Synthesis of 4α-(2-propenyl)-5,6-secocholestan 3α-ol, a novel B-ring seco analog of the hypocholesterolemic agent 4α-(2-propenyl)-5α-cholestan- 3α-ol

Steroids

Volumn 63, Issue 4, 1998, Pages 202-207

  Lin, Ho Shen ^a   Rampersaud, Ashraff A ^a   Richett, Michael E ^a   Beavers, Lisa S ^a   McClure, Don B ^a   Gadski, Robert A ^a  

^a ELI LILLY AND COMPANY   (United States)

Author keywords

Oxidative cleavage; Reduction; Reductive alkylation; Secosterol

Indexed keywords

4ALPHA (2 PROPENYL) 5,6 SECOCHOLESTAN 3ALPHA OL; 4ALPHA ALLYL 5ALPHA CHOLESTAN 3ALPHA OL; CHOLEST 4 EN 3 ONE; DRUG ANALOG; HYPOCHOLESTEROLEMIC AGENT; LOW DENSITY LIPOPROTEIN RECEPTOR; SECOSTEROID; STEROID RECEPTOR; UNCLASSIFIED DRUG;

ALKYLATION; ARTICLE; CHEMICAL MODIFICATION; DRUG ACTIVITY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; HAMSTER; ISOLATION PROCEDURE; NONHUMAN; OXIDATION; REDUCTION; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTICHOLESTEREMIC AGENTS; CHO CELLS; CHOLESTANOL; CHOLESTANOLS; CHOLESTENONES; CRICETINAE; GENE EXPRESSION REGULATION; GENES, REPORTER; HYDROXYCHOLESTEROLS; LUCIFERASES; PROMOTER REGIONS (GENETICS); RECEPTORS, LDL; STRUCTURE-ACTIVITY RELATIONSHIP;

CRICETINAE;

EID: 0032055271     PISSN: 0039128X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0039-128X(98)00004-X     Document Type: Article

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