The equid herpesvirus-1 gene 63 is expressed as a leaky late (γ 1) transcript and is nonessential for replication in vitro

Virus Research

Volumn 54, Issue 2, 1998, Pages 189-195

  Purewal, Amarjit S ^a   Iqbal, Javed ^a   Edington, Neil ^a  

^a ROYAL VETERINARY COLLEGE   (United Kingdom)

Author keywords

Equid herpes virus 1; Gene 63 mutant virus; Immediate early gene

Indexed keywords

ARTICLE; GENE EXPRESSION; HERPES SIMPLEX VIRUS 1; IMMEDIATE EARLY GENE; NONHUMAN; PRIORITY JOURNAL; VIROGENESIS; VIRUS GENE; VIRUS MUTANT; VIRUS REPLICATION;

ANIMALS; CELL LINE; CRICETINAE; GENE EXPRESSION REGULATION, VIRAL; GENES, VIRAL; HERPESVIRUS 1, EQUID; VIRUS REPLICATION;

ANIMALIA; EQUIDAE; EQUINE HERPESVIRUS 1; FELIS CATUS; HERPES; HERPES VIRUS 1; HERPESVIRIDAE; HERPESVIRUS 1;

EID: 0032052685     PISSN: 01681702     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-1702(98)00005-7     Document Type: Article

References (27)

1. Allen G.P., Bryans J.T. Molecular epizootiology, pathogenesis and prophylaxis of equine herpesvirus-1 infections. Prog. Vet Microbiol. Immunol. 2:1986;78-144.
2. Bowles D.E., Holden V.R., Zhao Y., O'Callaghan D.J. The ICP0 protein of equine herpesvirus 1 is an early protein that independently transactivates expression of all classes of viral promoters. J. Virol. 71:1997;4904-4914.
3. Cai W., Schaffer P.A. Herpes simplex virus type 1 ICP0 regulates expression of immediate-early, early and late genes in productively infected cells. J. Virol. 66:1992;2904-2915.
4. Campbell M.E., Palfreyman J.W., Preston C.M. Identification of herpes simplex virus DNA sequences which encode a trans-acting polypeptide responsible for stimulation of immediate early transcription. J. Mol. Biol. 180:1984;1-19.
5. Chesters P.M., Allsop R., Purewal A., Edington N. Detection of latency associated transcripts of equid herpesvirus 1 in equine leukocytes but not in trigeminal ganglia. J. Virol. 71:1997;3437-3443.
6. Chomczynski P., Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroforrn extraction. Anal. Biochem. 162:1987;156-159.
7. Everett R.D. The regulation of transcription of viral and cellular genes by herpesvirus immediate early gene products. Anti-Cancer Res. 7:1987;589-604.
8. Everett R.D., Orr A., Elliott M. High level expression and purification of herpes simplex virus type 1 immediate early polypeptide Vmw110. Nucleic Acids Res. 19:1991;6155-6161.
9. Everett, R.D., Preston, C.M., Stow, N.D., 199l. Functional and genetic analysis of the role of Vmw110 in herpes simplex virus replication. In: Wagner, E.K. (Ed.), Herpes Virus Transcription and its Regulation. CRC Press, Boca Raton, FL.
10. 4 motif of an α herpes protein family. J. Mol. Biol. 234:1993;1038-1047.
11. Everett R., Orr A., Elliott M. The equine herpesvirus 1 gene 63 RING finger protein partially complements Vmw110, its herpes simplex virus type 1 counterpart. J. Gen. Virol. 76:1995;2369-2374.
12. Edington N. Latency of Equine Herpesviruses, VIth International Conference of Equine Infectious Diseases. 1991;195-200 Cambridge, UK.
13. Grundy F.J., Baumann R.P., O'Callaghan D.J. DNA sequence and comparative analysis of the equine herpesvirus type 1 immediate early gene. Virology. 172:1989;223-236.
14. Higuchi R. Recombinant PCR. Innis M.A., Gelfand D.H., Sninsky J.J., White T.J. PCR Protocols. 1990;177-183 Academic Press, San Diego.
15. McGeoch D.J., Barnett B.C., MacLean C.A. Emerging functions of α herpesvirus genes. Semin. Virol. 4:1993;125-134.
16. Meredith M., Orr A., Elliott M., Everett R.D. Separation of sequence requirements for HSV-1 Vmw110 multimerisation and interaction with a 135 kDa cellular protein. Virology. 209:1995;174-187.
17. Patel J.R., Edington N. The pathogenicity in mice of respiratory, abortion and paresis isolates of equine herpesvirus-1. Vet Microbiol. 8:1983;301-305.
18. Purewal A.S., Smallwood A.V., Kaushal A, Adegboye D., Edington N. Identification and control of the cis-acting elements of the immediate-early gene of equid herpesvirus type 1. J. Gen. Virol. 73:1992;513-519.
19. Purewal A.S., Smallwood A.V., Allsopp R., Welch H.M., Edington N. Cross hybridization of equid herpesvirus-2 (EHV-2) and herpes simplex virus-1 (HSV-1) genes to equid herpesvirus-1 (EHV-1). Vet Microbiol. 35:1993;1-10.
20. Purewal A.S., Allsopp R., Riggio M., Telford E.A.R., Azam S., Davison A.J., Edington N. Equid herpesviruses 1 and 4 encode functional homologs of the herpes simplex virus type 1 transactivator protein, VP16. Virology. 198:1994;385-389.
21. Rixon F.J., Mclauchlan J. Insertion of DNA sequences at a unique restriction enzyme site engineered for vector purposes into the genome of herpes simplex virus type 1. J. Gen. Virol. 71:1990;2931-2939.
22. Sadowski I., Ma J., Triezenberg S., Ptashne M. GAL4-VP16 is an unusually potent transcriptional activator. Nature. 335:1988;563-564.
23. Sanger F., Nicklen S., Coulsen A.R. DNA sequencing with chain-terminating inhibitors. PNAS USA. 74:1977;5463-5467.
24. Smith R.H., Zhao Y., O'Callaghan D.J. The equine herpesvirus 1 (EHV-1) UL3 gene, an ICP27 homolog, is necessary for full activation of gene expression directed by an EHV-1 late promoter. J. Virol. 67:1993;1105-1109.
25. Stow N.D., Wilkie N.M. An improved technique for obtaining enhanced infectivity with herpes simplex virus type 1 DNA. J. Gen. Virol. 33:1976;447-458.
26. Telford E.A.R., Watson M.S., McBride K., Davison A.J. The DNA sequence of equine herpesvirus-1. Virology. 189:1992;304-316.
27. Welch H.M., Bridges C.G., Lyon A.M., Griffiths L., Edington N. Latent equid herpesviruses 1 and 4: Detection and distinction using the polymerase chain reaction and co cultivation from lymphoid tissues. J. Gen. Virol. 73:1992;261-268.