Chronic hypoxia increases staurosporine sensitivity of pulmonary artery smooth muscle to endothelin-1

Pulmonary Pharmacology and Therapeutics

Volumn 11, Issue 2-3, 1998, Pages 159-163

  Bialecki, R A ^a   Fisher, C S ^a   Murdoch, W W ^a   Barthlow, H G ^a  

^a ASTRAZENECA   (United Kingdom)

Author keywords

Endothelin 1; Hypoxia; Protein kinase C; Pulmonary arterial smooth muscle; Staurosporine

Indexed keywords

ENDOTHELIN 1; PROTEIN KINASE C; PROTEIN KINASE C INHIBITOR; STAUROSPORINE;

ANIMAL TISSUE; ARTERY CONSTRICTION; ARTERY MUSCLE; CONFERENCE PAPER; CONTROLLED STUDY; HEART LEFT VENTRICLE; HEART RIGHT VENTRICLE; HEART RIGHT VENTRICLE HYPERTROPHY; HEMATOCRIT; HYPOXIA; MALE; NONHUMAN; PRIORITY JOURNAL; PULMONARY ARTERY; RAT;

EID: 0032056245     PISSN: 10945539     EISSN: None     Source Type: Journal    
DOI: 10.1006/pupt.1998.0131     Document Type: Conference Paper

References (14)

1. 1. Yanagisawa M, Kurihara H, Kimura S, Tomobe Y, Kobayashi M, Mitsui Y, Yazaki Y, Goto K, Masaki T. A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature 1988; 332: 411-415.
2. 2. Bialecki R A, Fisher C S, Murdoch W W, Barthlow H G, Bertelsen D L. Functional comparison of endothelin receptors in human and rat pulmonary artery smooth muscle. Am J Physiol 1997; 272: 211-218.
3. 3. Fukuroda T, Kobayashi M, Ozaki S, Yano M, Miyauchi T, Onizuka M, Sugishita Y, Goto K, Nishikibe M. Endothelin receptor subtypes in human versus rabbit pulmonary arteries. J Appl Physiol 1994; 76: 1976-1982.
4. 4. Hay D W P, Luttmann M A, Hubbard W C, Undem B J. Endothelin receptor subtypes in human and guinea-pig pulmonary tissues. Br J Pharmacol 1993; 110: 1175-1183.
5. 5. Bialecki R A, Fisher C S, Murdoch W W, Barthlow H G, Stow R B, Mallamaci M, Rumsey W. Hypoxie exposure time dependently modulates endothelin-induced contraction of pulmonary artery smooth muscle. Am J Physiol 1998; 274: L552-L559.
6. 6. Takimoto M, Inui T, Okada T, Urade Y. Contraction of smooth muscle by activation of endothelin receptors on autonomic neurons. FEBS Lett 1993; 324: 277-282.
7. 7. Bialecki R A, Tulenko T N. Excess membrane cholesterol alters calcium channels in arterial smooth muscle. Am J Physiol 1989; 257: C306-C314.
8. 8. Danthuluri N R, Brock T A. Endothelin receptor coupling mechanisms in vascular smooth muscle: a role for protein kinase C. J Pharmacol Exp Ther 1990; 254: 393-399.
9. 9. Griendling K K, Tsuda T, Alexander R W. Endothelin stimulates diacylglycerol accumulation and activates protein kinase C in cultured vascular smooth muscle cells. J Biol Chem 1989; 264: 8237-8240.
10. 10. Sokolovsky M. Endothelin receptor subtypes and their role in transmembrane signaling mechanisms. Pharmacol Ther 1995; 68: 435-471.
11. 11. Bialecki R A, Izzo N J, Colucci W S. Endothelin-1 increases intracellular calcium mobilization but not calcium uptake in rabbit vascular smooth muscle cells. Biochem Biophys Res Comm 1989; 164: 474-479.
12. 12. Van Renterghem C, Vigne P, Barhanin J, Schmid-Alliana A, Frelin C, Lazdunski M. Molecular mechanism of action of the vasoconstrictor peptide endothelin. Biochem Biophys Res Comm 1988; 157: 977-985.
13. 13. Kageyama M, Mori T, Yanagisawa T, Taira N. Is staurosporine a specific inhibitor of protein kinase C in intact porcine coronary arteries? J Pharmacol Exp Ther 1991; 259: 1019-1026.
14. + channel-mediated relaxation. Am J Physiol 1992; 7: L88-L94.