Nuclear overexpression of bcl-2 oncoprotein during the progression of human stomach cancer

Journal of Korean Medical Science

Volumn 13, Issue 2, 1998, Pages 153-158

  Lee, Seung Sook ^a   Cho, Kyung Ja ^a   Hong, Seok Il ^a   Myoung, Nan Kyoung ^b   Jang, Ja June ^b  

^a Korea Cancer Center Hospital   (South Korea)

^b Seoul National University   (South Korea)

Author keywords

Gastric adenoma; Genes, bcl 2; Immunohistochemistry; Nuclear expression; Stomach neoplasms

Indexed keywords

PROTEIN BCL 2;

ADENOMA; ARTICLE; BIOSYNTHESIS; CARCINOMA; CELL NUCLEUS; DISEASE COURSE; HUMAN; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; STOMACH TUMOR;

ADENOMA; CARCINOMA; CELL NUCLEUS; DISEASE PROGRESSION; HUMANS; PROTO-ONCOGENE PROTEINS C-BCL-2; STOMACH NEOPLASMS;

EID: 0032037896     PISSN: 10118934     EISSN: None     Source Type: Journal    
DOI: 10.3346/jkms.1998.13.2.153     Document Type: Article

References (25)

1. Hockenbery D, Nunez G, Milliman G, Schreiber RD, Korsmeyer SJ. Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death. Nature 1990; 348: 334-6.
2. Korsmeyer SJ. Bcl-2 initiates a new category of oncogene: regulators of cell death Blood 1992; 80: 879-86.
3. Tsujimoto Y, Cossman J, Jaffe E, Croce C. Involvement of the bcl-2 gene in human follicular lymphoma. Science 1985; 228: 1440-3.
4. Gaulard P, d'Agay M-F, Peuchmaur M, Brousse N, Gisselbrecht C, Solal-Celigny P, Diebold J, Mason DY. Expression of the bcl-2 gene product in follicular lymphoma. Am J Pathol 1992; 140: 1089-95.
5. Pezzella F, Tse AGD, Cordell JL, Pulford KAF, Gatter KC, Mason DY. Expression of the bcl-2 oncogene protein is not specific for the 14;18 chromosomal translocation. Am J Pathol 1990; 137: 225-32.
6. Kondo E, Yoshino T, Yamadori I, Matsuo Y, Kawasaki N, Minowada J, Akagi T. Expression of Bcl-2 protein and Fas antigen in non-Hodgkin's lymphomas. Am J Pathol 1994; 145: 330-7.
7. Nakamura S, Akazawa K, Kinukawa N, Kinukawa N, Yao T, Tsuneyoshi M. Inverse correlation between the expression of bcl-2 and p53 proteins in primary gastric lymphoma. Hum Pathol 1996; 27: 225-33.
8. Hockenbery DM, Zutter M, Hickey W, Nahm M, Korsmeyer SJ. Bcl-2 protein is topographically restricted in tissues characterized by apoptotic cell death. Proc Natl Acad Sci USA 1991; 88: 6961-5.
9. Bosari S, Moneghini L, Graziani D, et al. Bcl-2 oncoprotein in colorectal hyperplastic polyps, adenomas, and adenocarcinomas. Hum Pathol 1995; 26: 534-40.
10. Pezzella F, Turley H, Kuzu I, aaatungekar MF, Dunnill MS, Pierce Crish, et al. Bcl-2 protein in non-small cell lung carcinoma. N Engl J Med 1993; 329: 690-4.
11. Doglioni C, Dei Tos AP, Laurino L, Chiarelli C, Barbareschi M, Viale G. The prevalence of Bcl-2 immunoreactivity in breast carcinomas and its clinicopathological correlates, with particular reference to oestrogen receptor status. Virchows Archiv 1994; 424: 47-51.
12. LeBrun DP, Warnke RA, Cleary ML. Expression of bcl-2 in fetal tissues suggests a role in morphogenesis. Am J Pathol 1993; 142: 743-53.
13. Willingham MC, Bhalla K. Transient mitotic phase localization of bcl-2 oncoprotein in human carcinoma cells and its possible role in prevention of apoptosis. J Histochem Cytochem 1994; 42: 441-50.
14. Gown AM, deWever N, Battifora H. Microwave-based antigenic unmasking. Appl Immunohistochem 1993; 1: 256-66.
15. Krajowski S, Taraka S, Takayama S, Schibler MJ, Fenton W, Reed JC. Investigation of the subcellular distribution of the bcl-2 oncoprotein: Residence in the nuclear envelope, endoplasmlc reticulum, and outer mitochondrial membranes. Cancer Res 1993; 53: 4701-14.
16. Bronner MP, Culin C, Reed JC, Furth EE. The bcl-2 proto-oncogene and the gastrointestinal epithelial tumor progression model. Am J Pathol 1995; 146: 20-6.
17. Lauren P. The two histological main types of gastric carcinoma: diffuse and so-called intestinal type carcinomas- an attempt at a histoclinical classification. Acta Pathol Microbiol Scand 1965; 64: 31-49.
18. Lawers GY, Scott GV, Hendricks J. Immunohistochemical evidence of aberrant bcl-2 protein expression in gastric epithelial dysplasia. Cancer 1994; 73: 2900-4.
19. Lawers GY, Scott GV, Karpeh MS. Immunohistochemical evaluation of bcl-2 protein expression in gastric adenocarcinomas. Cancer 1995; 75: 2209-13.
20. Oguey D, Marti U, Reichen J. Epidermal growth factor receptor in chronic bile duct obstructed rats: implications for maintenance of hepatocellular mass. Eur J Cell Biol 1992; 59: 187-95.
21. Chen-Levy Z, Nourse J, Cleary ML. The bcl-2 candidate proto-oncogene product is a 24-kilodalton integral-membrane protein highly expressed in lymphoid cell lines and lymphomas carrying the t (14;18) translocation. Mol Cell Biol 1989; 9: 701-10.
22. Monaghan P, Robertson D, Andrew T, Amos S, Dyer MJS, Mason DY, Greaves MF. Ultrastructural localization of bcl-2 protein. J Histochem Cytochem 1992; 40: 1819-25.
23. Jacobson MD, Burne JF, King MP, Kiyashita T, Reed JC, Raff MC. Bcl-2 blocks apoptosis in cells lacking mitochondrial DNA. Nature (London) 1993; 361: 365-8.
24. Alnemri ES, Robertson NM, Fernandas TF, Croce CM, Litwack G. Overexpressed full-length human BCL-2 extends survival of baculovirus-infected SF9 insect cells. Proc Natl Acad Sci USA 1992; 89: 7295-9.
25. Ayhan A, Yasui W, Yokozaki H, Seto M, Ueda R, Tahara E. Loss of heterozygosity at the bcl-2 gene locus and expression of bcl-2 in human gastric and colorectal carcinomas. Jpn J Cancer Res 1994; 85: 584-91.