Short communication: Decrease of cartilage transforming growth factor-β receptor II expression in the rabbit experimental osteoarthritis--potential role in cartilage breakdown

Osteoarthritis and Cartilage

Volumn 6, Issue 2, 1998, Pages 146-149

  Boumediene, Karim ^a   Conrozier, Thierry ^c   Mathieu, Pierre ^c   Richard, Michel ^a   Marcelli, Christian ^b   Vignon, Eric ^c   Pujol, Jean Pierre ^a  

^a UNIVERSITÉ DE CAEN   (France)

^b CHU CÔTE DE NACRE   (France)

^c NONE

Author keywords

Cartilage; Osteoarthritis; TGF receptors

Indexed keywords

GLYCAN DERIVATIVE; INTERLEUKIN 1; INTERLEUKIN 1 RECEPTOR; METALLOPROTEINASE; PROTEIN SERINE THREONINE KINASE; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; TRANSFORMING GROWTH FACTOR BETA2; MESSENGER RNA; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA TYPE II RECEPTOR; TRANSFORMING GROWTH FACTOR-BETA TYPE II RECEPTOR;

ANTERIOR CRUCIATE LIGAMENT; ARTICLE; ARTICULAR CARTILAGE; CARTILAGE CELL; CARTILAGE DEGENERATION; DOWN REGULATION; KNEE LIGAMENT; METABOLISM; OSTEOARTHRITIS; OSTEOPHYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEOGLYCAN SYNTHESIS; RABBIT; RNA TRANSCRIPTION; SIGNAL TRANSDUCTION; ANIMAL; GENETICS; HINDLIMB; JOINT; MALE; POLYMERASE CHAIN REACTION; TIME;

ANIMALS; CARTILAGE, ARTICULAR; HINDLIMB; JOINTS; MALE; OSTEOARTHRITIS; POLYMERASE CHAIN REACTION; RABBITS; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; RNA, MESSENGER; TIME FACTORS; TRANSFORMING GROWTH FACTOR BETA;

EID: 0032014292     PISSN: 10634584     EISSN: None     Source Type: Journal    
DOI: 10.1053/joca.1997.0104     Document Type: Article

References (15)

1. 1. Pujol JP, Loyau G. Interleukin-1 and osteoarthritis. Life Sci 1987;41:1187-98.
2. 2. Gowen M, Wood DD, Ihrie EJ, Meats JE, Russell RGG. Stimulation by human interleukin 1 of collagenase and proteoglycanase by human chondrocytes but not by human osteoblasts in vitro. Biochem Biophys Acta 1984;797:186-93.
3. 3. Goldring MB, Fukou K, Birkhead JR, Dudek E, Sandell LJ. Transcriptional suppression by interleukin-1 and interferon-γ of type II collagen. J Cell Biochem 1993;54:1-15.
4. 4. Benton HP, Tyler JA. Inhibition of cartilage proteoglycan synthesis by interleukin-1. Biochem Biophys Res Commun 1998;154:421-8.
5. 5. Martel-Pelletier J, Mc-Collum R, Di Battista J, Faure MP, Chin JA, Fournier S et al. The interleukin-1 receptor in normal and osteoarthritic human articular chondrocytes. Identification as the type I receptor and analysis of binding kinetics and biologic function. Arthritis Rheum 1992;35:530-40.
6. 6. van der Kraan PM, Vitters EL, van Beuningen HM, van den Berg WB. Proteoglycan synthesis and osteophyte formation in 'metabolically' and 'mechanically' induced murine degenerative joint disease : An in-vivo autoradiographic study. Int J Exp Pathol 1992;73:335-50.
7. 7. Vignon E, Bejui J, Mathieu P, Hartmann D, Ville G, Evreux JC, Descotes J. Histological cartilage changes in a rabbit model of osteoarthritis. J Rheumatol 1987;14(suppl 14):104-6.
8. 8. Pujol JP, Galéra P, Pronost S, Boumediene K, Vivien D, Macro H et al. Transforming growth factor-β (TGF-β) and articular chondrocytes. Ann Endocrinol 1994;55:109-20.
9. 9. Beuningen HM, van der Kraan PM, Armtz OJ, van den Berg WB. Transforming growth factor-β1 stimulates articular chondrocyte proteoglycan synthesis and induces osteophyte formation in the murine knee joint. Lab Invest 1994;71:279-90.
10. 10. Wrana JL, Attisano L, Wieser R, Ventura F, Massagué J. Mechanisms of activation of the TGF-β receptor. Nature 1994;370:341-7.
11. 11. Lafeber FPJG, van der Kraan PM, Huber-Bruning O, van den Berg WB, Bijlsma JWJ. Osteoarthritic human cartilage is more sensitive to transforming growth factor β than is normal cartilage. Br J Rheumatol 1993;32:281-6.
12. 12. Centrella M, Kim J, Pham T, Casinghino S, Rosen V, Wozney J, McCarthy TL. Independent changes in type I and type II receptors for transforming growth factor β induced by bone morphogenetic protein-2 parallel expression of the osteoblast phenotype. Mol Cell Biol 1995;15:3273-81.
13. 13. Sigel AV, Centrella M, Eghbali-Webb M. Regulation of proliferation response of cardiac fibroblasts by transforming growth factor-β1. J Mol Cell Cardiol 1996;28:1921-9.
14. 14. Vivien D, Rédini F, Galéra P, Lebrun E, Loyau G, Pujol JP. Rabbit articular chondrocytes (RAC) express distinct transforming growth factor-β receptor phenotypes as a function of the cell cycle. Exp Cell Res 1993;205:165-70.
15. 15. Dourado GS, Adams ME, Matyas JR, Huang D. Expression of biglycan, decorin and fibromodulin in the hypertrophic phase of experimental osteoarthritis. Osteoarth Cart 1996;4:187-96.