The effect of short-term estrogen replacement therapy on cognition: A randomized, double-blind, cross-over trial in postmenopausal women

Obstetrics and Gynecology

Volumn 91, Issue 3, 1998, Pages 459-466

  Portin, Raija ^a   Polo, Olli ^b   Helenius, Hans ^a   Erkkola, Risto ^b  

^a TURKU UNIVERSITY HOSPITAL   (Finland)

^b UNIVERSITY OF TURKU   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

ESTRADIOL;

ADULT; AGE; AGED; ARTICLE; CLINICAL TRIAL; COGNITION; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; DRUG EFFECT; ESTROGEN BLOOD LEVEL; ESTROGEN THERAPY; FEMALE; HUMAN; NORMAL HUMAN; POSTMENOPAUSE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; TRANSDERMAL DRUG ADMINISTRATION;

AGED; COGNITION; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; ESTROGEN REPLACEMENT THERAPY; FEMALE; HUMANS; MIDDLE AGED; NEUROPSYCHOLOGICAL TESTS; POSTMENOPAUSE; TIME FACTORS;

EID: 0032031391     PISSN: 00297844     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0029-7844(97)00700-X     Document Type: Article

References (32)

1. Eiliger B. Overview of the efficacy of hormonal replacement therapy. Am j Obstet Gynecol 1987;156:1298-303.
2. Shenvin BB. Estrogen and/or androgen replacement therapy and cognitive functioning in surgically menopausal women. Psychoneuroendocrinology 1988;13:345-57.
3. Kämpen DL, Shenvin BB. Estrogen use and verbal memory in healthy postmenopausal women. Obstet Gynecol 1994;83:979-83.
4. Geffen G, Moar GJ, O'Hanlon AP, Clark CR, Geffen LB. Perfor-mance measures of 16- to 68-year-old males and females on the auditory verbal learning test. Clin Neuropsychol 1990;4:45-63.
5. Fedor-Freyberg P. The influence of oestrogen on the well-being and mental performance in climacteric and postmenopausal women. Acta Obstet Gynecol Scand 1977;64:5-69.
6. Vanhulle G, Demol R. A double-blind study into the influence of estriol on a number of psychological tests in post-menopausal women. In: van Keep PA, Greenblatt RB, Albeaux-Fernet M, eds. Consensus on menopausal research. London: MTP Press, 1976: 94-9.
7. Barrett-Connor E, Kritz-Silverstein D. Estrogen replacement therapy and cognitive function in older women. JAMA 1993;269:263741.
8. Salthouse TA. Speed of behavior and its implications for cognition. In: Birren JE, Schale KW, eds. Handbook of the psychology of aging. 2nd ed. New York: Van Nostrand Reinhold Co., 1985:40022.
9. Pfaff DVV, McEwen B. Actions of oestrogens and progestones on nerve cells. Science 1983;219:808-14.
10. Bixo M, Bäckström T, VVinblad B, Andersson A. Estradiol and testosterone in specific regions of the human female brain in different endocrine states. J Steroid Biochem Mol Biol 1995;55:297303.
11. Matsumoto A, Arai Y, Osanai M. Estrogen stimulates neuronal plasticity in the deafferented hypothalamic arcuate nucleus in aged female rats. Neurosci Res 1985;2:412-8.
12. Arimatsu Y, Hatamaka H. Estrogen treatment enhances survival of cultured amygdala neurons in a defined medium. Dev Brain Res 1986;26:151-9.
13. Gould E, Woolley CS, Frankfurt M, McEwen BS. Gonadal steroids regulate dendritic spine density in hippocampal pyramidal cells in adulthood. J Neurosci 1990;10:1286-91.
14. Luine VN, Park D, Job. T, Reis D, McEwen B. Immuno-chemical demonstration of increased choline acetyltransferase concentration in rat preoptic area after estradiol administration. Brain Res 1980;191:273-7.
15. Bartus RT, Dean RL, Beer B, Lippa AS. The cholinergic hypothesis of memory dysfunction. Science 1982;17:408-17.
16. Di Paolo T. Modulation of brain dopamine transmission by sex steroids. Rev Neurosci 1994;5:27-41.
17. Williams GV, Goldman-Rakic PS. Modulation of memory fields by dopamine Dl receptors in prefrontal cortex. Nature 1995;376: 572-5.
18. Folstein.MF, Folstein SE, McHugh PR. 'Mini-Mental State': a practical method for grading the cognitive state of patients for clinician. J Psychiatr Res 1975;12:189-98.
19. Portin R, Rinne UK. Neuropsychological responses of parkinsonian patients to long-term levodopa treatment. In: Rinne UK, Klingler M, Stamm G, eds. Parkinson's disease-current progress, problems and management. Amsterdam: Biomédical Press, 1980: 271-304.
20. Kujala P, Portin R, Ruutiainen J. Memory deficits and early cognitive deterioration in MS. Acta Neurol Scand 1996;93:329-35.
21. Wechsler D. Manual for the Wechsler adult intelligence scale. New York: Psychological Corp., 1955.
22. Benton AL. Revised visual retention test. New York: Psychological Corp., 1963.
23. Revonsuo A, Portin R. CogniSpeed: The computer based measurement of cognitive processing. Turku, Finland: AboaTech LTD, University of Turku, 1995.
24. Gronwall DMA. Paced auditory serial addition task: Measure of recovery from concussion. Percept Mot Skill 1977;44:367-73.
25. Beck AT, Ward CH, Mendelson M, Mock J, Erbaugh J. An inventory for measuring depression. Arch Gen Psychiatry 1961;4: 561-71.
26. Stroop JR. Studies of interference in serial verbal reactions. J Exp Psychol 1835;18:643-62.
27. Jones B, Kenward MG. Design and analysis of cross-over trials. London: Chapman and Hall, 1989.
28. La Rue A. Aging and neuropsychological assessment. New York: Plenum Press, 1992.
29. Sherwin BB, Phillips S. Estrogen and cognitive functioning in surgically menopausal women. Ann N Y Acad Sei 1990;592:474-5.
30. Baars B. A cognitive theory of consciousness. Cambridge: Cambridge University Press, 1988. \
31. Ditkoff EC, Crary \VR, Cristo M, Lobo RA. Estrogen improYes psychological function in asymptomatic postmenopausal women. Obstet Gynecol 1991;7S:991-5.
32. Swirsky-Sacchetti T, Field HL, Mitchell DR, Seward J, Lublin FD, Knobler RL, et al. The sensitivity of the mini-mental state exam in the white matter dementia of multiple sclerosis. J Clin Psychol 1992;48:779-86.