GH response to GHRH combined with pyridostigmine or arginine in different conditions of low somatotrope secretion in adulthood: Obesity and Cushing's syndrome in comparison with hypopituitarism

Panminerva Medica

Volumn 40, Issue 1, 1998, Pages 13-17

  Procopio, M ^a   Maccario, M ^a   Savio, P ^a   Valetto, M R ^a   Aimaretti, G ^a   Grottoli, S ^a   Oleandri, S E ^a   Baffoni, C ^a   Tassone, F ^a   Arvat, E ^a   Camanni, F ^a   Ghigo, E ^a,b  

^a UNIVERSITY OF TURIN   (Italy)

^b UNIVERSITY OF TURIN   (Italy)

Author keywords

Cushing's syndrome; Obesity; Pyridostigmine arginine; Somatostatin; Somatotropin; Somatotropin deficiency; Somatotropin releasing hormone

Indexed keywords

ARGININE; DIAGNOSTIC AGENT; GROWTH HORMONE RELEASING FACTOR; HUMAN GROWTH HORMONE; PYRIDOSTIGMINE; SOMATOMEDIN C;

ADULT; ARTICLE; CASE CONTROL STUDY; COMPARATIVE STUDY; CUSHING SYNDROME; FEMALE; HUMAN; HYPOPITUITARISM; MALE; MIDDLE AGED; OBESITY; PATHOPHYSIOLOGY; SECRETION;

ADULT; ARGININE; CASE-CONTROL STUDIES; CUSHING SYNDROME; FEMALE; GROWTH HORMONE-RELEASING HORMONE; HUMAN GROWTH HORMONE; HUMANS; HYPOPITUITARISM; INSULIN-LIKE GROWTH FACTOR I; MALE; MIDDLE AGED; OBESITY; PYRIDOSTIGMINE BROMIDE;

EID: 0032018316     PISSN: 00310808     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (20)

1. Glass AR, Burman KD, Daahms WT, Boehm TM. Endocrine function in human obesity. Metabolism 1981;30:89-104.
2. Williams T, Berelowitz M, Joffe SN, Thorner MO, Rivier J, Vale W et al. Impaired growth hormone responses to growth hormone-releasing factor in obesity. N Engl J Med 1984:311:1403-7.
3. Cordido F, Casanueva FF, Dieguez C. Cholinergic receptor activation by piridostigmine restores growth hormone (GH) responsiveness to GH-releasing hormone administration in obese subjects: evidence for hypothalamic somatostatinergic participation in the blunted GH release of obesity. J Clin Endocrinol Metab 1989;68:290-3.
4. Veldhuis JD, Iranmanesh A, Ho KKY, Waters MJ, Johnson ML, Lizarralde G. Dual defects in pulsatile growth hormone secretion and clearances subserve the hyposomatropism of obesity in man. J Clin Endocrinol Metab 1991;72:51-9.
5. Ghigo E. Neurotransmitter control of growth hormone secretion, in: De La Cruz LF. editor. Regulation of growth hormone and somatic growth. Amsterdam: Excerpta Medica, 1992:103-36.
6. Leal-Cerro A, Pumar A, Villamil F, Astorga R, Dieguez C, Casanueva FF. Growth hormone releasing hormone increases growth hormone secretion in patients with Cushing's syndrome. Clin Endocrinol 1993;38:399-403.
7. Magiakou MA, Mastorakos G, Gomez MT, Rose SR, Chrousos GP. Suppressed spontaneous and stimulated growth hormone secretion in Cushing's disease before and after surgical cure. J Clin Endocrinol Metab 1994;78:131-7.
8. Tanaka K, Inoue S, Numata K, Okasaki H, Nakamura S, Takamura Y. Very-low-calorie diet-induced weight reduction reverses impaired growth hormone secretion response to growth hormone-releasing hormone. arginine, and L-DOPA in obesity. Metabolism 1990;39:892-6.
9. Tannenbaum GS, Lapointe M, Gurd W. Finkelstein JA. Mechanisms of impaired growth hormone secretion in genetically obese Zucker rats: roles of growth hormone-releasins factor and somatostatin. Endocrinology 1990;127:3087-95.
10. Bjorntorp P, Regional obesity In: Bjorntorp P, Brodoff BN, editors. Obesity. Philadelphia: Lippincott Company, 1992:579-86.
11. Alvarez CV, Mallo F, Burguera B, Cacicedo L, Dieguez C, Casanueva FF. Evidence for a direct pituitary inhibition by free fatty acids of in vivo growth hormone responses to growth hormone-releasing hormone in the rat. Neuroendocrinology 1991;53:185-9.
12. Rebuffe-Scrive M, Krotklewski M, Elfverson J, Bjorntorp P. Muscle and adipose tissue morphology and metabolism in Cushing's syndrome. J Endocrinol Metabol 1988;67:1122-8
13. deBoer H, Blok GJ, van der Veen. Clinical aspects of growth hormone deficiency in adults. Endocr Rev 1995;16:63-86.
14. Ghigo E, Aimaretti G, Gianotti L, Bellone J, Arvat E, Camanni F. New approach to the diagnosis growth hormone deficiency in adults. J Endocrinol 1996 (in press).
15. Thorner MO, Bengtsson BA, Ho KY et al. Diagnosis of growth hormone deficiency in adults. J Clin Endocrinol Metab 1995;80:3097-9.
16. Clemmons DR, Van Wyk JJ. Factors controlling blood concentration of Somatomedin C. Clin Endocrinol Metab 1984;13:113-43.
17. Kling MA, Rubinow DR, Doran AR. Cerebrospinal fluid immunoreactive somatostatin concentrations in patients with Cushing's disease and major depression: relationship to indices of Corticotropin-Releasing Hormone and cortisol secretion. Neuroendocrinology 1993;57:79-88.
18. Miller RG, Mimer-Brow HS. Is there an adverse interaction between corticosteroids and anticholinesterase drugs in patients with myasthenia gravis? Ann NY Acad Sci 1987;530:847-50.
19. Melmed S. Insulin suppresses growth hormone secretion by rat pituitary cells. J Clin Invest 1984;73:1425-33.
20. Hoech HC, Vestergaard P, Jakobsen PE, Laurgberg P. Test of growth hormone secretion in adults: poor reproducibility of the insulin tolerance test. Eur J Endocrinol 1995;133:305-12.