The effect of the ET(A) receptor antagonist (CI-1020) in rats with established hypoxic pulmonary hypertension

Pulmonary Pharmacology and Therapeutics

Volumn 11, Issue 2-3, 1998, Pages 173-176

  Sheedy, W ^b   Haleen, S ^a   Morice, A H ^b  

^a PFIZER INC   (United States)

^b UNIVERSITY OF HULL   (United Kingdom)

Author keywords

CI 1020; Endothelin A receptor; Isolated perfused lung; Pulmonary hypertension; Vascular remodelling

Indexed keywords

4 (4 METHOXYPHENYL) 2 (3,4 METHYLENEDIOXYPHENYL) 4 OXO 3 (3,4,5 TRIMETHOXYBENZYL) 2 BUTENOIC ACID; ENDOTHELIN A RECEPTOR ANTAGONIST; UNCLASSIFIED DRUG; 1,3 DIOXOLANE DERIVATIVE; ENDOTHELIN RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; BODY WEIGHT; CONFERENCE PAPER; CONTROLLED STUDY; HEART LEFT VENTRICLE; HEART RIGHT VENTRICLE; HEART VENTRICLE SEPTUM; HEART WEIGHT; HYPOXIC LUNG VASOCONSTRICTION; ISOLATED LUNG; LUNG ARTERY PRESSURE; LUNG VASCULAR RESISTANCE; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; PULMONARY HYPERTENSION; RAT; ANIMAL; ANOXIA; ARTICLE; DISEASE MODEL; DRUG ANTAGONISM; PATHOPHYSIOLOGY; PHYSIOLOGY; PULMONARY ARTERY; PULMONARY VEIN; VASCULAR RESISTANCE; WISTAR RAT;

ADMINISTRATION, ORAL; ANIMALS; ANOXIA; DIOXOLES; DISEASE MODELS, ANIMAL; HYPERTENSION, PULMONARY; MALE; PULMONARY ARTERY; PULMONARY VEINS; RATS; RATS, WISTAR; RECEPTORS, ENDOTHELIN; VASCULAR RESISTANCE;

EID: 0032035399     PISSN: 10945539     EISSN: None     Source Type: Journal    
DOI: 10.1006/pupt.1998.0132     Document Type: Conference Paper

References (18)

1. 1. DeMey J G, Vanhoutte P M. Anoxia and endothelium-dependent reactivity of the canine femoral artery. J Physiol 1983; 335: 65-74.
2. 2. Yanagisawa M, Kurihara H, Kimura S. A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature 1988; 332: 411-415.
3. 3. Shirakami G, Nakao K, Saito Y, Magaibuchi T, Jougaski M, Mukoyama M, et al. Acute pulmonary alveolar hypoxia increases lung and plasma endothelium-1 levels in conscious rats. Life Sci 1991; 48: 969-976.
4. 4. Goerre S, Wenk M, Bartsch P, Luscher T F, Nirroomard F, Hohenhaus E, Oelz O, Reinhart W H. Endothelin-1 in pulmonary hypertension associated with high altitude exposure. N Engl J Med 1995; 90: 359-364.
5. 5. Giaid A, Yanagisawa M, Langleben D, Michel R P, Levy R, Shennib H, Kimura S, Masaki T, Duguid W P, Stewart D J. Expression of endothelin-1 in the lungs of patients with pulmonary hypertension. N Engl J Med 1993; 328: 1732-1739.
6. 6. Stewart J D, Levy R D, Cernacek P, Langeleben D. Increased plasma endothelin-1 in pulmonary hypertension: marker or mediator of disease? Ann Intern Med 1991; 114: 464-469.
7. 7. Koseki C, Imai M, Hirata Y, Yanagisawa M, Masaki T. Binding sites for endothelin-1 in rat tissues: an autoradiographic study. J Cardiovasc Pharmacol 1989; 13: S153-S154.
8. 8. Hay W P, Luttman M A, Hubbard W C, Undem B J. Endothelin receptor subtypes in human and guinea-pig pulmonary arteries. Br J Pharmacol 1993; 110: 1175-1783.
9. 9. Komuro I, Kurimara H, Sugiyama T, Takaku F, Yazaki Y Endothelin stimulates c-fos and c-myc expression and proliferation of vascular smooth muscle cells. FEBS Letts 1988; 238: 249-252.
10. 10. Patt W C, Edmunds J J, Repine J T, Berryman K A, Reisdorph B R, Lee C, Plummer M S, Shahripour A, Haleen S J, Keiser J A, Flynn M A, Welch K M, Reynolds E E, Rubin R, Tobias B, Hallak H, Doherty A M. Structure-activity relationships in a series of orally active-hydroxy butenolide endothelin antagonists. J Med Chem 1997; 40: 1063-1074.
11. 11. Sheedy W, Thompson J S, Morice A H. A comparison of pathophysiological changes during hypobaric and normobaric hypoxia in rats. Respiration 1996; 63: 217-222.
12. 12. Emery C J, Bee D, Barer G R. Mechanical properties of vessels in isolated perfused lungs of chronically hypoxic rats. Clin Sci 1981; 61: 569-580.
13. B receptors. J Pharmac Exp Ther 1997; 280: 1102-1108.
14. 14. Li H, Chen S, Chen Y, Meng Q C, Durand J, Oparil S, Elton T S. Enhanced endothelin-1 and endothelin receptor gene expression in chronic hypoxia. J Appl Physiol 1994; 77(3): 1451-1459.
15. A receptor antagonist prevents and reverses chronic hypoxia-induced pulmonary hypertension in rat. Am J Physiol 1995; 269: L690-L697.
16. 16. Oparil S, Chen S-J, Meng Q C, Elton T S, Yano M, Chen Y-F. Endothelin-A receptor antagonist prevents acute hypoxia-induced pulmonary hypertension in the rat. Am J Physiol Lung Cell Mol Physiol 1995; 268: L95-L100.
17. A-receptor antagonist, attenuates hypoxic pulmonary hypertension in rats. Am J Physiol Heart Circ Physiol 1994; 266: H1327-H1331.
18. 18. Voelkel N F. Mechanisms of hypoxic pulmonary vasoconstriction. Am Rev Respir Dis 1986; 133: 1186-1195.