Dietary n-3 fatty acids in the prevention of cardiac arrhythmias

Current Opinion in Clinical Nutrition and Metabolic Care

Volumn 1, Issue 2, 1998, Pages 225-228

  Leaf, Alexander ^a   Kang, Jing X ^a   Xiao, Yong Fu ^b   Billman, George E ^c  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c OHIO STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALIA;

OMEGA 3 FATTY ACID;

ANIMAL; DRUG EFFECT; FAT INTAKE; HEART; HEART ARRHYTHMIA; HUMAN; PATHOPHYSIOLOGY; PHYSIOLOGY; REVIEW;

ANIMALS; ARRHYTHMIA; DIETARY FATS; FATTY ACIDS, OMEGA-3; HEART; HUMANS;

EID: 0032009444     PISSN: 13631950     EISSN: None     Source Type: Journal    
DOI: 10.1097/00075197-199803000-00014     Document Type: Review

References (23)

1. Gudbjarnason S, Hallgrimsson J. The role of myocardial membrane lipids in the development of cardiac necrosis. Acta Med Scand 1975; 587(Suppl): 17-26.
2. Murnaghan MF. Effects of fatty acids on the ventricular arrhythmia threshold in the isolated heart of the rabbit. Br J Pharmacol 1981; 73:909-915.
3. McLennan PL, Abeywardena MY, Charnock JS. Influence of dietary lipids on arrhythmias and infarction after coronary artery ligation in rats. Can J Physiol Pharmacol 1985; 63:1411-1417.
4. McLennan PL. Relative effects of dietary saturated, monounsaturated, and polyunsaturated fatty acids on cardiac arrhythmias in rats. Am J Clin Nutr 1993; 57:207-212.
5. McLennan PL, Bridle TM, Abeywardena MY, Charnock JS. Dietary lipid modulation of ventricular fibrillation threshold in the marmoset monkey. Am Heart J 1992; 123:1555-1561.
6. Billman GE, Kang JX, Leaf A. Prevention of ischemia-induced cardiac sudden death by n-3 polyunsaturated fatty acids in dogs. Lipids 1997; 32:1161-1168.
7. Kang JX, Leaf A. Effects of long-chain polyunsaturated fatty acids on the contraction of neonatal rat cardiac myocytes. Proc Natl Acad Sci USA 1994; 91:9886-9890.
8. Kang JX, Leaf A. Prevention and termination of the β-adrenergic agonist-induced arrhythmias by free polyunsaturated fatty acids in neonatal rat cardiac myocytes. Biochem Biophys Res Comm 1995; 208:629-636.
9. Kang JX, Leaf A. Prevention and termination of arrhythmias induced by lysophosphatidyl choline and acylcarnitine in neonatal rat cardiac myocytes by free omega-3 polyunsaturated fatty acids. Eur J Pharmacol 1996; 297:97-96.
10. Li Y, Kang JX, Leaf A. Differential effects of various eicosanoids on the production or prevention of arrhythmias in cultured neonatal rat cardiac myocytes. Prostaglandins 1997; 54:511-530.
11. Kang JX, Leaf A. Protective effect of all-trans-retinoic acid against cardiac arrhythmias induced by isoproterenol, lysophosphatidylcholine or ischemia and reperfusion. J Cardiovasc Pharmacol 1996; 297:87-106.
12. Kang JX, Xiao YF, Leaf A. Free long-chain polyunsaturated fatty acids reduce membrane electrical excitability in neonatal rat cardiac myocytes. Proc Natl Acad Sci USA 1995; 92:3997-4001.
13. + channels of neonatal rat ventricular myocytes. Proc Natl Acad Sci USA 1995; 92:11000-11004.
14. Xiao YF, Gomez AM, Morgan JP, Lederer WJ, Leaf A. Suppression of voltage-gated L-type Ca2+ currents by polyunsaturated fatty acids in adult and neonatal rat cardiac myocytes. Proc Nat Acad Sci USA 1997; 94:4182-4187.
15. + channels by directly binding to the channel proteins. Proc Natl Acad Sci USA 1996; 93:3542-3546.
16. Hallaq H, Smith TW, Leaf A. Modulation of dihydropyridine-sensitive calcium channels of heart cells by fish oil fatty acids. Proc Natl Acad Sci USA 1992; 89:1760-1764.
17. + channel. Proc Natl Acad Sci USA 1998; in press.
18. de Logeril M, Renaud S, Mamelle N, Salen P, Martin J-L, Monjaud I, et al. Mediterranean alpha-linolenic acid-rich diet in secondary prevention of coronary heart disease. Lancet 1994; 143:1454-1459.
19. Burr M, Gilbert JF, Holliday RM, Elwood PC, Fehily AM, Rogers S, et al. Effects of changes in fat, fish, and fibre intakes on death and myocardial reinfarction: diet and reinfarction trial (DART). Lancet 1989; 334:757-761.
20. American Heart Association. Heart and Stroke Facts: 1995 Statistical Supplement. Dallas: American Heart Association; 1995.
21. Lipids Research Clinics Program. The Lipid Research Clinics Coronary Primary Prevention Trial Results: I. Reduction in incidence of coronary heart disease. J Am Med Assoc 1984; 251: 351-364.
22. Siscovick DS, Raghunathan TE, King I, Weinmann S, Wicklund KG, Albright J, et al. Dietary intake and cell membrane levels of long-chain n-3 polyunsaturated fatty acids and the risk of primary cardiac arrest. J Am Med Assoc 1995; 274:1363-1367.
23. Leaf A, Weber PC. A new era for science in nutrition. Am J Clin Nutr 1987; 45:1048-1053.