Nucleotide sequence analysis of a human monoclonal antibody 22-13 reactive with lung tumor-associated antigen

Immunology Letters

Volumn 60, Issue 2-3, 1998, Pages 111-120

  Numasaki, Muneo ^a,b   Nakamura, Kazuyasu ^c   Fukuoka, Yoshihiro ^a   Sato, Nobuyuki ^a   Saeki, Hisaaki ^b   Tachibana, Takehiko ^d   Hanai, Nobuo ^c   Nukiwa, Toshihiro ^a   Kudo, Toshio ^b  

^a Inst Devmt Aging Cancer T   (Japan)

^b Inst Devmt Aging Cancer T   (Japan)

^c KYOWA HAKKO KOGYO CO LTD   (Japan)

^d JAPAN IMMUNORESEARCH LABORATORIES   (Japan)

Author keywords

Autoimmune repertoire; Human monoclonal antibody; Rheumatoid factor; Tumor associated antigen; Variable region gene

Indexed keywords

IMMUNOGLOBULIN HEAVY CHAIN; MONOCLONAL ANTIBODY; RHEUMATOID FACTOR; TUMOR ANTIGEN;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; AUTOIMMUNITY; GENE REARRANGEMENT; HUMAN; HUMAN TISSUE; HUMORAL IMMUNITY; HYBRIDOMA; IMMUNOGLOBULIN GENE; IMMUNOGLOBULIN VARIABLE REGION; LUNG TUMOR; MOLECULAR CLONING; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SEQUENCE HOMOLOGY;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS, NEOPLASM; AUTOANTIGENS; BASE SEQUENCE; CLONING, MOLECULAR; COMPLEMENTARITY DETERMINING REGIONS; HUMANS; HYBRIDOMAS; IMMUNOGLOBULIN ALPHA-CHAINS; IMMUNOGLOBULIN D; IMMUNOGLOBULIN HEAVY CHAINS; IMMUNOGLOBULIN LIGHT CHAINS; IMMUNOGLOBULIN VARIABLE REGION; LUNG NEOPLASMS; MICE; MOLECULAR SEQUENCE DATA; TUMOR CELLS, CULTURED;

EID: 0032007803     PISSN: 01652478     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-2478(97)00141-7     Document Type: Article

References (28)

1. Numasaki M., Fukuoka Y., Kudo T. et al. A novel human monoclonal antibody, TONO-1, reactive with T-lymphocytic leukemia cells. Int. J. Cancer. 62:1995;42.
2. Kudo T., Kobayashi S., Murakami K. et al. A novel human monoclonal antibody directed to a tumor-associated antigen. Jpn. J. Cancer Res. 84:1993;760.
3. Sato N., Kudo T., Saeki H. et al. A new and efficient method to generate human IgG monoclonal antibodies reactive to cancer cells using SCID-hu mice. Immunol. Lett. 47:1995;113.
4. Pascual V., Capra J.D. Human immunoglobulin heavy-chain variable region genes: organization, polymorphism and expression. Adv. Immunol. 49:1991;1.
5. κ gene directly encodes rheumatoid factor light chain. J. Exp. Med. 164:1986;2119.
6. Youngblood K., Fruchter L., Ding G., Lopez J., Bonagura V., Davidson A. Rheumatoid factors from the peripheral blood of two patients with rheumatoid arthritis are genetically heterogeneous and somatically mutated. J. Clin. Invest. 93:1993;852.
7. H4 gene family. J. Immunol. 150:1993;2858.
8. H gene. J. Immunol. 149:1992;2234.
9. Ravetch J.V., Siebenlist U., Korsmeyer S., Waldmann T., Leder P. Structure of the human immunoglobulin μ locus: characterization of embryonic and rearranged J and D genes. Cell. 27:1981;583.
10. H genes that are homologous to human rheumatoid factors. Arthritis Rheum. 32:1989;72.
11. E.A. Kabat, T.T. Wu, H.M. Perry, K.S. Gottesman, C. Foeller, Sequences of Proteins of Immunological Interest, 5th ed., US Department of Health Human Services, Washington, DC, 1991.
12. Chothia C., Lesk A. Canonical structures for the hypervariable regions of immunoglobulins. J. Mol. Biol. 196:1987;901.
13. Schilling J., Clevinger B., Davie J.M., Hood L. Amino acid sequence of homogeneous antibodies to dextran and DNA rearrangements in heavy chain V-region gene segments. Nature. 283:1980;35.
14. Manser T., Wysocki L.J., Margolies M.N., Gefter M.L. Evolution of antibody variable region structure during the immune response. Immunol. Rev. 96:1987;141.
15. Meek K.D., Hasemann C.D., Capra J.D. Novel rearrangements at the immunoglobulin D locus. J. Exp. Med. 170:1989;39.
16. H fusions. Proc. Natl. Acad. Sci. USA. 79:1982;4118.
17. H) gene subgroups. Proc. Natl. Acad. Sci. USA. 80:1983;855.
18. Chen P.P., Robbins D.L., Jirik F.R., Kiops T.J., Carson D.A. Isolation and characterization of a light chain variable region gene for human rheumatoid factors. J. Exp. Med. 166:1987;1900.
19. Chen P.P., Albrandt K., Orida N.K. et al. Genetic basis for the cross reactive idiotypes on the light chain of human IgM anti-IgG autoantibodies. Proc. Natl. Acad. Sci. USA. 83:1986;8318.
20. Kunkel H.G., Agnello V., Joslin F.G., Winchester R.J., Capra J.D. Cross-idiotypic specificity among monoclonal IgM proteins with anti-γ globulin activity. J. Exp. Med. 137:1973;331.
21. Crouzier R., Martin T., Pasquali J.-L. Monoclonal IgM rheumatoid factor secreted by CD5-negative B-cells during mixed cryoglobulinemia. J. Immunol. 154:1995;413.
22. Amit A.G., Mariuzza R.A., Phillips S.E.V., Poijak R.J. Three-dimensional structure of an antigen-antibody complex at 2.8 Å resolution. Science. 233:1986;747.
23. H gene. J. Immunol. 149:1992;2234.
24. Kipps T.J., Tomhave E., Chen P.P., Fox R.I. Molecular characterization of a major autoantibody associated cross-reactive idiotype in Sjogren's syndrome. J. Immunol. 142:1989;4261.
25. Victor K.D., Pascual V., Lefvert A.K., Capra J.D. Human antiacetylcholine receptor antibodies use variable gene segments analogous to those used in autoantibodies of various specificities. Mol. Immunol. 29:1992;1501.
26. Pons-Estel B., Goni F., Solomom A., Frangione B. Sequence similarities among κ IIIb chains of monoclonal human IgMκ autoantibodies. J. Exp. Med. 160:1984;893.
27. Chen P.P., Fong S., Goni F. et al. Cross-reacting idiotypes on cryoprecipitating rheumatoid factor. springer semin. Immunopathology. 10:1988;35.
28. Newkirk M.M., Gram H., Heinrich G.F., Ostberg L., Capra J.D., Wasserman R.L. Complete protein sequences of the variable regions of the cloned heavy and light chains of a human anti-cytomegalovirus antibody reveal a striking similarity to human monoclonal rheumatoid factors of the Wa idiotypic family. J. Clin. Invest. 81:1988;1511.