The effects of intra-articular methylprednisolone and exercise on the mechanical properties of articular cartilage in the horse

Osteoarthritis and Cartilage

Volumn 6, Issue 2, 1998, Pages 106-114

  Murray, Rachel C ^a,d   Debowes, Richard M ^b   Gaughan, E M ^b   Zhu, C F ^c   Athanasiou, KyriacosK A ^c  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b KANSAS STATE UNIVERSITY   (United States)

^c UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^d ANIMAL HEALTH TRUST   (United Kingdom)

Author keywords

Articular cartilage; Biomechanics; Cartilage material properties; Equine

Indexed keywords

CORTICOSTEROID; DILUENT; METHYLPREDNISOLONE ACETATE;

ANIMAL EXPERIMENT; ANIMAL LAMENESS; ANIMAL TISSUE; ARTICLE; ARTICULAR CARTILAGE; BIOMECHANICS; CARPAL BONE; CARTILAGE CELL; CARTILAGE MATRIX; CELL DEATH; COLLAGEN SYNTHESIS; CONTROLLED STUDY; FEMALE; JOINT DEGENERATION; NONHUMAN; OSTEOARTHRITIS; PERMEABILITY; PRIORITY JOURNAL; PROTEOGLYCAN SYNTHESIS; TREADMILL EXERCISE;

EID: 0032032702     PISSN: 10634584     EISSN: None     Source Type: Journal    
DOI: 10.1053/joca.1997.0100     Document Type: Article

References (48)

1. 1. Gray RG, Gottleib NL. Intraarticular corticosteroids. An updated assessment. Clin Orthop 1993;177: 235-63.
2. 2. Chatham W, Williams G, Moreland L, et al. Intraarticular corticosteroid injections: Should we rest the joints? Arthritis Care and Research 1989;2:70-4.
3. 3. Pelletier JP, Martel-Pelletier J. Protective effects of corticosteroids on cartilage lesions and osteophyte formation in the Pond-Nuki dog model of osteoarthritis. Arthritis Rheum 1989;32:181-93.
4. 4. Klamfeldt A. Effect of indomethacin and hydrocortisone upon joint tissue in vitro. Scand J Rheumatol 1985;14:225-9.
5. 5. Auer JA, Fackelman GE. Treatment of degenerative joint disease of the horse: A review of and commentary. Vet Surg 1981;10:80-9.
6. 6. Annefeld M, Erne B, Rasser Y. Ultrastructural analysis of rat articular cartilage following treatment with dexamethasone and glycosaminoglycan complex. Clin Exp Rheumatol 1990;8:151-7.
7. 7. Hackett RP. Intra-articular use of corticosteroids in the horse. J Am Vet Med Assoc 1982;181:292-4.
8. 8. Bertone AL, Carter BG, Weisbrode SE, Bailey MQ, Andrews JM, Palmer JL. Influence of steroid suppression on more and less weight-bearing osteochondral defects in equine tarsocrural joints. (Abstract) Proc Vet Orthop Soc, 1993.
9. 9. Shoemaker RS, Bertone AL, Martin GS, et al. Effects of intra-articular administration of methylprednisolone acetate on normal articular cartilage and on healing of experimentally induced osteochondral defects in horses. Am J Vet Res 1992;53: 1446-53.
10. 10. Athanasiou KA, Agarwal A, Dzida FJ. A comparative study of the biomechanical properties of human acetabular and femoral head cartilage. J Orthop Res 1994;12:340-9.
11. 11. Athanasiou KA, Agarwal A, Muffoletto A, Dzida FJ, Constantinides G, Clem M. Biomechanical properties of hip cartilage in experimental animal models. Clin Orthop 1995;316:254-66.
12. 12. Schenck RC, Athanasiou KA, Constantinides G, Gomez E. A biomechanical analysis of articular cartilage of the human elbow and a potential relationship to osteochondritis dissecans. Clin Orthop 1994;299:305-12.
13. 13. Pelletier J, Martel-Pelletier J. Cartilage degradation by neutral proteoglycanases in experimental osteoarthritis: suppression by steroids. Arthritis Rheum 1985;28:1393-401.
14. 14. Meagher DM. The effects of intra-articular corticosteroids and continued training on carpal chip fractures of horses. Proc Am Assoc Eq Prac 1970;405-20.
15. 15. Owen Rh, Marsh JA, Hallett FR, Lumsden JH, Johnson J. Intra-articular corticosteroid- and exercise-induced arthropathy in a horse. J Am Vet Med Assoc 1984;184:302-8.
16. 16. Kolibas LM, Goldberg RL. Effect of cytokines and antiarthritic drugs on glycosaminoglycan synthesis by bovine articular chondrocytes. Agents and Actions 1989;27:245-9.
17. 17. Hainque B, Dominice J, Jaffray P, Ronot X, Adophe M. Effects of dexamethasone on the growth of cultured rabbit articular chondrocytes: relation with the nuclear glucocorticoid-receptor complex. Ann Rheum Dis 1987;46:146-52.
18. 18. Chunekamrai S, Krook LP, Lust G, Maylin GA. Changes in articular cartilage after intra-articular injections of methylprednisolone acetate in horses. Am J Vet Res 1989;50:1733-40.
19. 19. Trotter GW, McIlwraith CW, Yovich JV, Norrdin RW, Wrigley RH, Lamar CH. Effects of intraarticular administration of methylprednisolone acetate on normal equine articular cartilage. Am J Vet Res 1991;52:83-7.
20. 20. Sharp GWG. The effect of cortisol and certain synthetic steroids on the permeability of synovial membrane in the rabbit. J Endocrinol 1963;25: 443-50.
21. 21. Steinberg J, Sledge CB. Synovial factors and chondrocyte mediated breakdown of cartilage: inhibition by hydrocortisone. J Orthop Res 1983;1:13-21.
22. 22. Steinberg JJ, Kincaid SB, Sledge CB. Inhibition of cartilage breakdown by hydrocortisone in a tissue culture model of rheumatoid arthritis: Ann Rheum Dis 1983;42:323-30.
23. 23. Pelletier JP, Cloutier JM, Martel-Pelletier J. In vitro effects of tiprofenic acid, sodium salicylate and hydrocortisone on the proteoglycan metabolism of human osteoarthritic cartilage. J Rheumatol 1989;16:646-55.
24. 24. Pelletier JP, Martel-Pelletier J, Cloutier JM, Woessner JF. Proteoglycan-degrading acid metalloprotease activity in human osteoarthritic cartilage and the effect of intraarticular steroid injections. Arthritis Rheum 1987;30:541-8.
25. 25. Murray RC, DeBowes RM, Gaughan EM, Mosier D, Athanasiou KA. Variations in the biomechanical properties of articular cartilage of the midcarpal joint of normal horses. V.C.O.T 1995;8:133-40.
26. 26. Harkins JD, Kamerling SG, Bagwell, Karns PA. A comparative study of interval and conventional training in thoroughbred racehorses. Equine Vet J supp 1990;9:14-9.
27. 27. Evans DL. Training Thoroughbred racehorses. In Hodgson DR, Rose RJ, Eds. The athletic horse: Principles and Practice of Equine Sports Medicine. Philadelphia, PA: WB Saunders 1994:393-7.
28. 28. Mak AF, Lai WM, Mow VC. Biphasic indentation of articular cartilage-I. Theoretical solution. J Biomechanics 1987;20:703-14.
29. 29. Mow V, Gibbs M, Lai W, Zhu W, Athanasiou KA. Biphasic creep and stress relaxation of articular cartilage ii: A numerical algorithm and experimental study. J Biomech 1989;22:853-61.
30. 30. Mow V, Kuei S, Lai W, Armstrong C. Biphasic creep and stress relaxation of articular cartilage in compression: Theory and experiments. J Biomech Eng 1980;102:73-84.
31. 31. Spilker R, Suh J. Formulation and evaluation of a finite element model for the biphasic model of hydrated soft tissues. Comp Struc 1990;35:425-39.
32. 32. Vanderplaats G. ADS - a FORTRAN program for automated design synthesis. Engineering Design Optimization, Inc. 1981.
33. 33. Athanasiou KA, Rosenwasser MP, Buckwalter JA, Malinin TI, Mow VC. Interspecies comparisons of In Situ Intrinsic Mechanical Properties of Distal Femoral Cartilage. J Orthop Res 1991;9:330-40.
34. 34. Behrens F, Shepard RT, Mitchell N. Metabolic recovery of articular cartilage after intraarticular injections of glucocorticoid. J Bone Joint Surg [Am] 1976;58:1157-60.
35. 35. Roberts S, Weightman B, Urban J, Chappel D. Mechanical and biochemical properties of human articular cartilage in osteoarthritic femoral heads and in autopsy specimens. J Bone Joint Surg [Br] 1986;68:278-88.
36. 36. Armstrong CG, Mow VC. Biomechanics of normal and osteoarthrotic articular cartilage. In: Wilson PD, Straub LR, Eds. Clinical Trends in Orthopaedics. New York: Thieme-Stratton 1982:189-97.
37. 37. Armstrong CG, Mow VC. Variations in the intrinsic mechanical properties of human articular cartilage with age, degeneration, and water content. J Bone Joint Surg [Am] 1982;64:88-94.
38. 38. Palmer SE. Prevalence of carpal fractures in Thoroughbred and Standardbred racehorses. J Am Vet Med Assoc 1986;188:1171-3.
39. 39. Park RD, Morgan JP, O'Brien T. Chip fractures in the carpus of the horse: A radiographic study of their incidence and location. J Am Vet Med Assoc 1970;157:1305-12.
40. 40. Burton-Wurster N, Lust G. Deposition of fibronectin in articular cartilage of canine osteoarthritic joints. Am J Vet Res 1985;46:2542-5.
41. 41. Jones KL, Brown M, Ali SY, et al. An immunohistochemical study of fibronectin in human osteoarthritic and disease free articular cartilage. Ann Rheum Dis 1987;46:809-15.
42. 42. Fubini SL, Boatwright CE, Todhunter RJ, Lust G. Effect of intramuscularly administered polysulfated glycosaminoglycan on articular cartilage from equine joints injected with methylprednisolone acetate. Am J Vet Res 1993;54:1359-65.
43. 43. Ribeiro RF, Campos JCP, Compere EL, DiDio LJA. Alterations of the knee joint of rabbits after intraarticular injection of high doses of corticosteroid. International Surgery 1968;50:133-8.
44. 44. Noyes FR, Grood ES, Nussbaum NS, Cooper SM. Effect of intraarticular corticosteroids on ligament properties. A biomechanical and histological study in Rhesus knees. Clin Orthop 1977;123: 197-209.
45. 45. Autefage A, Alvinerie M, Toutain PL. Synovial fluid and plasma kinetics of methylprednisolone and methylprednisolone acetate in horses following intraarticular administration of methylprednisolone acetate. Equine Vet J 1986;18: 193-8.
46. 46. Rusanen M, Gronblad M, Korkala O. Scanning electron microscopical study of the effects of crystalloid and water-soluble glucocorticoids on articular cartilage. Scand J Rheumatol 1986;15: 47-51.
47. 47. Lillich JD, Bertone AL, Schmall LM, Ruggles AJ, Sams RA. Plasma, Urine and synovial fluid disposition of MPA and isoflupredone acetate after intraarticular administration in horses. Am J Vet Res 1996;57:187-92.
48. 48. Palmer JL, Bertone AL, Mansour J, Carter BG, Malemud CJ. Biomechanical properties of third carpal articular cartilage in exercised and nonexercised horses. J Orthop Res 1995;13: 854-60.