Effects of some thiol chelators on enzymatic activities in blood, liver and kidneys of acute arsenic (III) exposed mice

Biomedical and Environmental Sciences

Volumn 11, Issue 1, 1998, Pages 38-45

  Tripathi, Neelima ^a   Flora, S J S ^a  

^a DEFENCE RESEARCH AND DEVELOPMENT ESTABLISHMENT   (India)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ARSENITE SODIUM; ARSENOUS ACID DERIVATIVE; ASPARTATE AMINOTRANSFERASE; CHELATING AGENT; GAMMA GLUTAMYLTRANSFERASE; PORPHOBILINOGEN SYNTHASE; S ADENOSYLMETHIONINE; SODIUM DERIVATIVE; SUCCIMER; UNITHIOL;

ANIMAL; ARTICLE; BLOOD; DRUG EFFECT; ENZYMOLOGY; KIDNEY; LIVER; MALE; METABOLISM; MOUSE; STRUCTURE ACTIVITY RELATION;

ALANINE TRANSAMINASE; ALKALINE PHOSPHATASE; ANIMALS; ARSENITES; ASPARTATE AMINOTRANSFERASES; CHELATING AGENTS; GAMMA-GLUTAMYLTRANSFERASE; KIDNEY; LIVER; MALE; MICE; PORPHOBILINOGEN SYNTHASE; S-ADENOSYLMETHIONINE; SODIUM COMPOUNDS; STRUCTURE-ACTIVITY RELATIONSHIP; SUCCIMER; UNITHIOL;

EID: 0032020634     PISSN: 08953988     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (29)

1. Aposhian, H. V., Tadlock, C. H., and Moon, T. E. (1981). Protection of mice against the lethal effects of sodium arsenite: a qunatitative comparison of a number of chelating agents. Toxicol. Appl. Pharmacol. 61, 385-392.
2. Aposhian, H. V. (1983). DMSA and DMPS - water soluble antidotes for heavy metal poisoning. Annu. Rev. Pharmacol. Toxicol. 23, 193-215.
3. Aposhian, H. V. and Aposhian, M. M. (1993). Meso 2, 3-dimercaptosuccinic acid: chemical, pharmacological and toxicological properties of an orally effective metal chelating agent. Ann. Rev. Pharmacol. Toxicol. 30, 279-306.
4. Berlin, A. and Schaller, K. H. (1974). European standardized method for the determination of δ-aminolevulinic acid dehydratase activity in blood. Z. Klin. Chem. Klin. Biochem. 12, 389-390.
5. Bosque, M. A., Domingo, J. L., Llobet, J. M. and Corbella, J. (1991). Effects of meso 2,3-dimercaptosuccinic acid (DMSA) on the teratogenicity of sodium arsenate in mice. Bull. Environ. Contam. Toxicol. 47, 682-688.
6. Fiske, C. H. and Subbarow, Y. (1925). The colorimetric determination of phosphates. J. Biol. Chem. 66, 375-379.
7. Flora, S. J. S. and Kumar, P(1993). Biochemical and immunological evaluation of metal chelating drugs in rats. Drug Invest. 5, 269-273.
8. Flora, S. J. S., Bhattacharya, R., and Vijayaraghavan, R. (1995a) Combined therapeutic potential of meso 2,3-dimercaptosucccinic acid and calcium disodium edetate on the mobilization and distribution of lead in experimental lead intoxication in rats. Fund. Appl. Toxicol. 25, 233-240.
9. Flora, S. J. S., Dube, S. N., Arora, U., Kannan, G. M., Shukla, M. K., and Malhotra, P. R. (1995b). Therapeutic potential of meso 2, 3-dimercaptosuccinic acid or 2, 3-dimercaptopropane 1-sulfonate in chronic arsenic intoxication in rats. Biometals 8, 111-116.
10. Flora, G. J. S., Seth, P. K., Kannan, G. M., Pant, B. P., and Malhotra, P. R. (1996). Combined therapeutic efficacy of few thiols with calcium disodium versenate during acute lead intoxication in mice. Trace Elem. Electr. 13, 33-36.
11. Graziano, J. H., Siris, E. S., Loiacono, N. J., Silverberg, S. J. and Turgeon, L. (1985). 2,3-dimercaptosuccinic acid as an antidote for lead intoxication. Clin. Pharmacol. Ther., 37, 431-438.
12. Hilmy, A. M., El-Domiaty, N. A. E., Kamal, M. A., and Mohamed, M. A. (1991). Effects of some arsenic antagonists on the toxicity, distribution and excretion of aresenite and arsenate in rat. Comp. Biochem. Physiol. 99C, 357-362.
13. Hsueh, Y. M., Cheng, G. S., Wu, M. M., Kue T. L., and Chen, C. J. (1995). Multiple risk factors associated with arsenic induced skin cancer effects of chronic liver disease and malnutritional status. Brit. J. Cancer 71, 109-114.
14. IARC (1987). Monographs on the Evaluation of the Carcinogenic Risk to Humans: Arsenic and Arsenic Compounds (Group 1), Suppl 7, pp. 100-103. International Agency for Research in Cancer, Lyon.
15. Ishinishi, N., Tomita, M., and Hisanaga, A. (1980). Studies on chronic toxicity of arsenic in rats with special reference to liver damage. Fukuoka Acta Med. 71, 27-41.
16. Inns, R. H., Rice, P., Bright, J. E. and Marrs, T. C. (1990). Evaluation of the efficacy of dimercapto chelating agents for the treatment of systemic organic arsenic poisoning in rabbits. Human Exp. Toxicol. 9, 215-220.
17. Kipling, M. D. (1977). Arsenic. In The Chemical Environment, Environment and Man Vol. 6. (J. Lenihan and W. W. Fletcher Ed), pp. 93-120. Blackie, Glasgow.
18. Kreppel, H., Paepcke, U., Thiermann, H., Szinicz, L., Reichi, F. X., Singh, P. K., and Jones, M. M. (1993). Therapeutic efficacy of new dimercaptosuccinic acid (DMSA) analogues in acute arsenic trioxide poisoning in mice. Arch . Toxicol. 67, 580-55.
19. Maehashi, H. and Murata, Y. (1986) Arsenic excretion after treatment of arsenic poisoning with DMSA or DMPS in mice. Japan J. Pharmacol. 40, 188-190.
20. Meister, A. (1973). On the enzymology of amino acid transport. Science 180, 33-39.
21. Neiger, R. D. and Osweiler G. D. (1989). Effect of subacute low level dietary sodium arsenite on dogs. Fund. Appl. Toxicol. 13, 439-451.
22. Paredes, S. R., Kozicki, P. A., and Battle, A. M. D. (1985). S adenosyl L-methionine: A counter to lead intoxication. Comp. Biochem. Physiol. 82, 751-757.
23. Pershagen, G. (1983). The epidemiology of human arsenic exposure. In Biological and Environmental Effects of Arsenic (B. A. Fowler, Ed.), pp. 193-233. Elsevier, Amsterdam.
24. Reitman, S. and Frankel, S. (1957). A colorimeteric method for the determination of serum glutamic oxaloacetic and glutamic pyruvic transaminase. Am. J. Clin. Pathol. 28, 56-63.
25. 3. Vet. Human Toxicol. 32, 223-226.
26. Silbergeld, E. K. and Fowler, B. A. (1988). Mechanism of chemically induced porphyrinopathies. Ann. N. Y. Acad. Sci. 514, 345-351.
27. Squibb, B. A. and Fowler, B. A. (1983). The toxicity of arsenic and its compounds. In Biological and Environmental Effects of Arsenic (B. A. Fowler, Ed.), pp. 232-269. Elsevier Science Pub. B. V., Amsterdam.
28. Stramentinoli, G., Pezzoli, C., and Gallie-Kienle, M. (1979). Protective role of S-adenosyl L-methionine against acetaminophen induced mortality and heaptic toxicity in mice. Biochem. Pharmacol. 28 3567-3571.
29. World Health Organisation (1981). Environmental Health Criteria 18: Arsenic. World Health Organisation, Geneva.