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Volumn 12, Issue 2, 1998, Pages 99-110
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Evaluation of proposed modes of binding of (2S)-2-[4-[[(3S)-1-acetimidoyl-3-pyrrolidinyl]oxy]phenyl]-3-(7-amidino-2- naphthyl) propanoicacid hydrochloride and some analogs to Factor Xa using a comparative molecular field analysis
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Author keywords
CoMFA; DX 9065a; Factor Xa; Systematic search
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Indexed keywords
BINDING ENERGY;
COMPUTATIONAL CHEMISTRY;
NAPHTHALENE;
PROPIONIC ACID;
BEST MODEL;
BINDING MODES;
COMFA;
COMPARATIVE MOLECULAR FIELD ANALYSIS;
DX-9065A;
FACTOR XA;
HYDROPHOBIC GROUPS;
MODE OF BINDING;
PROPANOIC ACID;
SYSTEMATIC SEARCHES;
HYDROPHOBICITY;
2 [4 [(1 ACETIMIDOYL 3 PYRROLIDINYL)OXY]PHENYL] 3 (7 AMIDINO 2 NAPHTHYL)PROPIONIC ACID;
ANTITHROMBOCYTIC AGENT;
BLOOD CLOTTING FACTOR 10A;
NAPHTHALENE DERIVATIVE;
PROPIONIC ACID DERIVATIVE;
ARTICLE;
CHEMICAL MODEL;
CHEMICAL STRUCTURE;
CHEMISTRY;
COMPARATIVE STUDY;
CRYSTALLOGRAPHY;
DRUG ANTAGONISM;
METABOLISM;
PROTEIN BINDING;
SEQUENCE ALIGNMENT;
CRYSTALLOGRAPHY;
FACTOR XA;
MODELS, CHEMICAL;
MODELS, MOLECULAR;
NAPHTHALENES;
PLATELET AGGREGATION INHIBITORS;
PROPIONIC ACIDS;
PROTEIN BINDING;
SEQUENCE ALIGNMENT;
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EID: 0032015246
PISSN: 0920654X
EISSN: None
Source Type: Journal
DOI: 10.1023/A:1007969517376 Document Type: Article |
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Times cited : (18)
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References (1)
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