Trichosanthin inhibits T cell activation by interfering with the recruitment of ZAP-70 to CD3 ζ chain

Cell Research

Volumn 8, Issue 1, 1998, Pages 33-39

  Hong, Jian ^a   Fu, Sai Li ^a   Shen, Zhong Yi ^a   Lu, Pei Hua ^a   Chou, Kuang Yen ^a  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

PTK; TCR signaling; Trichosanthin; Tyrosine phosphorylation

Indexed keywords

ANTINEOPLASTIC AGENT; CD3 ANTIGEN; LYMPHOCYTE ANTIGEN RECEPTOR; MONOCLONAL ANTIBODY; PHOSPHOTYROSINE; PROTEIN KINASE ZAP 70; PROTEIN TYROSINE KINASE; TRICHOSANTHIN; ZAP70 PROTEIN, HUMAN;

ARTICLE; DRUG EFFECT; HUMAN; IMMUNOLOGY; LEUKEMIA CELL LINE; LYMPHOCYTE ACTIVATION; METABOLISM; SIGNAL TRANSDUCTION; T LYMPHOCYTE;

ANTIBODIES, MONOCLONAL; ANTIGENS, CD3; ANTINEOPLASTIC AGENTS, PHYTOGENIC; HUMANS; JURKAT CELLS; LYMPHOCYTE ACTIVATION; PHOSPHOTYROSINE; PROTEIN-TYROSINE KINASES; RECEPTOR-CD3 COMPLEX, ANTIGEN, T-CELL; RECEPTORS, ANTIGEN, T-CELL; SIGNAL TRANSDUCTION; T-LYMPHOCYTES; TRICHOSANTHIN; ZAP-70 PROTEIN-TYROSINE KINASE;

EID: 0032016254     PISSN: 10010602     EISSN: None     Source Type: Journal    
DOI: 10.1038/cr.1998.4     Document Type: Article

References (15)

1. Zhang JS, Lui WY. The mechanism of action of Trichosanthin on eukaryotic ribosomes-RNAN- glychsidase activity of the cytotoxin. Nucleic Acid Research 1992; 20:1271-5.
2. Yeh M, Chi YY, Shen RY, Lin GM. The study of in vitro and in vivo response to Trichosanthinin mouse. Acta Biologiae Experimentalis Sinica 1986; 19:81-6.
3. Chou KY, Zhang DQ, Xue BH. Human immune suppression is inducible by trichosanthin viaCD8 cell-mediated pathway. Cell Research 1994; 4:17-29.
4. Mayer RA, Sergios PA, Coonan K, O'Brien L. Trichosanthin treatment of HIV-induced immunedysfunction. Eur J Clin Invest 1992; 22:113-22
5. Lee-Huang S, Huang PL, Kung HF, Li BQ, Huang PL, Huang PH, Huang HI, Chen HG. TAP29:an anti-human immunodeficiency virus protein from Trichosanthin kirolowii that is non-toxic tointact cells. Proc Natl Acad Sci, USA 1991; 88:6570-4.
6. Rudd CE, Janssen O, Cai YC, da Silva AJ, Raab M, Prasad KV. Two-step TCRζ/CD3-CD4and CD28 signaling in T cells SH2/SH3 domains, protein-tyrosine and lipid kinases. ImmunolToday 1994; 15:225-34.
7. Chou KY, Chan M, Bias WB. Differential expression of the down-regulatory function of CD8cells in Trichosanthin-induced immunosuppression and its genetic control in humans. Eur JImmunogenetics 1996; 23:29-40.
8. Coligan JE, Kruisbeek AM, Margulies DH, Shevach EM, Strober W. Current protocols in immunology, by John Wiley and Sons, Inc. 1994; 11.0.1-11.5.5.
9. Hong J, Lu PH, Shen ZY, Fu SL, Chou KY. Trichosanthin suppresses the anti-CD3 mAb-inducedactivation of PKCα in lymphocytes, Shanghai J Immunol 1997; 17:327-9.
10. June CH, Fletcher MC, Ledbetter JA, Weiss A. Inhibition of tyrosine phosphorylation preventsT cell receptor-mediated signal transduction. Proc Natl Acad Sci USA 1990; 87:7722-6.
11. Chan AC, Lwashima M, Turck CW. ZAP-70: 70 kD protein-tyrosine that associates with theTCRζ chain. Cell 1992; 71:649-62.
12. Romeo C, Amiot M, Seed B. Sequence requirements for induction of cytolysis by the T cellantigen/Fc receptor ζ chain. Cell 1992; 68: 889-97.
13. Migita K, Eguchi K, Kawabe Y, Tsukada T, Ichinose Y, Nagataki S. Defective TCR-mediatedsignaling in anergic T cells. J Immunol 1995; 155:5038-87.
14. lck: dissociation. J Immunol 1995; 154:2996-3005.
15. Li NL, Zhen ZX, Shen BH, Chou KY. Modulation of T cell-mediated immune responses byTrichosanthin via antigen processing and presentation. Acta Biol Exp Sinica 1997; 30:165-71.