structurally and functionally homologous to human protease nexin-I. Brain Res., 415:40-48.
63. Sallés, F.J., Schechter, N., and Strickland, S. (1990) A plasminogen activator is induced during goldfish optic nerve regeneration. EMBO J., 9:2471-2477.
64. Sappino, A.-P., Huarte, J., Belin, D., and Vassalli, J.-D. (1989) Plasminogen activators in tissue remodeling and invasion: mRNA localization in mouse ovaries and implanting embryos. J. Cell Biol., 109:2471-2479.
65. Sawaya, R., Tofilon, P.J., Mohanam, S., Aliosman, F., Liotta, L.A., Stetlerstevenson, W.G., and Rao, J.S. (1994) Induction of tissue-type plasminogen-activator and 72-kda type-IV collagenase by ionizingradiation in rat astrocytes. Int. J. Cancer, 56:214-218.
66. Seeds, N.W., Verrall, S., Friedman, G., Hayden, S., Gadotti, D., Haffke, S., Christensen, K., Gardner, B., McGuire, P., and Krystosek, A. (1992) Plasminogen activators and plasminogen activator inhibitors in neural development. Ann. NY Acad. Sci., 667:32-40.
67. Smith-Thomas, L., Fok-Seang, J., Stevens, J., Du, J., Muir, E., Faissner, A., Geller, H.M., Rogers, J.H., and Fawcett, J.W. (1994) An inhibitor of neurite outgrowth produced by astrocytes. J. Cell Sci., 107:1687-1695.
68. Smith-Thomas, L., Stevens, J., Fok-Seang, J., Muir, E., Faissner, A., Rogers, J.H., and Fawcett, J.W. (1995) Increased axon regeneration in astrocytes grown in the presence of proteoglycan synthesis inhibitors. J. Cell Sci., 108:1307-1315.
69. Sordat, B., Reiter, L., and Cajot, J.F. (1990) Modulation of the malignant phenotype with the urokinase-type plasminogen activator and the type I plasminogen activator inhibitor. Cell Differ. Dev., 32:277-285.
70. Sumi, Y., Dent, M.A.R., Owen, D.E., Seeley, P.J., and Morris, R.J. (1992) The expression of tissue and urokinase-type plasminogen activators in neural development suggests different modes of proteolytic involvement in neuronal growth. Development, 116:625-637.
71. Towle, M.J., Lee, A., Maduakor, E.C., Schwartz, C.E., Bridges, A.J., and Littlefield, B.A. (1993) Inhibition of urokinase by 4-substituted benzothiophene-2-carboxamidines: An important new class of selective synthetic urokinase inhibitor. Cancer Res., 53:2553-2559.
72. Tranque, P., Naftolin, F., and Robbins, R. (1994) Differential regulation of astrocyte plasminogen activators by insulin-like growth factor-I and epidermal growth factor. Endocrinology, 134:2606-2613.
73. Tsuboi, R., Sato, Y., and Rifkin, D.B. (1990) Correlation of cell migration, cell invasion, receptor number, proteinase production, and basic fibroblast growth factor levels in endothelial cells. J. Cell Biol., 110:511-517.
74. Valinsky, J.E., and Le Douarin, N.M. (1985) Production of plasminogen activator by migrating cephalic neural crest cells. EMBO J., 4:1403-1406.
75. Vaughan, P.J., and Cunningham, D.D. (1993) Regulation of protease nexin-1 synthesis and secretion in cultured brain cells by injury-related factors. J. Biol. Chem., 268:3720-3727.
76. Wei, Y., Waltz, D.A., Rao, N., Drummond, R.J., Rosenberg, S., and Chapman, H.A. (1994) Identification of the urokinase receptor as an adhesion receptor for vitronectin. J. Biol. Chem., 269:32380-32388.
77. Wei, Y., Lukashev, M., Simon, D.I., Bodary, S.C., Rosenberg, S., Doyle, M.V., and Chapman, H.A. (1996) Regulation of integrin function by the urokinase receptor. Science, 273:1551-1555.
78. Yamamoto, M., Sawaya, R., Mohanam, S., Bindal, A.K., Bruner, J.M., Oka, K., Rao, V.H., Tomonaga, M., Nicolson, G.L., and Rao, J.S. (1994b). Expression and localization of urokinase-type plasminogen activator in human astrocytomas in vivo. Cancer Res., 54:3656-3661.