Tolerance develops to the antinociceptive and motor impairing effects of ACEA-1416, a NMDA receptor antagonist, in the formalin and rotarod tests in mice

Pharmacological Research

Volumn 37, Issue 4, 1998, Pages 295-302

  Lutfy, K ^a,b   Weber, E ^a,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c Department of Pharmacokinetics and Drug Metabolism   (United States)

Author keywords

Antinociception; Motor activity; NMDA receptor glycine site; Tolerance

Indexed keywords

7 CHLORO 1,4 DIHYDRO 6 METHYL 5 NITRO 2,3 QUINOXALINEDIONE; ACEA 1416; FORMALDEHYDE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG TOLERANCE; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; MOTOR ACTIVITY; MOTOR COORDINATION; MOTOR DYSFUNCTION; MOUSE; NONHUMAN; PRIORITY JOURNAL;

EID: 0032055698     PISSN: 10436618     EISSN: None     Source Type: Journal    
DOI: 10.1006/phrs.1997.0301     Document Type: Article

References (27)

1. 1. Collingridge GL, Lester RAJ. Excitatory amino acid receptors in the vertebrate central nervous system. Pharmacol Rev 1989; 40: 143-210.
2. 2. Dickenson AH. A cure for wind up: NMDA receptor antagonists as potential analgesics. Trends Pharmacol Sci 1990; 11: 307-9.
3. 3. Davies SN, Lodge D. Evidence for involvement of N-methylaspartate receptors in 'wind-up' of class 2 neurons in the dorsal horn of the rat. Brain Res 1987; 424: 402-6.
4. 4. Dickenson AH, Sullivan AF. Evidence for a role of the NMDA receptor in the frequency dependent potentiation of deep rat dorsal horn nociceptive neurones following C fibre stimulation. Neuropharmacology 1987; 26: 1235-8.
5. 5. Dickenson AH, Ayder E. Antagonism at the glycine site on the NMDA receptor reduces spinal nociception in the rat. Neurosci Lett 1991; 121: 263-6.
6. 6. Haley JE, Sullivan AF, Dickenson AH. Evidence for spinal N-methyl-D-aspartate receptor involvement in prolonged chemical nociception in the rat. Brain Res 1990; 518: 218-26.
7. 7. Hunskaar S, Fasmer OB, Hole K. Formalin test in mice, a useful technique for evaluating mild analgesics. J Neurosci Meth 1985; 14: 69-76.
8. 8. Dubbuison D, Dennis SG. The formalin test: a quantitative study of the analgesic effects of morphine, meperidine, and brain stem stimulation in rats and cats. Pain 1977; 4: 161-74.
9. 9. Shibata M, Ohkuba T, Takahashi H, Inoki R. Modified formalin test: characteristic biphasic pain response. Pain 1989; 38: 347-52.
10. 10. Coderre TJ, Melzack R. The contribution of excitatory amino acids to central sensitization and persistent nociception after formalin-induced tissue injury. J Neurosci 1992; 12: 3665-70.
11. 11. Millan MJ, Seguin L. (+)-HA-966, a partial agonist at the glycine site coupled to NMDA receptors, blocks formalin-induced pain in mice. Eur J Pharmacol 1993; 238: 445-7.
12. 12. Millan MJ, Seguin L. Chemically-diverse ligands at the glycine B site coupled to N-methyl-D-aspartate (NMDA) receptors selectively block the late phase of formalin-induced pain in mice. Neurosci Lett 1994; 178: 139-43.
13. 13. Murray CW, Cowan A, Larson AA. Neurokinin and NMDA antagonists (but not a kainic acid antagonist) are antinociceptive in the mouse formalin model. Pain 1991; 44: 179-85.
14. 14. Näsström J, Karlsson U, Post C. Antinociceptive actions of different classes of excitatory amino acid receptor antagonists in mice. Eur J Pharmacol 1992; 212: 21-9.
15. 15. Vaccarino AL, Marek P, Kest B, Weber E, Keana JFW, Liebeskind JC. NMDA receptor antagonists, MK-801 and ACEA-1011, prevent the development of tonic pain following subcutaneous formalin. Brain Res 1993; 615: 331-4.
16. 16. Yamamoto T, Yaksh TL. Comparison of the antinociceptive effects of pre-and posttreatment with intrathecal morphine and MK-801, an NMDA antagonist, on the formalin test in the rat. Anesthesiology 1991; 77: 757-65.
17. 17. Boast CA, Pastor G, Gerhardt SC, Hall NR, Liebman JM. Behavioral tolerance and sensitization to CGS 19755, a competitive N-methyl-D-aspartate receptor antagonist. J Pharmacol Exp Ther 1988; 247: 556-61.
18. 18. Lu Y, France CP, Woods JH. Tolerance to the cataleptic effect of the N-methyl-D-aspartate (NMDA) receptor antagonists in Pigeons: Cross-tolerance between PCP-like compounds and competitive NMDA antagonists. J Pharmacol Exp Ther 1992; 263: 499-504.
19. 19. Nabeshima T, Fukaya H, Yamaguchi K, Ishikawa K, Furukawa H, Kameyama T. Development of tolerance and supersensitivity to phencyclidine in rats after repeated administration of phencyclidine. Eur J Pharmacol 1987; 135: 23-33.
20. 20. Sturgeon RD, Fessler RG, London SF, Meltzer HY. Behavioral effects of chronic phencyclidine administration in rats. Psychopharmacology 1982; 76: 52-56.
21. 21. Wessinger WD. Tolerance to and dependence on MK-801 (Dizocilpine) in rats. Pharmacol Biochem Behav 1994; 49: 1049-56.
22. 22. Ilyin VI, Whittemore ER, Tran M, Shen K-Z, Cai SX, Keana JFW, Weber E, Woodward RM. Pharmacology of ACEA-1416: a potent systemically active NMDA receptor glycine site antagonist. Eur J Pharmacol 1996; 31: 107-14.
23. 23. Carter AJ. Many agents that antagonise the NMDA receptor-channel complex in vivo also cause disturbances of motor coordination. J Pharmacol Exp Ther 1994; 269: 573-80.
24. 24. Rosland JH, Hunskaar S, Hole K. The effect of diazepam on nociception in mice. Pharmacol Toxicol 1987; 61: 111-15.
25. 25. Tallarida RJ, Murray RB. Manual of Pharmacologic Calculations with Computer Programs. Springer-Verlag New York, 1987.
26. 26. Lutfy K, Keana JFW, Weber E. ACEA-1011, a novel NMDA receptor/glycine site antagonist produces antinociception but not tolerance in the formalin test. NIDA Res Monogr 1995; 147: 220-33.
27. 27. Lutfy K, Sadowski B, Marek P, Kown I-S, Keana JFW, Weber E. Differential sensitivity of mice bred for stress-induced analgesia to morphine and ACEA-1011 in the formalin test. Pharmacol Biochem Behav 1996; 54: 495-500.