No evidence for involvement of the interleukin-10 -592 promoter polymorphism in genetic susceptibility to primary biliary cirrhosis

Journal of Hepatology

Volumn 28, Issue 5, 1998, Pages 820-823

  Zappala, Francesco ^a   Grove, Jane ^a   Watt, Fiona E ^a   Daly, Ann K ^a   Day, Christopher P ^a   Bassendine, Margaret F ^a   Jones, David E J ^a,b  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

^b NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

Autoimmunity; Biliary; Genetics; Human; Interleukin 10; Liver cirrhosis

Indexed keywords

ADULT; AGED; ALLELE; ARTICLE; AUTOIMMUNITY; CHOLESTASIS; FEMALE; GENE LOCUS; GENETIC LINKAGE; GENETIC POLYMORPHISM; GENETIC SUSCEPTIBILITY; GENETICS; HUMAN; IMMUNOMODULATION; LIVER CIRRHOSIS; MAJOR CLINICAL STUDY; MAJOR HISTOCOMPATIBILITY COMPLEX; MALE; POLYMERASE CHAIN REACTION; PRIMARY BILIARY CIRRHOSIS; PRIORITY JOURNAL; PROMOTER REGION;

EID: 0032079538     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-8278(98)80232-8     Document Type: Article

References (29)

1. Kaplan M. Primary biliary cirrhosis. N Engl J Med. 335:1996;1570-1579.
2. Bach N, Schaffner F. Familial primary biliary cirrhosis. J Hepatol. 20:1994;698-701.
3. Brind AM, Bray GP, Portmann BC, Williams R. Prevalence and pattern of familial disease in primary biliary cirrhosis. Gut. 36:1995;615-617.
4. Gregory WL, Mehal WZ, Dunn AN, Cavanagh G, Idle JR, James OFW, et al. Primary biliary cirrhosis: contribution of HLA class II allele DR8. Q J MEd. 86:1993;393-399.
5. Underhill JA, Donaldson PT, Bray GP, Doherty DG, Portmann BC, Williams R. Susceptibility to primary biliary cirrhosis is associated with the HLA-DR8-DQB1*0402 haplotype. Hepatology. 16:1992;1404-1408.
6. Onishi S, Sakamaki T, Maeda T, Iwamura S, Tomita A, Saibara T, et al. DRB1*0803 increases the susceptibility of Japanese to primary biliary cirrhosis. J Hepatol. 21:1994;1053-1060.
7. Manns MP, Bremm A, Schneider PM, Notghi A, Gerken G, Prager-Eberle M, et al. HLA DRw8 and complement C4 deficiency as risk factors in primary biliary cirrhosis. Gastroenterology. 101:1991;1367-1373.
8. Begovich AB, Klitz W, Moonsamy PV, Van de Water J, Peltz G, Gershwin ME. Genes within the HLA class II region confer disposition and resistance to primary biliary cirrhosis. Tissue Antigens. 43:1994;71-77.
9. Underhill JA, Donaldson PT, Doherty DG, Manabe K, Williams R. HLA DPB polymorphism in primary sclerosing cholangitis and primary biliary cirrhosis. Hepatology. 21:1995;959-962.
10. Seki T, Kiyosawa K, Ota M, Furuta S, Fukushima H, Tanaka E, et al. Association of primary biliary cirrhosis with human leukocyte antigen DPB1*0501 in Japanese patients. Hepatology. 18:1993;73-78.
11. Mehal WZ, Gregory WL, Lo YMD, Cross SJ, Fleming KA, Bassendine MF, et al. Defining the immunogenetic susceptibility to primary biliary cirrhosis. Hepatology. 20:1994;1213-1219.
12. Gordon MA, Gleeson D, Oppenheim E, di Giovine FS, Camp NC, Duff GW. Tumour necrosis factor genetic polymorphisms and primary biliary cirrhosis. Hepatology. 24:1996;166A.
13. Abbas AK, Murphy KM, Sher A. Functional density of helper T-lymphocytes. Nature. 383:1996;787-793.
14. Liblau RS, Singer SM, McDevitt HO. Th1 and Th2 CD4+ T cells in the pathogenesis of organ-specific autoimmune diseases. Immunol Today. 16:1995;34-38.
15. Mitchell SA, Fleming K, Chapman R. Decreased interleukin-10 expression in primary sclerosing cholangitis and primary biliary cirrhosis: a role for IL-10 in the pathogenesis? Hepatology. 26:1997;442A.
16. Hobbs K, Mascali J, Klemm D, Borish L. Contribution of the interleukin (IL)-10 promoter polymorphism to allergic inflammation. J Allergy Clin Immunol. 97:1996;714.
17. Turner DM, Williams DM, Sankaran D, Lazarus M, Sinnott PJ, Hutchinson IV. An investigation of polymorphism in the interleukin-10 gene promoter. Eur J Immunogen. 24:1997;1-8.
18. Scheuer P. Primary biliary cirrhosis. Proc R Soc Med. 60:1967;1257-1260.
19. Bogdan C, Vodovotz Y, Nathan C. Macrophage deactivation by interleukin 10. J Exp Med. 174:1991;1549-1555.
20. Fowell D, Mason D. Evidence that the T-cell repertoire of normal rats contains cells with the potential to cause diabetes. Characterisation of the T-cell subset that inhibits the autoimmune potential. J Exp Med. 177:1993;627-636.
21. Kuhn R, Lohler J, Rennick D, Rajewsky K, Muller W. Interleukin-10 deficient mice develop chronic enterocolitis. Cell. 75:1993;263-274.
22. Segal BM, Shevach EM. IL-12 unmasks latent autoimmune disease in resistant mice. J Exp Med. 184:1996;771-775.
23. Mignon-Godefroy K, Rott O, Brazilett M-P, Charriere J. Curative and protective effects of IL-10 in experimental auto-immune thyroiditis (EAT). Evidence for IL-10-enhanced cell death in EAT. J Immunol. 154:1995;6634-6643.
24. Berg PA, Klein R, Rocken M. Cytokines in primary biliary cirrhosis. Semin Liver Dis. 17:1997;115-123.
25. Van de Water J, Ansari A, Prindiville T, Coppel RL, Ricalton N, Kotzin BL, et al. Heterogeneity of autoreactive T-cell clones specific for the E2 component of the pyruvate dehydrogenase complex in primary biliary cirrhosis. J Exp Med. 181:1995;723-733.
26. Harada K, Van de Water J, Leung PS, Coppel RL, Ansari A, Nakanuma Y, et al. In situ nucleic acid hydridization of cytokines in primary biliary cirrhosis: predominance of the Th1 subset. Hepatology. 25:1997;791-796.
27. Shindo M, Mullin GE, Braun-Elwert L, Bergasa NV, Jones EA, James SP. Cytokine mRNA expression in the liver of patients with primary biliary cirrhosis (PBC) and chronic hepatitis B (CHB). Clin Exp Immunol. 105:1996;254-259.
28. Jones DEJ, Palmer JM, Leon MP, Yeaman SJ, Bassendine MF, Diamond AG. T-cell responses to tuberculin-purified protein derivative in primary biliary cirrhosis: evidence for defective T-cell function. Gut. 40:1997;277-283.
29. Mascali J, Borish L, Aarons A, Rumbyrt J, Klemm D. Sequence and characterization of the human interleukin (IL)-10 promoter. J Allergy Clin Immunol. 95:1995;343.