Effect of environmental factors on the dominant lethality caused by expression of a mutated DnaA protein with decreased intrinsic ATPase activity

FEMS Microbiology Letters

Volumn 159, Issue 1, 1998, Pages 93-97

  Sakamoto, Kenji ^a   Makise, Masaki ^a   Tsuchiya, Tomufusa ^a   Mizushima, Tohru ^a  

^a OKAYAMA UNIVERSITY   (Japan)

Author keywords

ATPase; DnA protein; Dominant lethality; Escherichia coli

Indexed keywords

ADENOSINE TRIPHOSPHATASE; DEOXYRIBONUCLEOPROTEIN;

ARTICLE; BACTERIUM MUTANT; CELL GROWTH; COLONY FORMATION; CONTROLLED STUDY; DNA REPLICATION; ENVIRONMENTAL FACTOR; GENE EXPRESSION REGULATION; LETHAL MUTANT; LETHALITY; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL;

ADENOSINE TRIPHOSPHATASES; BACTERIAL PROTEINS; CHROMOSOMES, BACTERIAL; CULTURE MEDIA; DNA REPLICATION; DNA-BINDING PROTEINS; ESCHERICHIA COLI; GENE EXPRESSION REGULATION, BACTERIAL; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENES, BACTERIAL; GENES, DOMINANT; MUTATION; TEMPERATURE;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; NEGIBACTERIA;

EID: 0032007980     PISSN: 03781097     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-1097(97)00551-X     Document Type: Article

References (12)

1. Kornberg, A. and Baker, T.A. (1992) DNA Replication, 2nd Edn. W.H. Freeman and Company, New York.
2. Skarstad, K. and Boye, E. (1994) The initiator protein: evolution, properties and functions. Biochim. Biophys. Acta 1217, 111-130.
3. Fuller, R.S. and Kornberg, A. (1983) Purified dnaA protein in initiation of replication at the Escherichia coli chromosome origin of replication. Proc. Natl. Acad. Sci. USA 80, 5817-5821.
4. Bramhill, D. and Kornberg, A. (1988) Cell Duplex opening by dnaA protein at novel sequences in initiation of replication at the origin of the E. coli chromosome. Cell 52, 743-755.
5. Sekimizu, K., Bramhill, D. and Kornberg, A. (1987) ATP activates dnaA protein in initiating replication of plasmids bearing the origin of the E. coli chromosome. Cell 50, 259-265.
6. Mizushima, T., Sasaki, S., Ohishi, H., Kobayashi, M., Katayama, T., Miki, T., Maeda, M. and Sekimizu, K. (1996) Molecular design of inhibitors of in vitro oriC DNA replication based on the potential to block the ATP-binding of DnaA protein. J. Biol. Chem. 271, 25178-25183.
7. Mizushima, T., Nishida, S., Kurokawa, K., Katayama, T., Miki, T. and Sekimizu, K. (1997) Negative control of DNA replication by hydrolysis of ATP bound to DnaA Protein, the initiator of chromosomal DNA replication in Escherichia coli. EMBO J. 16, 3724-3730.
8. Shinpuku, T., Mizushima, T., Guo, L., Miki, T. and Sekimizu, K. (1995) Phenotypes of dnaA mutants of Escherichia coli sensitive to detergents and organic solvents. Biochem. Biophys. Res. Commun. 212, 84-89.
9. Mizushima, T., Shinpuku, T., Katayama, H., Kataoka, K., Guo, L., Miki, T. and Sekimizu, K. (1996) Phenotypes of dnaA mutants of Escherichia coli sensitive to phenothiazine derivatives. Mol. Gen. Genet. 252, 212-215.
10. Mizushima, T., Tanino, J., Miki, T. and Sekimizu, K. (1996) Decrease in the linking number of plasmid DNA in dnaA mutants of Escherichia coli. Biochem. Biophys. Res. Commun. 218, 137-141.
11. Mizushima, T., Yokoyama, K., Mima, S., Tsuchiya, T. and Sekimizu, K. (1997) Inhibition of thymidine transport in dnaA mutants of Escherichia coli. J. Biol. Chem. 272, 21195-21200.
12. Katayama, T. and Crooke, E. (1995) DnaA protein is sensitive to a soluble factor and is specifically inactivated for initiation of in vitro replication of the Escherichia coli minichromosome. J. Biol. Chem. 270, 9265-9271.