Taxol can induce phosphorylation of BCL-2 in multiple myeloma cells and potentiate dexamethasone-induced apoptosis

Leukemia Research

Volumn 22, Issue 3, 1998, Pages 275-286

  Kroning, Relef ^a   Lichtenstein, Alan ^a  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Apoptosis; BCL 2; Dexamethasone; Multiple myeloma; Synergistic cytotoxicity; Taxol

Indexed keywords

ANTINEOPLASTIC AGENT; DEXAMETHASONE; GLUCOCORTICOID; PACLITAXEL; PROTEIN BCL 2;

APOPTOSIS; ARTICLE; HUMAN; HUMAN CELL; MYELOMA CELL; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; TUMOR CELL LINE;

ANTIBIOTICS, ANTINEOPLASTIC; ANTINEOPLASTIC AGENTS, HORMONAL; ANTINEOPLASTIC AGENTS, PHYTOGENIC; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; APOPTOSIS; BENZOQUINONES; DEXAMETHASONE; DRUG INTERACTIONS; DRUG SYNERGISM; HUMANS; LACTAMS, MACROCYCLIC; MULTIPLE MYELOMA; PACLITAXEL; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-BCL-2; QUINONES; TUMOR CELLS, CULTURED;

EID: 0032033447     PISSN: 01452126     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0145-2126(97)00170-7     Document Type: Article

References (28)

1. 1. Drewinko, B., Alexanian, R., Boyer, H., Barlogie, B. and Rubinow, S. I., The growth fraction of human myeloma cells. Blood, 1981, 57, 333.
2. 2. Mariano, M., Moretti, L., Donelli, A., Grantini, M., Montagnani, G., Di Prisco, A. U., Torelli, G., Torelli, U. and Narni, F., BCL-2 gene expression in hematopoietic cell differentiation. Blood, 1992, 80, 768.
3. 3. Pettersson, M., Jernberg-Wiklund, H., Larsson, L. G., Sundstrom, C., Givol, I., Tsujimoto, Y. and Nilsson, K., Expression of the BCL-2 gene in human multiple myeloma cell lines and normal plasma cells. Blood, 1992, 79, 495.
4. 4. Dune, B.G.M., Mason, D.Y., Giles, F., Vela, E., Knight, E., Wolff, I., Foadi, M. and Samson, D., Expression of the BCL-2 oncogene protein in multiple myeloma. Blood, 1990, 76, 347a (abstract).
5. 5. Tu, Y., Xu, F.-H., Liu, J., Vescio, R., Berenson, J., Fady, C. and Lichtenstein, A., Upregulated expression of BCL-2 in multiple myeloma cells induced by exposure to doxorubicin, etoposide, and hydrogen peroxide. Blood, 1996, 88, 1805.
6. 6. Schwarze, M. M. K. and Hawley, R. G., Prevention of myeloma cell apoptosis by ectopic BCL-expression or IL-6 mediated upregulation of BCL-X-L. Cancer Research, 1995, 55, 2262.
7. 7. Siegel, D.S., Koury, J., Terry, J.A., Barlogie, B., Epstein, J. and Feinman, R., Molecular mechanisms of resistance in drug-induced apoptosis of myeloma cells. Blood, 1996, 88, 641a (abstract).
8. 8. Haldar, S., Jena, N. and Croce, C. M., Inactivation of BCL-2 by phosphorylation. Proc. Natl. Acad. Sci., 1995, 92, 4507.
9. 9. Haldar, S., Chintapalli, J. and Croce, C., Taxol-induced BCL-2 phosphorylation and death of prostate cancer cells. Cance Research, 1996, 56, 1253.
10. 10. Vescio, R. A., Hong, C. H., Cao, J., Kim, A., Schiller, G. J., Lichtenstein, A., Berenson, R. and Berenson, J., The hematopoietic stem cell antigen, CD34, is not expressed on the malignant cells in multiple myeloma. Blood, 1994, 84, 3283.
11. 11. McConkey, D. J., Chandra, J., Wright, S., Plunkett, W., McDonnell, T. J., Reed, J. C. and Keating, M., Apoptosis sensitivity in CLL is determined by endogenous endonuclease content and relative expression of BCL-2 and BAX. Journal of Immunology, 1996, 156, 2624.
12. 12. Dalton, W. S., Durie, B. G. M., Alberts, D. S., Gerlach, J. H. and Cress, A. E., Characterization of a new drug-resistant myeloma cell line that expresses P-glycoprotein. Cancer Research, 1986, 46, 5125.
13. 13. Huang, Y., Ibrado, A. M., Reed, J. C., Bullock, G., Ray, S., Tang, C. and Bhalla, K., Co-expression of several molecular mechanisms of multidrug resistance and their significance for paclitaxel cytotoxicity in human AML HL-60 cells. Leukemia, 1997, 11, 253.
14. 14. Memon, S. A., Moreno, M. B., Petrak, D. and Zacharchuk, C. M., BCL-2 blocks glucocorticoid-but not fas-or activation-induced apoptosis in a T cell hybridoma. Journal of Immunology, 1995, 155, 4644.
15. 15. Blagosklonny, M. V., Schulte, T., Nguyen, P., Trepel, J. and Neckers, L. M., Taxol-induced apoptosis and phosphorylation of BCL-2 protein involves c-Raf-1 and represents a novel c-Raf-1 signal transduction pathway. Cancer Research, 1996, 56, 1851.
16. 16. Ibrado, A. M., Liu, L. and Bhalla, K., BCL-X-L overexpression inhibits progression of molecular events leading to paclitaxel-induced apoptosis of human acute myeloid leukemia HL-60 cells. Cancer Research, 1997, 57, 1109.
17. 17. Tang, C., Willingham, M. C., Reed, J. C., Miyashita, T., Ray, S., Ponnathpur, V., Huang, Y., Mahoney, M. E., Bullock, G. and Bhalla, K., High levels of p26BCL-2 oncoprotein retard taxol-induced apoptosis in human pre-B leukemia cells. Leukemia, 1994, 8, 1960.
18. 18. Strobel, T., Swanson, L., Korsmeyer, S. and Cannistra, S., BAX enhances paclitaxel-induced apoptosis through a p53-independent pathway. Proc. Natl. Acad. Sci., 1996, 93, 14094.
19. 19. Rowinsky, E., Clinical pharmacology of taxol. Journal of the National Cancer Institute Monograph, 1993, 15, 25.
20. 20. Krajewski, S., Krajewski, M., Shabaik, A., Wang, H.-G., Irie, S., Fong, L. and Reed, J. C., Immunohistochemical analysis of in vivo patterns of BCL-X expression. Cancer Research, 1994, 54, 5501.
21. 21. Ibrado, A. M., Huang, Y., Fang, G. and Bhalla, K., BCL-X-L overexpression inhibits taxol-induced Yama protease activity and apoptosis. Cell Growth & Differ., 1996, 7, 1087.
22. 22. Haldar, S., Basu, A. and Croce, C., BCL-2 is the guardian of microtubule integrity. Cancer Research, 1997, 57, 229.
23. 23. Dimopoulos, M. A., Arbuck, S., Huber, M., Weber, D., Luckett, R., Delasalle, K. and Alexanian, R., Primary therapy of multiple myeloma with paclitaxel. Annals of Oncology, 1994, 5, 757.
24. 24. Epstein, J., Xiao, H. and Oba, B. K., P-glycoprotein expression in plasma cell myeloma is associated with resistance to VAD. Blood, 1989, 74, 913.
25. 25. Lehnert, M., Emerson, S., Dalton, W. S., de Giuli, R. and Salmon, S. E., In vitro evaluation of chemosensitizers for clinical reversal of p-glycoprotein-associated taxol resistance. Journal of the National Cancer Institute Monograph, 1993, 15, 63.
26. 26. Aime-Sempe, C., Kitada, S. and Reed, J.C., Investigations of taxol-mediated phosphorylation of BCL-2. Proc. Amer. Assoc. Cancer Research, 1997, 38, 171 (abstract No. 114).
27. 27. York, J., Wolpert-DeFilppes, M. K., Johns, D. G. and Sethi, V. S., Binding of maytansinoids to tubulin. Biochem. Pharm., 1981, 30, 3239.
28. 28. Mandelbaum-Shavit, F., Wolpert-DeFilippes, M. K. and Johns, D. G., Binding of maytansine to rat brain tubulin. Biochem. and Biophys. Res. Commun., 1990, 72, 47.