Effect of modifying O2 diffusivity and delivery on glomerular and tubular function in hypoxic perfused kidney

American Journal of Physiology - Renal Physiology

Volumn 274, Issue 4 43-4, 1998, Pages

  Baines, A D ^a   Adamson, G ^b   Wojciechowski, P ^b   Pliura, D ^b   Ho, P ^b   Kluger, R ^b  

^a UNIVERSITY OF TORONTO   (Canada)

^b NONE

Author keywords

Blood substitute; Facilitated diffusion; Glomerular filtration rate; Hemoglobin; Oxygen affinity; Renal energy consumption; Sodium reabsorption

Indexed keywords

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; GLOMERULUS; GLOMERULUS FILTRATION RATE; GLUCOSE TRANSPORT; HYPOXIA; ISOLATED KIDNEY; KIDNEY FUNCTION; KIDNEY INJURY; KIDNEY PERFUSION; KIDNEY TUBULE; MALE; NONHUMAN; OXYGEN CONSUMPTION; OXYGEN TRANSPORT; PHOSPHATE EXCRETION; PRIORITY JOURNAL; RAT; SODIUM ABSORPTION; ANIMAL; ANOXIA; BIOAVAILABILITY; BLOOD; DIFFUSION; METABOLISM; OSMOLARITY; PATHOPHYSIOLOGY; PERFUSION; PHYSIOLOGY; WISTAR RAT;

HEMOGLOBIN; OXYGEN;

ANIMALS; ANOXIA; BIOLOGICAL AVAILABILITY; DIFFUSION; GLOMERULAR FILTRATION RATE; HEMOGLOBINS; KIDNEY GLOMERULUS; KIDNEY TUBULES; MALE; OSMOLAR CONCENTRATION; OXYGEN; PERFUSION; RATS; RATS, WISTAR;

EID: 0032040169     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.1998.274.4.f744     Document Type: Article

References (20)

1. Baines, A. D., B. Christoff, D. Wicks, D. Wiffen, and D. Pliura. Cross-linked hemoglobin increases fractional reabsorption and GFR in hypoxic isolated perfused rat kidneys. Am. J. Physiol. 269 (Renal Fluid Electrolyte Physiol. 38): F628-F636, 1995.
2. Baines, A. D., R. Drangova, and C. Hatcher. Dopamine production by isolated glomeruli and tubules from rat kidneys. Can. J. Physiol. Pharmacol. 63: 155-158, 1985.
3. Baines, A. D., P. Ho, and H. James. Metabolic control of renal vascular resistance and glomerulotubular balance. Kidney Int. 27: 848-854, 1985.
4. Brezis, M., Y. Agmon, and F. H. Epstein. Determinants of intrarenal oxygenation. I. Effects of diuretics. Am. J. Physiol. 267 (Renal Fluid Electrolyte Physiol. 36): F1059-F1062, 1994.
5. Brezis, M., S. N. Heyman, and F. H. Epstein. Determinants of intrarenal oxygenation. II. Hemodynamic effects. Am. J. Physiol. 267 (Renal Fluid Electrolyte Physiol. 36): F1063-F1068, 1994.
6. Brezis, M., S. Rosen, K. Spokes, P. Silva, and F. H. Epstein. Transport-dependent anoxic cell injury in the isolated perfused rat kidney. Am. J. Pathol. 116: 327-341, 1984.
7. Bryant, S. C., and R. M. Navari. Effect of plasma proteins on oxygen diffusion in the pumonary capillaries. Microvasc. Res. 7: 120-130, 1974.
8. Cussler, E. L. Diffusion. Cambridge, UK: Cambridge University Press, 1984.
9. Darling, R. C., and F. J. W. Roughton. The effect of methemoglobin on the equilibrium between oxygen and hemoglobin. Am. J. Physiol. 137: 56-68, 1942.
10. Endre, Z. H., P. J. Ratcliffe, J. D. Tange, D. J. P. Ferguson, G. K. Radda, and J. G. G. Ledingham. Erythrocytes alter the pattern of renal hypoxic injury: predominance of proximal tubular injury with moderate hypoxia. Clin. Sci. (Colch.) 76: 19-29, 1989.
11. Gullans, S. R., P. C. Brazy, S. P. Soltoff, V. W. Dennis, and L. Mandel. Metabolic inhibitors: effects on metabolism and transport in the proximal tubule. Am. J. Physiol. 243 (Renal Fluid Electrolyte Physiol. 12): F133-F140, 1982.
12. Gullans, S. R., and L. J. Mandel. Coupling of energy to transport in proximal and distal nephron. In: The Kidney: Physiology and Pathophysiology, edited by D. W. Seldin and G. Giebisch. New York: Raven, 1992, p. 1291-1337.
13. Hashimoto, M., R. Hata, T. Shiga, A. Isomoto, and M. Uozumi. Facilitated transport of oxygen through hemoglobin solutions. In: Oxygen Transport to Tissue (12th ed.), edited by J. Piiper. New York: Plenum, 1990, p. 181-190.
14. 2 delivery in dog muscle in situ. J. Appl. Physiol. 70: 2656-2662, 1991.
15. Kluger, R., and Y. Song. Changing a protein into a generalized acylating reagent. Reaction of nucleophiles 3,5-dibromosalicyl trimesyl-[(Lysβ82)-(Lysβ82)]-hemoglobin. J. Org. Chem. 59: 733-736, 1994.
16. Kluger, R., J. Wodzinska, R. T. Jones, C. Head, T. S. Fujita, and D. T. Shih. Three point cross-linking: potential red cell substitutes from the reaction of trimesoyl tris(methyl phosphate) with hemoglobin. Biochemistry 31: 7551-7559, 1992.
17. Nesbitt, T., J. K. Byun, and M. K. Drezner. Normal phosphate transport in cells from the S2 and S3 segments of Hyp-mouse proximal renal tubules. Endocrinology 137: 943-948, 1996.
18. Schumacher, M. A., M. M. Dixon, R. Kluger, R. T. Jones, and R. G. Brennan. Allosteric transition intermediates modelled by crosslinked haemoglobins. Nature 375: 494-499, 1995.
19. Silverman, M., and R. J. Turner. Glucose transport in the renal proximal tubule. In: Handbook of Physiology. Renal Physiology, Bethesda, MD: Am. Physiol. Soc., 1992, sect. 8, vol. II, chapt. 43, p. 2017-2038.
20. 2 delivery. Artif. Cells Blood Substit. Immobil. Biotechnol. 22: 763-768, 1994.