Studies on thymic epithelial cells in vitro

Developmental and Comparative Immunology

Volumn 22, Issue 3, 1998, Pages 367-377

  Anderson, Kim L ^a   Moore, Nel C ^a,b   McLoughlin, Deirdre E J ^a   Jenkinson, Eric J ^a   Owen, John J T ^a  

^a UNIVERSITY DEPARTMENT OF MEDICINE   (United Kingdom)

^b ASTRAZENECA   (United Kingdom)

Author keywords

Cytokeratin; Epithelial cell; Gene expression; Monolayer; Positive selection; Proliferation; Reaggregate; Thymus

Indexed keywords

ANIMAL CELL; ANTIGEN EXPRESSION; ARTICLE; CELL CULTURE; CELL MATURATION; CELL PROLIFERATION; CONTROLLED STUDY; CYTOMETRY; EMBRYO; EMBRYO DEVELOPMENT; GENE EXPRESSION; MOUSE; NONHUMAN; PRIORITY JOURNAL; THYMOCYTE; THYMUS FUNCTION;

EID: 0032079168     PISSN: 0145305X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0145-305X(98)00011-1     Document Type: Article

References (31)

1. 1. Anderson, G., Jenkinson, E. J., Moore, N. C. and Owen, J. J. T. MHC class II-positive epithelium and mesenchyme cells are both required for T-cell development in the thymus. Nature, 1993, 362, 70-73.
2. + thymocytes in vitro. J. Exp. Med., 1994, 179, 2027-2031.
3. 3. Larsson, L., Timms, E., Blight, K., Restall, D. E., Jat, P. S. and Fischer, A. G. Characterisation of murine thymic stromal cell lines immortalised by temperature sensitive simian virus 40 large T or adenovirus 5 Ela. Dev. Immunol., 1991, 1, 279-293.
4. 4. Imaizumi, A., Goldschneider, I. and Yoshida, T. Reproducible procedures for establishing mouse thymic stromal cell lines. Cell. Immunol., 1993, 150, 81-89.
5. 5. Georgiou, H. M. and Constantinou, D. Production and characterisaton of mouse thymic epithelial cell clones. Immunol. and Cell Biology, 1994, 72, 57-67.
6. 6. Ritter, M. A. and Crispe, I. N., In The Thymus, ed. D. Male. In Focus Series, IRL Press, 1992.
7. 7. Boyd, R. L., Tucek, C. L., Godfrey, D. I., Izon, D. J., Wilson, T. J., Davidson, N. J., Bean, A. G. D., Ladyman, H. M., Ritter, M. A. and Hugo, P. The thymic microenvironment. Immunol. Today, 1993, 14, 445-459.
8. 8. Jenkinson, E. J. and Anderson, G. Fetal thymic organ cultures. Curr. Opin. Immunol., 1994, 6, 293-297.
9. 9. Anderson, G. and Jenkinson, E. J. The role of the thymus during T-lymphocyte development in vitro. Seminars in Immunol., 1995, 7, 177-183.
10. 10. Carayon, P. and Bord, A. Identification of DNA-replicating lymphocyte subsets using a new method to label the bromo-deoxyuridine incorporated into the DNA. J. Immunol. Meth., 1992, 147, 225-230.
11. 11. Lucas, B., Vasseur, F. and Penit, C. Production, selection and maturation of thymocytes with high surface density of TCR. J. Immunol., 1994, 153, 53-62.
12. 12. Tough, D. F. and Sprent, J. Turnover of naive and memory T cells. J. Exp. Med., 1994, 179, 1127-1135.
13. 13. Ernst, B., Surh, C. D. and Sprent, J. Thymic selection and cell division. J. Exp. Med., 1995, 182, 961-971.
14. 14. Jenkinson, E. J., Anderson, G. and Owen, J. J. T. Studies on T-cell maturation in defined thymic stromal cell populations. J. Exp. Med., 1992, 176, 845-853.
15. 15. Moore, N. C., Anderson, G., Smith, C. A., Owen, J. J. T. and Jenkinson, E. J. Analysis of cytokine gene-expression in subpopulations of freshly isolated thymocyte and thymic stromal cells using semiquantitative polymerase chain-reaction. Eur. J. Immunol., 1993, 23, 922-927.
16. 16. Gratzner, H. G. Monoclonal antibody to 5-Bromo and 5-Iododeoxyuridine: a new reagent for detection of DNA replication. Science, 1982, 218, 474-479.
17. 17. Dolbeare, F., Gratzner, H. G., Pallavicini, M. G. and Gray, W. Flow cytometric measurement of total DNA content and incorporated bromodeoxyuridine. Proc. Natl. Acad. Sci. USA, 1983, 80, 5573-5577.
18. 18. Bhatia, S. K., Tygrett, L. T., Grabstein, K. H. and Waldschmidt, T. J. The effect of in vivo IL-7 deprivation on T-cell maturation. J. Exp. Med., 1995, 181, 1399-1409.
19. 19. von Freeden-Jeffry, U., Vieira, P., Lucian, L. A., McNeil, T., Burdach, S. E. G. and Murray, R. Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a nonredundant cytokine. J. Exp. Med., 1995, 181, 1519-1526.
20. 20. Moore, T. A., von Freeden-Jeffrey, U., Murray, R. and Zlotik, A. Inhibition of γδ T-cell development and early thymocyte maturation in IL-7 -/-mice. J. Immunol., 1996, 157, 2366-2373.
21. 21. Chang, A. C., Salomon, D. R., Wadsworth, S., Hong, M-J. P., Mojcik, C. F., Otto, S., Shevach, E. M. and Coligan, J. E. α3β1 and α6β1 integrins mediate laminin/merosin binding and function as costimulatory molecules for human thymocyte proliferation. J. Immunol., 1995, 154, 500-510.
22. 22. Takeichi, M. Morphogenetic roles of classic cadherins. Curr. Opin. Cell. Biol., 1995, 7, 619-627.
23. 23. Penit, C., Lucas, B., Vasseur, F., Rieker, T. and Boyd, R. L. Thymic medulla epithelial cells acquire specific markers by post-mitotic maturation. Dev. Immunol., 1996, 5, 25.
24. 24. Ritter, M. A. and Boyd, R. L. Development in the thymus: it takes two to tango. Immunol. Today, 1993, 14, 462-469.
25. 25. Meilin, A., Shoham, J., Schreiber, L. and Sharabi, Y. The role of thymocytes in regulating thymic epithelial cell growth and function. Scan. J. Immunol., 1995, 42, 185-190.
26. + into more mature stages by a thymic stromal cell clone. Proc. Natl. Aca. Sci. USA., 1990, 87, 2750-2754.
27. 27. Saunders, D. J., Georgiou, H. M. and Wu, L., Shortman, K. Induction of limited growth and differentiation of early thymic precursor cells by thymic epithelial cell lines. Immunol. Lett., 1995, 47, 45-51.
28. 28. Lin, C. Q. and Bissell, M. J. Multi-faceted regulation of cell differentation by extracellular matrix. FASEB J., 1993, 7, 737-743.
29. 29. Nehls, M., Pfieifer, D., Schorpp, M., Hedrich, H. and Boehm, T. New member of the winged helix protein family disrupted in mouse and rat nude mutations. Nature, 1994, 372, 103-107.
30. 30. Segre, J. A., Nemhauser, J. L., Taylor, B. A., Nadeau, J. H. and Lander, E. S. Positional cloning of the nude locus-genetic, physical and transcriptional maps of the region and mutations in the mouse and rat. Genomics, 1995, 28, 549-559.
31. 31. Nehls, M., Kyewski, B., Messerle, M., Waldschutz, R., Schuddekopf, K., Smith, A. J. H. and Boehm, T. 2 genetically separable steps in the differentation of thymic epithelium. Science, 1996, 272, 886-889.