Binding profiles and physical dependence liabilities of selected benzodiazepine receptor ligands

Brain Research Bulletin

Volumn 45, Issue 4, 1998, Pages 381-387

  Richards, J Grayson ^a   Martin, James R ^a  

^a F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

Benzodiazepine receptor; Bretazenil; Diazepam; In vitro binding; Monkeys; Physical dependence; Rats; Ro 19 8022; Ro 43 9824; Zolpidem

Indexed keywords

BENZODIAZEPINE RECEPTOR AFFECTING AGENT; BENZODIAZEPINE RECEPTOR STIMULATING AGENT; BRETAZENIL; DIAZEPAM; RECEPTOR SUBTYPE; RO 19 8022; RO 43 9624; UNCLASSIFIED DRUG; ZOLPIDEM;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; BINDING AFFINITY; BINDING KINETICS; DRUG BINDING; DRUG DEPENDENCE; DRUG RECEPTOR BINDING; LIGAND BINDING; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; ANTI-ANXIETY AGENTS; BENZODIAZEPINES; BRAIN CHEMISTRY; CONFLICT (PSYCHOLOGY); EATING; GABA MODULATORS; LIGANDS; MALE; MUSCULOSKELETAL EQUILIBRIUM; RATS; RATS, INBRED STRAINS; RECEPTORS, GABA-A; SAIMIRI; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTANCE WITHDRAWAL SYNDROME; SUBSTANCE-RELATED DISORDERS;

EID: 0032030978     PISSN: 03619230     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0361-9230(97)00370-5     Document Type: Article

References (19)

1. A receptor channel A mechanism for interaction with a multitude of central nervous system functions . Möhler H., Da Prada M. The challenge of neuropharmacology. 1994;15-39 Editiones Roche, Basel.
2. Haefely W., Facklam M., Schoch P., Martin J. R., Bonetti E. P., Moreau J. -L., Jenck F., Richards J. G. Partial agonists of benzodiazepine receptors for the treatment of epilepsy, sleep, and anxiety disorders. Biggio G., Concas A., Costa E. GABAergic synaptic transmission. 1991;379-394 Raven Press, New York.
3. Haefely W., Martin J. R., Schoch P. Novel anxiolytics that act as partial agonists at benzodiazepine receptors. Trends Pharmacol. Sci. 11:1990;452-456.
4. Jenck F., Moreau J. -L., Bonetti E. P., Martin J. R., Haefely W. E. Ro 19-8022, a nonbenzodiazepine partial agonist at benzodiazepine receptors Neuropharmacological profile of a potential anxiolytic . J. Pharmacol. Exp. Ther. 262:1992;1121-1127.
5. Martin J. R., Jenck F., Moreau J. -L. Comparison of benzodiazepine receptor partial agonists, antagonists and a partial inverse agonist in reversing flunitrazepam-induced sleep and in precipitating diazepam-withdrawal in squirrel monkeys. J. Pharmacol. Exp. Ther. 275:1995;405-411.
6. Martin J. R., Kuwahara A., Horii I., Moreau J. -L., Jenck F., Sepinwall J., Haefely W. E. Evidence that the benzodiazepine receptor partial agonist Ro 16-6028 has minimal abuse and physical dependence liability. Soc. Neurosci. Abstr. 16:1990;1104.
7. Martin J. R., Moreau J. -L., Jenck F. Evaluation of the dependence liability of quinolizinones acting as partial agonists at the benzodiazepine receptor. Drug Dev. Res. 36:1995;141-149.
8. Martin J. R., Moreau J. -L., Jenck F. Precipitated withdrawal in squirrel monkeys after repeated daily oral administration of alprazolam, diazepam, flunitrazepam or oxazepam. Psychopharmacology. 118:1995;273-279.
9. Martin J. R., Pieri L., Bonetti E. P., Schaffner R., Burkard W. P., Cumin R., Haefely W. E. Ro 16-6028 A novel anxiolytic acting as a partial agonist at the benzodiazepine receptor . Pharmacopsychiatry. 21:1988;360-362.
10. Martin J. R., Schoch P., Jenck F., Moreau J. -L., Haefely W. E. Pharmacological characterization of benzociazepine receptor ligands with intrinsic efficacies ranging from high to zero. Psychopharmacology. 111:1993;415-422.
11. A receptors and anxiety From neurobiology to treatment . 1995;41-56 Raven Press, New York.
12. Perrault G., Morel E., Sanger D. J., Zivkovic B. Lack of tolerance and physical dependence upon repeated treatment with the novel hypnotic zolpidem. J. Pharmacol. Exp. Ther. 263:1992;298-303.
13. Richards J. G., Möhler H., Haefely W. Mapping benzodiazepine receptors in the CNS by radiohistochemistry and immunohistochemistry. Pannula P., Paivarinta H., Soinila S. Neurohistochemistry, modern methods and applications. 1986;629-677 Alan R. Liss, New York.
14. Richards G., Schoch P., Haefely W. Benzodiazepine receptors New vistas . Semin. Neurosci. 3:1991;191-203.
15. Sanger D. J., Joly D., Zivkovic B. The behavioral pharmacology of zolpidem Comparisons with other compounds acting at the benzodiazepine receptor . Sauvanet J. P., Langer S. Z., Morselli P. L. Imidazopyridines in sleep disorders. 1988;111-121 Raven Press, New York.
16. Sannerud C. A., Ator N. A., Griffiths R. R. Behavioral pharmacology in baboons Self-injection, drug discrimination and physical dependence . Behav. Pharmacol. 3:1992;507-516.
17. Schoch P., Moreau J. -L., Martin J. R., Haefely W. E. Aspects of benzodiazepine structure and function with relevance to drug tolerance and dependence. Wonnacot S., Lunt G. G. Neurochemistry of drug dependence. 1993;121-134 Portland Press, London.
18. Woods J. H., Katz J. L., Winger G. Benzodiazepines Use, abuse, and consequences . Pharmacol. Rev. 44:1992;151-347.
19. Zivkovic B., Perrault G., Morel E., Sanger D. J. Comparative pharmacology of zolpidem and other hypnotics and sleep inducers. Sauvenet J. P., Langer S. Z., Morselli P. L. Imidazopyridines in sleep disorders. 1988;97-109 Raven Press, New York.