High performance liquid chromatographic determination of mercapturic acids in urine of rats administered with m- or p-xylene

Chemosphere

Volumn 36, Issue 11, 1998, Pages 2491-2495

  Tsujimoto, Yuji ^a   Noda, Tsutomu ^a   Moriwaki, Hiroshi ^a   Tanaka, Masanobu ^a  

^a OSAKA CITY INSTITUTE OF PUBLIC HEALTH AND ENVIRONMENTAL SCIENCES   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; XYLENE;

ANIMAL EXPERIMENT; ARTICLE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MALE; NONHUMAN; RAT; TOXICOKINETICS; URINALYSIS; URINARY EXCRETION;

ACETYLCYSTEINE; ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; INJECTIONS, INTRAPERITONEAL; MALE; RATS; RATS, WISTAR; SULFIDES; XYLENES;

ANIMALIA;

EID: 0032079257     PISSN: 00456535     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0045-6535(97)10216-8     Document Type: Article

References (7)

1. 1) R.F. Williams : Detoxification mechanism, Chapman and Hall, London(1959).
2. 2) J.R. Caperos and J.G. Fernandez : Simultaneous determination of toluene and xylene metabolites in urine by gas chromatography, Br.J.Med., 34, 229-233(1977).
3. 3) M. Ogata, Y. Yamazaki, R. Sugihara, Y. Shimada and T. Megro : Qunatitation of urinary o-xylene metabolites of rats and human beings by high performance liquid chromatography, Int.Arch. Occup.Environ.Health, 46, 127-139(1980).
4. 4) T. Sakai, Y. Niinuma, S. Yanagihara and K. Ushio : Simultaneous determination of hippuric acid and o-, m-and p-methyl hippuric acids in urine by high-performance liquid chromatography, J. chromatogr., 276, 182-188(1983).
5. 5) R. van Doorn, R.P. Bos, R.M.E. Brouns, Ch.-M. Leijdekkers, and P.Th. Henderson : Effect of toluene and xylenes on liver glutathione and their urinary excretion as mercapturic acids in the rat, Arch.Toxicol., 43, 293-304(1980).
6. 6) M. Tanaka, M. Shimizu and Y. Tsujimoto : High-performance liquid chromatographic determination of urinary mercapturic acids in the rat, J.Chromatogr., 526, 289-292(1990).
7. 7) M. Tanaka, T. Noda, H. Moriwaki and Y. Tsujimoto : Synthesis and Chracterization of m-and p-methylbenzyl mercapturic acids derived from m-and p-xylenes, Chemosphere, in press.