Effects of Sandimmune Neoral on Collagen-Induced Arthritis in DA Rats: Characterization by High Resolution Three-Dimensional Magnetic Resonance Imaging and by Histology

Journal of Magnetic Resonance

Volumn 131, Issue 1, 1998, Pages 8-16

  Beckmann, Nicolau ^a   Bruttel, Konrad ^a   Schuurman, Henk ^a   Mir, Anis ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

Author keywords

Cartilage; Collagen induced arthritis; Cyclosporine; High resolution MRI; Sandimmune neoral

Indexed keywords

ANTIINFLAMMATORY AGENT; ANTIRHEUMATIC AGENT; COLLAGEN; CYCLOSPORIN; DRUG VEHICLE; IMMUNOSUPPRESSIVE AGENT;

ANIMAL; ARTHRITIS; ARTICLE; ARTICULAR CARTILAGE; CATTLE; CHEMICALLY INDUCED DISORDER; DISEASE MODEL; FEMALE; HINDLIMB; IMMUNIZATION; INTRADERMAL DRUG ADMINISTRATION; JOINT; METATARSAL BONE; METHODOLOGY; NUCLEAR MAGNETIC RESONANCE IMAGING; ORAL DRUG ADMINISTRATION; PATHOLOGY; RAT; RAT STRAIN; VEHICLES;

ADMINISTRATION, ORAL; ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTIRHEUMATIC AGENTS; ARTHRITIS; CARTILAGE, ARTICULAR; CATTLE; COLLAGEN; CYCLOSPORINE; DISEASE MODELS, ANIMAL; FEMALE; HINDLIMB; IMMUNIZATION; IMMUNOSUPPRESSIVE AGENTS; INJECTIONS, INTRADERMAL; JOINTS; MAGNETIC RESONANCE IMAGING; METATARSAL BONES; RATS; RATS, INBRED STRAINS; VEHICLES;

EID: 0032010846     PISSN: 10907807     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmre.1997.1316     Document Type: Article

References (22)

1. N. O. Rottermich and R. L. Whisler, "Rheumatoid Arthritis," Grune & Stratton, San Diego (1985).
2. L. Klareskog, What can we learn about rheumatoid arthritis from animal models?, Springer Sem. Immunopathol. 11, 315-333 (1989).
3. J. C. Waterton, V. Rajanayagam, B. D. Ross, D. Brown, A. Whittemore, and D. Johnstone, Magnetic resonance methods for measurement of disease progression in rheumatoid arthritis, Magn. Reson. Imaging 11, 1033-1038 (1993).
4. 1-weighted sequences, Radiology 191, 413-419 (1994).
5. M. P. Recht, D. W. Piraino, G. A. Paletta, J. P. Schils, and G. H. Belhobek, Accuracy of fat-suppressed three-dimensional spoiled gradient-echo FLASH MR imaging in the detection of patellofemoral articular cartilage abnormalities, Radiology 198, 209-212 (1996).
6. N. Beckmann, K. Bruttel, A. Mir, and M. Rudin, Noninvasive 3D MR microscopy as a tool in pharmacological research: Application to a model of rheumatoid arthritis, Magn. Reson. Imaging 13, 1013-1017 (1995).
7. G. Panayi, J. S. Lanchbury, and G. H. Kingsley, The importance of the T cell in initiating and maintaining the chronic synovitis of rheumatoid arthritis, Arthritis Rheum. 35, 729-735 (1992).
8. C. Richardson and P. Emery, Clinical use of cyclosporine in rheumatoid arthritis, Drugs 50 (Suppl. 1), 26-36 (1996).
9. R. L. Wong, Mechanisms of action of cyclosporine A in animal models of rheumatoid arthritis, Inflammopharmacology 2, 177-195 (1993).
10. E. Del Pozo, M. Graeber, P. Elford, and T. Payne, Regression of bone and cartilage loss in adjuvant arthritic rats after treatment with cyclosporine A, Arthritis Rheum. 33, 247-252 (1990).
11. S. Noble and A. Markham, Cyclosporine: a review of the pharmacokinetic properties, immunosuppressive efficacy and tolerability of a microemulsion-based formulation (Neoral), Drugs 50, 924-941 (1995).
12. D. E. Trentham, A. S. Townes, and A. H. Kang, Autoimmunity to type II collagen: An experimental model of arthritis, J. Exp. Med. 77, 857-868 (1977).
13. R. Holmdahl, L. Jansson, D. Gullberg, P. O. Forsberg, K. Rubin, and L. Klareskog, Incidence of arthritis and auto-reactivity of anti-collagen antibodies after immunization of heterologous and autologous collagen II, Clin. Exp. Immunol. 62, 639-646 (1985).
14. C. M. P. Hervé-Somma, G. H. Sebag, A.-M. Prieur, V. Bonnerot, and D. P. Lallemand, Juvenile rheumatoid arthritis of the knee: MR evaluation with Gd-DOTA, Radiology 182, 93-98 (1992).
15. N. Beckmann, M. Rudin, and A. Mir, MR microscopy of the rat interphalangeal joints in vivo: Application to a model of rheumatoid arthritis, in "Proceedings, SMRM, 12th Annual Meeting, New York, 1993," p. 939.
16. G. W. Cannon, S. McCall, B. C. Cole, L. A. Radov, J. R. Ward, and M. M. Griffiths, Effects of gold sodium thiomolate, cyclosporin A, cyclophosphamide, and placebo on collagen-induced arthritis in rats, Agents Actions 38, 240-246 (1993).
17. F. E. Di Padova, Pharmacology of cyclosporine (Sandimmune). V. Pharmacological effects on immune function: In vitro studies, Pharmacol. Rev. 41, 373-406 (1989).
18. G. Russell, R. Graveley, J. Seid, A. K. al-Humidan, and H. Skodt, Mechanisms of action of cyclosporine and effects on connective tissue, Semin. Arthritis Rheum. 21 (6, Suppl. 3), 16-22 (1992).
19. C. Movsowitz, C. Epstein, M. Fallon, F. Ismail, and S. Thomas, Cyclosporine-A in vivo produces severe osteopenia in the rat: Effect of dose and duration of administration, Endocrinology 123, 2571-2577 (1988).
20. D. R. Bertolini, A. Badger, and W. High, Effect of immunomodulators on bone in the rapidly growing rat, J. Bone Miner. Res. 8 (Suppl. 1), 315 (1993).
21. E. del Pozo, K. Lippuner, W. Ruch, J. P. Casez, T. Payne, A. Mac-Kenzie, and P. Jaeger, Different effects of Cyclosporine A on bone remodeling in young and adult rats, Bone 16 (4, Supplement), 217S-275S (1995).
22. J. A. Gasser, Assessing bone quantity by pQCT, Bone 17 (4, Supplement), 145S-154S (1995).