99mTc-MIBI, 99mTc-tetrofosmin and 99mTc-Q12 in vitro and in vivo

Nuclear Medicine and Biology

Volumn 25, Issue 3, 1998, Pages 233-240

  Bernard, Bert F ^a   Krenning, Eric P ^a   Breeman, Wout A P ^a   Ensing, Geert ^b   Benjamins, Harry ^b   Bakker, Willem H ^a   Visser, Theo J ^a   De Jong, Marion ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b Mallinckrodt Medical   (Netherlands)

Author keywords

99mTc Q12; 99mTc MIBI; 99mTc tetrofosmin; Biodistribution; Tumor; Uptake

Indexed keywords

METHOXY ISOBUTYL ISONITRILE TECHNETIUM TC 99M; Q 12 TC 99M; TECHNETIUM 99M; TECHNETIUM DERIVATIVE; TETROFOSMIN TC 99M; UNCLASSIFIED DRUG; FURAN DERIVATIVE; ORGANOPHOSPHORUS COMPOUND; RADIOPHARMACEUTICAL AGENT; TECHNETIUM COMPLEX; TECHNETIUM TC 99M 1,2 BIS(BIS(2 ETHOXYETHYL)PHOSPHINO)ETHANE; TECHNETIUM TC 99M 1,2-BIS(BIS(2-ETHOXYETHYL)PHOSPHINO)ETHANE; TECHNETIUM TC 99M Q12;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BREAST TUMOR; CANCER CELL CULTURE; CELL MEMBRANE TRANSPORT; DRUG DISTRIBUTION; DRUG TISSUE LEVEL; DRUG TUMOR LEVEL; DRUG UPTAKE; FEMALE; HEART; MALE; MITOCHONDRION; NONHUMAN; RAT; ANIMAL; CELL CULTURE; CELL MEMBRANE; COMPARATIVE STUDY; HEART MUSCLE; HUMAN; KINETICS; METABOLISM; PHYSIOLOGY; TISSUE DISTRIBUTION; TRANSPORT AT THE CELLULAR LEVEL; WISTAR RAT;

ANIMALS; BIOLOGICAL TRANSPORT; BREAST NEOPLASMS; CELL MEMBRANE; FEMALE; FURANS; HUMANS; KINETICS; MALE; MITOCHONDRIA; MYOCARDIUM; ORGANOPHOSPHORUS COMPOUNDS; ORGANOTECHNETIUM COMPOUNDS; RADIOPHARMACEUTICALS; RATS; RATS, WISTAR; TECHNETIUM TC 99M SESTAMIBI; TISSUE DISTRIBUTION; TUMOR CELLS, CULTURED;

EID: 0032034248     PISSN: 09698051     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0969-8051(97)00201-1     Document Type: Article

References (23)

1. 1. Aigner R. M., Fueger G. F. and Wolf G. (1997) Parathyroid scintigraphy: First experiences with technetium(III)-99m-Q12. Eur. J. Nucl. Med. 24, 326-329.
2. 2. Arbab A. S., Koizumi K., Toyama K. and Arazki T. (1996) Uptake of technetium-99m-tetrofosmin, technetium-99m-MIBI and thallium-201 in tumor cell lines. J. Nucl. Med. 37, 1551-1556.
3. 3. Bagni B., Pinna L., Tamarozzi R., Cattaruzzi E., Marzola M. C., Bagni I., Ceruti S., Valentini A., Zanasi A. and Mavilla L. (1995) SPECT imaging of intracranial tumors with technetium-99m-sestamibi. Nucl. Med. Commun. 16, 258-264.
4. 4. Ballinger J. R., Banneman J., Boxen I., Firby P., Hartman N. G. and Moore M. J. (1996) Tc-99m-tetrofosmin as a substrate for P-glycoprotein: In vitro studies in multidrug-resistant breast tumor cells. J. Nucl. Med. 37, 1578-1582.
5. 99mTc-Mibi: A comparative study with mammography and ultrasonography. Nucl. Med. Commun. 15, 604-612.
6. 6. Coakley A. J. and Kettle A. (1989) Technetium-99m-sestamibi: A new agent for parathyroid imaging. Nucl. Med. Commun. 10, 791-794.
7. 7. Crankshaw C. L., Marmion M., Burleigh B. D., Deutsch E. and Piwnica-Worms D. (1995) Non-reducible mixed ligand Tc(III)cations (Q-complexes) are recognized as transport substrates by the human multidrug resistance (MDR) P-glycoprotein. J. Nucl. Med. 36, 130P.
8. 99mTc-Q12 into human breast cancer cell lines. Eur. J. Nucl. Med. 23, 1361-1366.
9. 9. De Jong M., Visser T. J., Bernard H. F., Docter R., Vos R. A., Hennemann G. and Krenning E. P. (1993) Transport and metabolism of iodothyronines in cultured human hepatocytes. J. Clin. Endocrinol. Metab. 77, 139-143.
10. 10. Jacobsson H., Wallin G., Werner S. and Larson S. A. (1994) Technetium-99m methoxyisobutylisonitrile localizes an ectopic ACTH-producing tumor: Case report and review of the literature. Eur. J. Nucl. Med. 21, 582-586.
11. 11. Jones A. G., Abrams M. G., Davison A., Brodach J. W., Toothaker A. K., Adelstein S. J. and Kassis A. I. (1984) Biological studies of a new class of technetium: The hexakis (alkylisontrile) technetium (II) cations. Int. J. Nucl. Biol. 11, 225-234.
12. 12. Kao C. H., Wang S. J. and Liu T. J. (1994) The use of technetium-99m methoxyisobutylisonitrile breast scintigraphy to evaluate palpable breast masses. Eur. J. Nucl. Med. 21, 432-436.
13. 13. Kelly J. D., Forster A. M., Higley B., Archer C. M., Booker F. S., Canning L. R., Chiu K. W., Edwards B., Gill H. K., McPartlin M., Nagle K. R., Latham I. A., Pickett R. D., Storey A. E. and Webbon P. M. (1993) Technetium-99m-tetrofosmin as a new radiopharmaceutical for myocardial perfusion imaging. J. Nucl. Med. 34, 222-227.
14. 14. Mansi L., Rambaldi P. F., Marino G., Pecori B. and Del Vecchio E. (1995) Tc-99m tetrofosmin uptake in breast tumors. J. Nucl. Med. 36, 83P.
15. 15. Müller S., Guth-Tougelides B. and Creutzig H. (1987) Imaging of malignant tumors with Tc-99m-MIBI. Eur. J. Nucl. Med. 28, 562.
16. 16. Müller S. P., Reiners C., Paas M., Guth-Tougelides B., Budach V., Konietzko N. and Alberti W. (1989) Tc-99m-MIBI and Tl-201 uptake in bronchial carcinoma. Eur. J. Nucl. Med. 30, 485.
17. 17. Piwnica-Worms D. and Holman B. L. (1990) Noncardiac applications of hexakis-(alkylisonitril)-technetium-99m complexes. J. Nucl. Med. 31, 1166-1167.
18. 18. Piwnica-Worms D., Chiu M. L., Budding M., Kronauge J. F., Kramer R. A. and Croop J. M. (1993) Functional imaging of multidrug-resistant P-glycoprotein with an organotechnetium complex. Cancer Res. 53, 977-984.
19. 19. Reed P. W. (1979) Ionophores. Methods Enzymol. 55, 435-454.
20. 20. Rossetti C., Vanoli G., Paganelli G., Kwiatkowsky M., Zito F., Colombo F., Bonino C., Carpinelli A., Casati R., Deutsch K., Marmion M., Woulfe S. R., Lunghi F., Deutsch E. and Fazio F. (1994) Human biodistribution, dosimetry and clinical use of technetium (III)-99m-Q12. J. Nucl. Med. 35, 1571-1580.
21. 21. Rotenberg H. and Scarpa A. (1974) Calcium uptake and membrane potential in mitochondria. Biochemistry 13, 4811-4817.
22. 22. Van Heugten H. A. A., Bezstarosti K. and Lamers J. M. J. (1994) Endothelin-1 and phenylephrine-induced activation of the phosphoinositide cycle increases cell injury of cultured cardiomyocytes exposed to hypoxia/reoxygenation. J. Mol. Cell. Cardiol. 26, 1513-1524.
23. 23. Wackers F. J. T., Berman D. S., Maddahi J., Watson D. D., Beller G. A., Strauss H. W., Boucher C. A., Picard M., Holman B. L., Fridrich R., Inglese F., Delaloye B., Bischof-Delaloye A., Camin L. and McKusick K. (1989) Technetium 99m hexakis 2-methoxyisobutyl isonitrile: Human distribution, dosimetry, safety and preliminary comparison to thallium 201 for myocardial perfusion imaging. J. Nucl. Med. 30, 301-311.