Antispermatogenic and androgenic activities of Momordica charantia (Karela) in albino rats

Journal of Ethnopharmacology

Volumn 61, Issue 1, 1998, Pages 9-16

  Naseem, Mulla Zehera ^a   Patil, Srinivas Reddy ^a   Patil, Somnath Reddy ^a   Ravindra, ^a   Patil, Saraswati B ^a  

^a GULBARGA UNIVERSITY   (India)

Author keywords

Androgenic; Antispermatogenic; Momordica charantia

Indexed keywords

ANDROGEN; ANTISPERMATOGENIC AGENT; CHOLESTEROL; GLYCOGEN; LIPID; MOMORDICA CHARANTIA EXTRACT; PLANT EXTRACT; PROTEIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL COUNT; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DRUG ISOLATION; DRUG POTENCY; EPIDIDYMIS; GLYCOGEN ANALYSIS; INTRAPERITONEAL DRUG ADMINISTRATION; LEVATOR ANI MUSCLE; LIPID STORAGE; MALE; MORPHOMETRICS; NONHUMAN; ORAL DRUG ADMINISTRATION; ORGAN WEIGHT; PLANT SEED; PROSTATE; PROTEIN CONTENT; RAT; SEMINAL VESICLE; SPERMATID; SPERMATOCYTE; SPERMATOGENESIS; SPERMATOGONIUM; SPERMATOZOON; SPERMATOZOON COUNT; STEROIDOGENESIS;

ALKANES; ANDROGENS; ANIMALS; ANTISPERMATOGENIC AGENTS; BENZENE; CHOLESTEROL; EPIDIDYMIS; ETHANOL; MALE; ORGAN SIZE; PLANT EXTRACTS; PLANTS, MEDICINAL; PROSTATE; RATS; SEEDS; SEMINAL VESICLES; SPERM COUNT; SPERMATIDS; SPERMATOCYTES; SPERMATOZOA;

EID: 0032077193     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-8741(98)00006-3     Document Type: Article

References (27)

1. Akbarsha M.A., Manivannan B., Shahual Hamid K., Vijayan B. Effects of Andrographis paniculata (Nees) in male albino rat. Ind. J. Exp. Biol. 28:1990;421-425.
2. Bhargava S.K. Antifertility agents from plants. Fitoterapia. LIX(3):1988;163-177.
3. Caroll N.V., Langelly R.W., Row R.H. Glycogen determination in liver and muscle by use of anthrone reagent. J. Biol. Chem. 26:1956;583-593.
4. Chaterjee, A., Adhikari, P., Banerji, J., Choudhary, C., Jana, S., Sen Gupta, A., 1994. Antifertility effect of Piper beetle Linn. (Stalk) in Adult Male Rats 71, 81.
5. Chopra R.N., Chopra I.C., Handa K.L., Kapur L.D. Chopra's Indigenous Drugs of India. 1958;49 U.N. Dhur and Sons, Calcutta.
6. Chopra I.C., Handa K.L., Kapur C.D. R.N. Chopra's Indigenous Drugs of India. 2nd Edn:1982;Academic Publications, Calcutta, New Delhi. Reprint 1982.
7. Connel G.M., Eik-Nes K.B. Testosterone production by rabbit testis slices. Steroids. 12:1968;507-516.
8. Dorrington J.H., Armstrong D.T. Follicle stimulating hormone stimulates estradiol-17β synthesis in cultured Sertoli cells. Proc. Natl. Acad. Sci. USA. 72:1975;2677.
9. Holt J.A., Kelcu R.P., Payne A.H. In vitro effect of rat LH and FSH and HCG on androgen (A) and estrogen (E) release from decapsulating rat testis. Proc. Annu. Meet. Soc. Study Report. 6:1973;58.
10. Johnson B.J., Ewing Follicle stimulating hormone and the regulation of testosterone secretion in rabbit testes. Science. 173:1971;635.
11. Kamboj V.P. A review of Indian medicinal plants with interceptive activity. Ind. J. Med. Res. 87:1988;336-355.
12. Kantak N.M, Gogate M.G. Effect of short term administration of Tulsi (Occimum Sanctum) Linn. on reproductive behaviour of adult male rats. Ind. J. Physiol. Pharmacol. 36(2):1992;109.
13. Kholkute S.D. Effects of Hibiscus rosa sinensis on spermatogenesis and accessory reproductive organs in rats. Plant Med. 31:1977;127-130.
14. Lohiya N.K., Goyal R.B. Antifertility investigations on the crude chloroform extract of Carica papaya seeds in male albino rats. Ind. J. Exp. Biol. 30:1991;1051-1054.
15. Lowry D.H., Rosenbrough N.J., Farr A.L., Randall R.J. Protein measurement with folin reagent. J. Biol. Chem. 193:1961;265-275.
16. Mann T., Ludwak-Mann C. Male Reproductive Function and Semen. 1981;139-144 Springer, Berlin.
17. Murugavel T, Akbarshah M.A. Antispermatogenic effect of Vinca rosea Linn leaves in male albino mice. Ind. J. Exp. Biol. 29:1991;810-812.
18. Nadkarni K.M, Nadkarni A.K. Indian Material Medica. I:1976;Popular Prakashan, Bombay.
19. Peters, J.P., Vanslyke, D.D., 1946. In: Williams, Wilkins. (Eds.), Quantitative Clinical Chemistry, Vol. I, Baltimore.
20. Prakash A.O., Gupta R.B., Mathur R. Effect of oral administration of 42 indigenous plant extracts on early and late pregnancy in albino rats. Probe. 27:1978;315.
21. Purandhare, V.T., Kholkute, S.D., Gurjar, A., Usha, M.J., Dattatreya, Murthy, B., Shelh, A.R., Swamy, Y.R., Jayaraman, S., Safia, R.M., 1979. Semen analysis and hormonal levels in Bonnet macaques administered Embelia ribes berries, an indigenous plant having contraceptive activity, Ind. J. Exp. Biol. 17 (9), 935.
22. Rao M.V. Effect of alcoholic extract of Solanum xanthocarpum seeds in adult male rats. Ind. J. Exp. Biol. 26:1988;95-98.
23. Reddy C.M., Murthy D.R.K., Patil S.B. Antispermatogenic and androgenic activities of various extracts of Hibiscus rosa sinensis in albino mice. Ind. J. Exp. Biol. 35:1997;1170-1174.
24. Satyavati G.V. Pharmacology of medicinal plants and other natural products. Das P.K., Dhawan B.N. Current Research in Pharmacology in India (1975-82). 1984;119 Indian National Science Academy, New Delhi.
25. Saxena S.K. Study of antifertility effect of the leaves of Momordica Linn. (laveler). Ind. J. Physiol. Pharmacol. 15:1971;79.
26. Soez J.M. Leydig cells: endocrine, paracine and autocrine regulation. Endocr. Rev. 15:1994;574-626.
27. Wyrobek A.J., Bruce W.R. Chemical induction of sperm abnormalities in mice. Proc. Natl. Acad. Sci. USA. 72:1975;4425.