Chiral separations of pharmaceuticals using capillary electrochromatography (CEC): An overview

Journal of Capillary Electrophoresis and Microchip Technology

Volumn 5, Issue 3-4, 1998, Pages 143-151

  Hatajik, Todd D ^a   Brown, Phyllis R ^b  

^a PFIZER INC   (United States)

^b UNIVERSITY OF RHODE ISLAND   (United States)

Author keywords

Chiral separations; Electrochromatography; Enantiomers; Pharmaceuticals

Indexed keywords

ACETONITRILE; CELLULOSE; CHLORTALIDONE; CYCLODEXTRIN; NAPROXEN;

CAPILLARY ELECTROCHROMATOGRAPHY; CHIRALITY; DRUG METABOLISM; DRUG POTENCY; DRUG TOXICITY; ELECTROPHORETIC MOBILITY; ENANTIOMER; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MOLECULAR DYNAMICS; PARTITION CHROMATOGRAPHY; REVIEW; SEPARATION TECHNIQUE; CAPILLARY ELECTROPHORESIS; METHODOLOGY;

ELECTROPHORESIS, CAPILLARY;

EID: 0032056605     PISSN: 10795383     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (24)

1. Schweitz L, Andersson LI, Nilsson S. Capillary electrochromatography with predetermined selectivity obtained through molecular imprinting. Anal Chem 1997; 69:1179-83.
2. Fanali S. Identification of chiral drug isomers by capillary electrophoresis. J Chromatogr A 1996; 735:77-121.
3. 1-acid glycoprotein chiral stationary phase. Anal Chem 1993; 65:3684-90.
4. Schurig V, Jung M, Mayer S, Fluck M, Negura S, Jakubetz H. Unified enantioselective capillary chromatography on a Chirasil-DEX stationary phase: advantages of column miniaturization. J Chromatogr A 1995; 694:119-28.
5. Jakubetz H, Czesla H, Schurig V. On the feasibility of miniaturized enantiomeric separation by liquid chromatography (OTLC) and open tubular electrochromatography (OTEC). J Microcol Sep 1997; 9:421-31.
6. Lelievre F, Yan C, Zare RN, Gareil P. Capillary electrochromatography: operating characteristics and enantiomeric separations. J Chromatogr A 1996; 723:145-56.
7. Hage DS. Chiral separations in capillary electrophoresis using proteins as stereoselective binding agents. Electrophoresis 1997; 18:2311-21.
8. Wolf C, Spence PL, Pirkle WH, Derrico EM, Cavender DM, Rozing GP. Enantioseparations by electrochromatography with packed capillaries. J Chromatogr A 1997; 782:175-9.
9. Peters EC, Lewandowski K, Petro M, Svec F, Frechet JMJ. Chiral electrochromatography with a "moulded" rigid monolithic capillary column. Anal Comm 1998; 35:83-6.
10. Francotte E, Jung M. Enantiomer separation by open-tubular liquid chromatography and electrochromatography in cellulose-coated capillaries. Chromatographia 1996; 42(9/10):521-7.
11. Maruska A, Pyell U. Capillary electrochromatography: normal-phase mode using silica gel and cellulose-based packing materials. J Chromatogr A 1997; 782:167-74.
12. Wright PB, Lister AS, Dorsey JG. Behavior and use of nonaqueous media without supporting electrolyte in capillary electrophoresis and capillary electrochromatography. Anal Chem 1997; 69:3251-9.
13. Nilsson S, Schweitz L, Petersson M. Three approaches to enantiomer separation of β-adrenergic antagonists by capillary electrochromatography. Electrophoresis 1997; 18:884-90.
14. Bruggemann O, Freitag R, Whitcombe MJ, Vulfson EN. Comparison of polymer coatings of capillaries for capillary electrophoresis with respect to their applicability to molecular imprinting and electrochromatography. J Chromatogr A 1997; 781:43-53.
15. Lin JM, Nakagama T, Uchiyama K, Hobo T. Capillary electrochromatographic separation of amino acid enantiomers using on-column prepared molecularly imprinted polymer. J Pharm Biomed Anal 1997; 15:1351-8.
16. Lin JM, Nakagama T, Uchiyama K, Hobo T. Enantioseparation of D,L-phenylalanine by molecularly imprinted polymer particles filled capillary electrochromatography. J Liq Chrom Rel Technol 1997; 20(10):1489-506.
17. Rathore AS, Horváth C. Capillary electrochromatography: theories on electroosmotic flow in porous media. J Chromatogr A 1997; 781:185-95.
18. Li D, Remcho VT. Perfusive electroosmotic transport in packed capillary electrochromatography. J Microcol Sep 1997; 9:389-97.
19. Pyell U, Rebescher H, Banholczer A. Influence of sample plug width in capillary electrochromatography. J Chromatogr A 1997; 779:155-63.
20. Euerby MR, Gilligan D, Johnson CM, Bartle KD. Step-gradient capillary electrochromatography. Analyst 1997; 122(10):1087-8.
21. Ding J, Szeliga J, Dipple A, Vouros P. Application of mixed mobile phases and a step gradient method in capillary electrochromatography for the separation of isomeric polycyclic aromatic hydrocarbon-deoxyribonucleoside adduct mixtures prepared in vitro. J Chromatogr A 1997; 781:327-34.
22. Frame LA, Robinson ML, Lough WJ. Simplification of capillary electrochromatography procedures. J Chromatogr A 1998; 798:243-9.
23. Euerby MR, Johnson CM, Cikalo M, Bartle KD. "Short-end injection" rapid analysis capillary electrochromatography. Chromatographia 1998; 47(3/4):135-40.
24. Stead DA, Reid RG, Taylor RB. Capillary electrochromatography of steroids increased sensitivity by on-line concentration and comparison with high-performance liquid chromatography. J Chromatogr A 1998; 798:259-67.