Synthesis and preliminary antileukemic studies of cyclic mitoguazone analogues

Farmaco

Volumn 53, Issue 3, 1998, Pages 244-247

  Krȩzel, Izabella ^a   Graczyk, Julita ^a  

^a MEDICAL UNIVERSITY OF LODZ   (Poland)

Author keywords

Antileukemic studies; Mitoguazone analogues

Indexed keywords

3,4 (METHYLENEDIOXY)BENZALDEHYDE (4,5,6,7 TETRAHYDRO 1H 1,3 DIAZEPIN 2 YL)METHYLHYDRAZONE HYDROIODIDE; ANTILEUKEMIC AGENT; MITOGUAZONE; UNCLASSIFIED DRUG;

ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG DESIGN; DRUG SCREENING; DRUG SYNTHESIS; INTRAPERITONEAL DRUG ADMINISTRATION; LEUKEMIA; MOUSE; NONHUMAN; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; SURVIVAL; TOXICITY TESTING; TREATMENT OUTCOME;

ANIMALS; ANTINEOPLASTIC AGENTS; LEUKEMIA L1210; MICE; MICE, INBRED DBA; MITOGUAZONE; MOLECULAR STRUCTURE;

EID: 0032029933     PISSN: 0014827X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-827X(98)00011-1     Document Type: Article

References (16)

1. [1] P.H. Richter, I. Wunderlich, H. Schleuder, A. Keckeis, Pharmazie 48 (1993) 163.
2. [2] Bisanthrene Hydrochloride, Drugs Future, 14 (1989) 1213.
3. [3] Ambazone, Drugs Future, 15 (1990) 1071.
4. [4] J. Janne, L. Alhonen, P. Leinenen, Ann. Med. 23 (1991) 241.
5. [5] A.E. Pegg, Cancer Res. 48 (1988) 759.
6. [6] D. Sidzhakowa, B. Panajotowa, Z. Mardirossjan, S. Tabakova, L. Manewa, V. Marinova, E. Golovinsky, Pharmazie 48 (1993) 417.
7. [7] P. Seppanen, R. Fagerstrom, L. Alhonnen-Hongisto, H. Elo, P. Lumme, J. Janne, J. Biochem. 221 (1984) 483.
8. [8] K. Igarashi, D.R. Morris, Cancer Res. 44 (1982) 5332.
9. [9] I. Kreżel, Pharmazie 50 (1995) 430.
10. [10] K. Shyam, R.T. Hrubiec, R. Furubayashi, L.A. Cosby, A.C. Sartorelli, J. Med. Chem. 30 (1986) 1323.
11. [11] G.P. Wheeler, S. Chumley, J. Med. Chem. 10 (1967) 259.
12. [12] C.F. Bell, G.F. Mortimore, Org. Magn. Reson. 7 (1975) 512.
13. [13] W.C. Hamilton, S.J. La Placa, Acta Crystallogr. 824 (1968) 1147.
14. [14] L. Li, H.-K. Wang, S.-Ch. Kuo, T.-S. Wu, D. Lednicer, Ch.M. Lin, E. Hamel, K.-H. Lee, J. Med. Chem. 37 (1994) 1126.
15. [15] R.J. Geran, N.H. Greenberg, M.M. Mac Donald, A.M. Schumacher, B.J. Abbot, Cancer Chemother. 3 (1992) 1.
16. [16] W.B. Deichmann, T. Le Blanck, Ind. Hyg. Toxicol. 25 (1945) 415.