Weight gain associated with protease inhibitor therapy in HIV-infected patients

Research in Virology

Volumn 149, Issue 2, 1998, Pages 123-126

  Stricker, R B ^a   Goldberg, B ^b  

^a CALIFORNIA PACIFIC MEDICAL CENTER   (United States)

^b Dinitrochlorobenzene Study Group   (United States)

Author keywords

AIDS; Gain; HIV; Protease inhibitor; Viral load; Wasting; Weight

Indexed keywords

INDINAVIR; LAMIVUDINE; PROTEINASE INHIBITOR; RITONAVIR; SAQUINAVIR; STAVUDINE;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ARTICLE; BODY WEIGHT; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; HUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; PROPHYLAXIS; SIDE EFFECT; WEIGHT GAIN;

RNA VIRUSES;

EID: 0032033097     PISSN: 09232516     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0923-2516(98)80088-5     Document Type: Article

References (14)

1. Authier, F., Mort, J.S., Bell, A.W., Posner, B.I. & Bergeron, J.J. (1995), Proteolysis of glucagon within hepatic endosomes by membrane-associated cathepsins B and D. J. Biol. Chem., 270, 15798-15807.
2. Bohley, P. & Seglen, P.O. (1992), Proteases and proteolysis in the lysosome. Experientia, 48, 151-157.
3. Cat, L.K. & Coleman, R.L. (1994), Treatment for HIV wasting syndrome. Ann. Pharmacother., 28, 595-597.
4. Coodley, G.O., Loveless, M.O. & Merrill, T.M. (1994), The HIV wasting syndrome: a review. J. AIDS, 7, 681-694.
5. Deeks, S.G., Smith, M., Holodniy, M. & Kahn, J.O. (1997), HIV-1 protease inhibitors. A review for clinicians. JAMA, 277, 145-153.
6. DuPont, H.L. & Marshall, G.D. (1995), HIV-associated diarrhoea and wasting. Lancet, 346, 352-356.
7. Frost, R.A., Fuhrer, J., Steigbigel, R., Mariuz, P., Lang, C.H. & Gelato, M.C. (1996), Wasting in the acquired immunodeficiency syndrome is associated with multiple defects in the serum insulin-like growth factor system. Clin. Endocrinol., 44, 501-514.
8. Goldberg, B. & Stricker, R.B. (1996), HIV protease and the pathogenesis of AIDS. Res. Virol., 147, 375-379.
9. Nahlen, B.L., Chu, S.Y., Nwanyanwu, O.C., Berkelman, R.L., Martinez, S.A. & Rullan, J.V. (1993), HIV wasting syndrome in the United States. AIDS, 7, 183-188.
10. Rajah, R., Katz, L., Nunn, S., Solberg, P., Beers, T. & Cohen, P. (1995), Insulin-like growth factor binding protein (IGFBP) proteases: functional regulators of cell growth. Prog. Growth Factor Res., 6, 273-284.
11. Sorkin, J.D., Bolton, P.A., Greenblatt, J., Sithisarankul, P., Vlahov, D. & Graham, N.M. (1995), Age, gender, and other predictors of the wasting syndrome among HIV-1-infected infecting drug users. Epidemiology, 6, 172-177.
12. Von Roenn, J.H. (1994), Management of HIV-related body weight loss. Drugs, 47, 774-783.
13. Weinroth, S.E., Parenti, D.M. & Simon, G.L. (1995), Wasting syndrome in AIDS: pathophysiologic mechanisms and therapeutic approaches. Infect. Agents Dis., 4, 76-94.
14. Zangerle, R., Reibnegger, G., Wachter, H. & Fuchs, D. (1993), Weight loss in HIV-1 infection is associated with immune activation. AIDS, 7, 175-181.