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Volumn 108, Issue 9, 1998, Pages 3630-3647

Spurious cooperativity in alkylated succinic acids

Author keywords

[No Author keywords available]

Indexed keywords

ACIDS; CALCULATIONS; CONFORMATIONS; DISSOCIATION; HYDROGEN BONDS; MATHEMATICAL MODELS; PERMITTIVITY; PROTONS;

EID: 0032023745     PISSN: 00219606     EISSN: None     Source Type: Journal    
DOI: 10.1063/1.475758     Document Type: Article
Times cited : (6)

References (29)
  • 5
    • 2742575689 scopus 로고
    • L. Eberson, Acta Chem. Scand. 13, 211,224 (1959); L. Eberson, ibid., 13, 224 (1959).
    • (1959) Acta Chem. Scand. , vol.13 , pp. 211
    • Eberson, L.1
  • 6
    • 11744295445 scopus 로고
    • L. Eberson, Acta Chem. Scand. 13, 211,224 (1959); L. Eberson, ibid., 13, 224 (1959).
    • (1959) Acta Chem. Scand. , vol.13 , pp. 224
    • Eberson, L.1
  • 7
    • 11744338195 scopus 로고
    • edited by S. Patai, Wiley, New York, Chap. 6
    • L. Eberson, in Carboxylic Acids and Esters, edited by S. Patai, (Wiley, New York, 1992), Chap. 6.
    • (1992) Carboxylic Acids and Esters
    • Eberson, L.1
  • 14
    • 85034290254 scopus 로고    scopus 로고
    • note
    • It should be noted, however, that if one uses the (A.V.) Hill coefficient as a measure of cooperativity one can easily be misled by the shape or form of the BI. For instance, Wyman and Gill correctly pointed out that "since there is only one binding site, there can be no cooperativity" (page 51 of Ref. 14). Three pages later, referring to the same single-site system, noticing the slope of the frozen in curve, they conclude "thus the cooperativity is negative" (page 54 of Ref. 14). Not less confusing is the practice of using the terms macroscopic and microscopic cooperativities (see Refs. 15 and 16). One is based on the (A.V.) Hill coefficient and the second is essentially the same as used in Ref. 10 and in the present paper. All this confusion could have been avoided had scientists heeded (T.L.) Hill's warning (see Ref. 12) - and further stressed by Ben-Naim (see Ref. 17) - not to use the (A.V.) Hill coefficient as a measure of cooperativity.
  • 19
    • 85034288639 scopus 로고    scopus 로고
    • note
    • H=1/2. If the ligand is a single enatiomer of an optically active molecule it can, in principle, bind very differently to L and H.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.