Comparison of low molecular weight heparin and unfractionated heparin in the treatment of unstable angina;Heparina de bajo peso molecular versus heparina no fraccionada en el tratamiento de la angina inestable

Revista Medica de Chile

Volumn 126, Issue 3, 1998, Pages 259-264

  Godoy J, Iván ^b   Herrera C, Claudia ^b   Zapata A, Claudia ^b   Kunstmann F, Sonia ^b   Abufhele B, Alejandro ^b   Corbalán, Ramón ^a  

^a PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE   (Chile)

^b NONE

Author keywords

Angina, unstable; Heparin; Infarction; Thrombolytic therapy

Indexed keywords

ANTICOAGULANT AGENT; HEPARIN; NADROPARIN;

ADULT; AGED; ARTICLE; CLINICAL TRIAL; COMPARATIVE STUDY; FEMALE; HEART INFARCTION; HUMAN; MALE; MIDDLE AGED; RANDOMIZED CONTROLLED TRIAL; RECURRENT DISEASE; UNSTABLE ANGINA PECTORIS;

ADULT; AGED; AGED, 80 AND OVER; ANGINA, UNSTABLE; ANTICOAGULANTS; FEMALE; HEPARIN; HUMANS; MALE; MIDDLE AGED; MYOCARDIAL INFARCTION; NADROPARIN; RECURRENCE;

EID: 0032015201     PISSN: 00349887     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (17)

1. LEWIS HD JR, DAVIS JW, ARCHIBALD DG, STEIKE WE, SMITHERMAN TC, DOHERTY JE III, SCHNAPER HW, LE WINTER MM, LINARES E, POUGET JM, SABHARWAL SC, CHESLER E, DE MOTS H. Protective effects of aspirin against acute myocardial infarction and death in men with unstable angina. N Engl J Med 1983; 309: 396-403.
2. THEROUX P, OUIMET H, MCCANS J, LATOUR JG, JOLY P, LEVY G, PELLETIER E, JUNEAU M, STASIAK J, DE GUISE P, PELLETIER GB, RINZLER D, WATERS DD. Aspirin, heparin, or both to treat acute unstable angina. N Engl J Med 1988; 319: 1105-11.
3. TUEROUX P, WATERS D, QIU S, MC CANS J, GUISE P, JUNEAU M. Aspirin versus heparin to prevent myocardial infarction during the acute phase of unstable angina. Circulation 1993; 88: 2045-8.
4. VALLENTIN L, RISC GROUP. Risk of myocardial and death during treatment with low dose aspirin and intravenous heparin in men with unstable coronary artery disease. Lancet 1990; 336: 827-30.
5. GURFINKEL EP, MANOS EJ, MEJAIL RI, CERDA MA, DURONOTO EA, GAUCIA CN, DAROCA AM, MAUTNER B. Low molecular weight heparin versus regular heparin or aspirin in the treatment of unstable angina and silent ischemia. JACC 1995; 26: 313-8.
6. FRISC STUDY GROUP. Low-molecular-weight heparin during instability in coronary artery disease. Lancet 1996; 347: 561-8.
7. KLEIN W, BUCHWALD, HILLIS S, MONRAD S, SANZ G, TURPIE G, MEER JV, OLAISSON UNDELAND S, LUDWIG K, FOR THE FRIC INVESTIGATORS. Comparison of low-molecular-weight heparin with unfractionated heparin acutely and with placebo for 6 weeks in the management of unstable coronary artery disease. Fragmin in unstable coronary artery disease study (FRIC). Circulation 1997; 96: 61-8.
8. FUSTER V, BADIMON L, BADIMON JJ, CHESEBRO J. The pathogenesis of coronary artery disease and the acute coronary syndromes (first of two parts). N Engl J Med 1992; 326: 310-8.
9. FUSTER V, BADIMON L, BADIMON JJ, CHESEBRO J. The pathogenesis of coronary artery disease and the acute coronary syndromes (second of two parts). N Engl J Med 1992; 326: 310-8.
10. VINAZZER H. Advantages of low molecular weigth heparin over standard heparin: facts and fiction. SEMIN THROMB HEMOST 1991; 17: 385-8.
11. MARKWARDT F, KLOCKING HP. Heparin-induced release of plasminogen activator. Haemostasis 1977; 6: 370-4.
12. HOMER E, LINDHAL U, BACKSTROM G, ET AL. Anticoagulant activities and effect of platelets of a heparin fragment with high affinity for antithrombin. Thromb Res 1980; 18: 861-9.
13. SAMANA MM, BARA L, GEROTZIAFAS GT. Mechanisms for the antithrombotic activity in man of low molecular weight heparins. Haemostasis 1994; 24: 105-17.
14. MELANDRI G, SEMPRINI F, CERVI V, ET AL. Benefit of adding low molecular weight heparin to the conventional treatment of stable angina pectoris. A double-blind, randomized, placebo-controlled trial. Circulation 1993; 88: 2517-23.
15. BECKER RC, CANNON CP, TRACY RP, ET AL. Relation between systemic anticoagulation as determined by activited partial thromboplastin time and heparin measurements and in-hospital clinical events in unstable angina non Q wave myocardial infarction. Thrombolysis in Myocardial Ischemia IIIB Investigators. Am Heart J 1996; 131: 421-33.
16. COHEN M, DEMERS C, GURFINKEL E, TURPIE AGG, FROMELL G, GOODMAN S, LANGER A, CALIFF R, Fox KAA, PREMMEREUR J, BOGINZI F. For the efficacy and safety of subcutaneous enoxaparin in non-Q wave coronary events study group, ESSENCE Group. A comparison of low-molecular-weight heparin with unfractionated heparin for unstable coronary artery disease. N Engl J Med 1997; 337: 447-52.
17. ANTMAN E, MCCABE C, MARBLE S, CANNON C, FELDMAN R, PAPUCHIS G, MOORE P. Dose ranging trial of enoxaparin for unstable angina. Results of TIMI 11A. Circulation 1996; 94: 8 (Abstract).