Phase I trials in cancer patients: Participants' perceptions

European Journal of Cancer Care

Volumn 7, Issue 1, 1998, Pages 15-22

  Hutchison, Catherine ^a  

^a BEATSON WEST OF SCOTLAND CANCER CENTRE   (United Kingdom)

Author keywords

Ethics; Phase I trials; Research

Indexed keywords

ANTINEOPLASTIC AGENT;

ADULT; AGED; ARTICLE; BIOMEDICAL AND BEHAVIORAL RESEARCH; EMPIRICAL APPROACH; FEMALE; HUMAN; MALE; MEDICAL ETHICS; MIDDLE AGED; NEOPLASM; PATIENT EDUCATION; PATIENT SATISFACTION; PHASE 1 CLINICAL TRIAL; PSYCHOLOGICAL ASPECT; QUALITY OF LIFE; QUESTIONNAIRE;

BIOMEDICAL AND BEHAVIORAL RESEARCH; EMPIRICAL APPROACH;

ADULT; AGED; ANTINEOPLASTIC AGENTS; CLINICAL TRIALS, PHASE I; ETHICS, MEDICAL; FEMALE; HUMANS; MALE; MIDDLE AGED; NEOPLASMS; PATIENT EDUCATION; PATIENT SATISFACTION; QUALITY OF LIFE; QUESTIONNAIRES;

EID: 0032009828     PISSN: 09615423     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2354.1998.00062.x     Document Type: Article

References (22)

1. Baum M. (1986) Do we need informed consent? Lancet 18, 911-912.
2. Beauchamp T. & Childress J. (1989) Principles of Biomedical Ethics, 3rd edn. Oxford University Press, New York.
3. Berdel W.E., Knopf H., Fromm M. et al. (1988). Influence of phase I early clinical trials on the quality of life of cancer patients. Anticancer Research 8, 313-322.
4. Blackledge G. & Lawson F. (1992). The ethics and practical problems of phase I and II studies. In: Introducing New Treatments for Cancer: Practical, Ethical and Legal Problems (ed. Williams C.J.), pp. 137-147. John Wiley & Sons Ltd, Chichester.
5. Bujorian G.A. (1988) Clinical trials: patient issues in the decision making process. Oncology Nursing Forum 15(6), 779-783.
6. Cox K. & Avis M. (1996) Ethical and practical problems of early anti-cancer drug trials: a review of the literature. European Journal of Cancer Care 5, 90-95.
7. Emanuel E.J. (1995) Editorial. A phase I trial on the ethics on phase I trials. Journal of Clinical Oncology 13(5), 1049-1051.
8. Estey E., Hoth D., Simon R. et al. (1986). Therapeutic response in phase I trials of antineoplastic agents. Cancer Treatment Reports 70, 71-80.
9. Faulder C. (1985) Whose Body Is it? Virago Press Ltd, London.
10. Gillon R. (1992) Philosophical Medical Ethics. John Wiley & Sons, Chichester.
11. Grady C. (1991) Ethical issues in clinical trials Seminars in Oncology Nursing 7(4), 288-296.
12. Hickey S.S. (1986) Enabling hope. Cancer Nursing 9(3), 133-137.
13. Kodish E., Stocking C., Ratain M.J., Kohrman A. & Siegler M. (1992). Ethical issues in phase I oncology research; a comparison of investigators and institutional review board chairpersons. Journal of Clinical Oncology 10(11), 1810-1816.
14. Lynch M.T. (1988) The nurse's role in the biotherapy of cancer: clinical trials and informed consent. Oncology Nursing Forum 15(6) (Suppl.), 23-27.
15. MacKillop W.J. & Johnston P.A. (1986) Ethical problems in clinical research: the need for empirical studies of the clinical trials process. Journal of Chronic Diseases 39(3), 177-188.
16. McBride G. (1994). Phase I trials can exploit terminally ill patients. British Medical Journal 308, 679-680.
17. Morrow G., Gootnick J. & Schmale A. (1978) A simple technique for increasing cancer patients' knowledge of informed consent to treatment. Cancer 42, 793-799.
18. Nealon E., Blumberg B.D. & Brown B. (1985) What do patients know about clinical trials? American Journal of Nursing 85, 807-810.
19. Penman D., Holland J., Bahna G. et al. (1984) Informed consent for investigational chemotherapy: patients' and physicians' perceptions. Journal of Clinical Oncology 2(7), 849-855.
20. Rodenhuis S., van den Heuvel W.J.A., Annyas A.A. et al. (1984) Patient motivation and informed consent in a phase I study of an anticancer agent. European Journal of Cancer Clinical Oncology 20(4), 457-462.
21. Simes R.J., Tattersall M.H.N., Coates A.S. et al. (1986) Randomised comparison of procedures for obtaining informed consent in clinical trials of treatment for cancer. British Medical Journal 293, 1065-1068.
22. Tobias J.S. (1992) Informed consent and the introduction of new cancer treatments. In: Introducing New Treatments for Cancer: Practical, Ethical and Legal Problems, (ed. Williams C.J.), pp. 67-77. John Wiley & Sons Ltd, Chichester.