Prolongation of cardiac graft survival with anti-CD4Ig plus hCTLA4Ig in primates

Journal of Surgical Research

Volumn 76, Issue 2, 1998, Pages 174-178

  Krieger, Nancy R ^a   Yuh, David ^a   McIntyre, W Burley ^a   Flavin, Thomas F ^a   Yin, Dengping ^a   Robbins, Robert ^a   Fathman, C Garrison ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Allograft survival; Anti CD4; Cardiac transplant; CTLA4Ig; Rhesus monkeys

Indexed keywords

CD4 ANTIGEN;

ALLOGRAFT; ANIMAL EXPERIMENT; ANIMAL MODEL; CELL PROLIFERATION; CONFERENCE PAPER; CONTROLLED STUDY; GRAFT REJECTION; GRAFT SURVIVAL; HEART GRAFT; IMMUNE RESPONSE; IMMUNOTHERAPY; NONHUMAN; PRIORITY JOURNAL; RECIPIENT; RHESUS MONKEY; T LYMPHOCYTE ACTIVATION; TARGET CELL;

EID: 0032077806     PISSN: 00224804     EISSN: None     Source Type: Journal    
DOI: 10.1006/jsre.1998.5318     Document Type: Conference Paper

References (32)

1. Shizuru J. A., Seydel K. B., Flavin T. F., Wu A. P., Kong C. C., Hoyt E. G., Fujimoto N., Billingham M. E., Starnes V. A., Fathman C. G. Induction of donor-specific unresponsiveness to cardiac allografts in rats by pretransplant anti-CD4 monoclonal antibody therapy. Transplantation. 50:1990;36.
2. Shizuru J. A., Gregory A. K., Tien-Bao C., Fathman C. G. Islet allograft survival after a single course of treatment of recipient with antibody to L3T4. Science. 237:1987;278.
3. Alters S. E., Shizuru J. A., Ackerman J., Grossman D., Seydel K. B., Fathman C. G. Anti-CD4 mediates clonal anergy during transplantation tolerance induction. J. Exp. Med. 173:1991;491.
4. Alters S. E., Song H. K., Fathman C. G. Evidence that clonal anergy is induced in thymic migrant cells after anti-CD4-mediated transplantation tolerance. Transplantation. 56:1993;633.
5. Yagita H., Nakamura T., Karasuyama H., Okumura K. Monoclonal antibodies specific for murine CD2 reveal its presence on B as well as T cells. Proc. Natl. Acad. Sci. USA. 86:1989;645.
6. Yin D. P., Fathman C. G. CD4-positive suppressor cells block allotransplant rejection. J. Immunol. 154:1995;6339.
7. Goronzy J., Weyand C. M., Fathman C. G. Long-term humoral unresponsiveness in vivo induced by treatment with monoclonal antibody against L3T4. J. Exp. Med. 164:1986;911.
8. Wofsy D., Seaman W. W. Successful treatment of autoimmunity in NZB/NZW F1 mice with mAb to L3T4. J. Exp. Med. 161:1985;378.
9. Ranges G. E., Sriram S., Cooper S. M. Prevention of type II collagen-induced arthritis by in vivo treatment with anti-L3T4. J. Exp. Med. 162:1985;1105.
10. Brostoff S. N., Mason D. N. Experimental allergic encephalomyelitis: Successful treatment in vivo with a monoclonal antibody that recognizes T helper cells. J. Immunol. 133:1984;1938.
11. Shizuru J. A., Taylor-Edwards C., Banks B. A., Gregory A. K., Fathman C. G. Immunotherapy of the nonobese diabetic mouse: Treatment with an antibody to T-helper lymphocytes. Science. 24:1988;659.
12. Van Gool S. W., de Boer M., Ceuppens J. L. The combination of anti-B7 monoclonal antibody and Cyclosporin A induces alloantigen-specific anergy during a primary mixed lymphocyte reaction. J. Exp. Med. 179:1994;715.
13. Turka L. A., Linsley P. S., Lin H. T-cell activation by the CD28 ligand B7 is required for cardiac allograft rejection in vivo. Proc. Natl. Acad. Sci. USA. 89:1992;11102.
14. Lacy P., Davie J., Finke E. Prolongation of islet xenograft survival without continuous immunosuppression. Science. 209:1980;283.
15. Lin H., Bolling S. F., Linsley P. S. Long-term acceptance of major histocompatibility complex mismatched cardiac allografts induced by CTLA4Ig plus donor-specific transfusion. J. Exp. Med. 178:1993;1801.
16. Walunas T. L., Lenschow D. J., Baker C. Y., Linsley P. S., Freeman G. J., Green J. M., Thompson C. B., Bluestone J. A. CTLA-4 can function as a negative regulator of T cell activation. Immunity. 1:1994;405.
17. Kaufman D., Kong C., Shizuru J., Gregory A., Fathman C. G. Use of anti-L3T4 and anti-Ia treatments for prolongation of xenogeneic islet transplants. Transplantation. 46:1988;210.
18. Krummel M. F., Allison J. P. CD28 and CTLA4 have opposing effects on the response of T cells to stimulation. J. Exp. Med. 182:1995;459.
19. Linsley P. S., Brady W., Urnes M., Grosmaire L. S., Damle N. K., Ledbetter J. A. CTLA-4 is a second receptor for the B cell activation antigen B7. J. Exp. Med. 174:1991;561.
20. Pearson T. C., Madsen J. C., Larsen C. P. Induction of transplantation tolerance in adults using donor antigen and anti-CD4 monoclonal antibody. Transplantation. 54:1992;475.
21. Pearson T. C., Alexander D. Z., Winn J. Transplantation tolerance induced by CTLA4Ig. Transplantation. 57:1994;1701.
22. Lenschow D. J., Zeng Y., Thistlethwaite R. Long-term survival of xenogeneic pancreatic islet grafts induced by CTLA4Ig. Science. 257:1992;789.
23. Wallace P. M., Johnson J. S., MacMaster J. F. CTLA4Ig treatment ameliorates the lethality of murine graft-vs-host disease across major histocompatibility complex barriers. Transplantation. 58:1994;602.
24. Finck B. K., Linsley P. S., Wofsy D. Treatment of murine Lupus with CTLA4Ig. Science. 265:1994;1225.
25. Yin D. P., Fathman C. G. Induction of tolerance to heart allografts in high responder rats by combining anti-CD4 with CTLA4Ig. J. Immunol. 155:1995;1655.
26. Yin D. P., Sankary H. N., Williams J., Krieger N., Fathman C. G. Induction of tolerance to small bowel allografts in high-responder rats by combing anti-CD4 with CTLA4-Ig. Transplantation. 62:1996;1537.
27. Yin D. P., Fathman C. G. Tissue-specific effects of anti-CD4 therapy in induction of allograft unresponsiveness in high and low responder rats. Transplant Immunol. 3:1995;258.
28. Cosimi A. B. Anti-T-cell monoclonal antibodies in transplantation therapy. Transplant Proc. 25:1983;1889.
29. Jonker M., Goldstein G., Balner H. Effects of in vivo administration of monoclonal antibodies specific for human T-cell subpopulations on the immune system in a rhesus monkey model. Transplantation. 35:1983;52.
30. Jonker M., Neuhaus P., Zurcher C., Fucello A., Goldstein G. OKT4 and OKT4a antibody therapy as immunosuppression for kidney transplantation in rhesus monkeys. Transplantation. 39:1985;247.
31. Cosimi A. B., Burton R. C., Kung P. C., Colvin R., Goldstein G., Lifter J., Rhodes W., Russell P. S. Evaluation in primate renal allograft recipients of monoclonal antibody to human T-cell subclasses. Transplant. Proc. 13:1981;499.
32. Rose L. M., Ellsworth C. A., Surkatt H. Anti-CD4 monoclonal antibody treatment of experimental allergic encephalomyelitis in longtailed macaques. Ann. NY Acad. Sci. 540:1988;581.