메뉴 건너뛰기




Volumn 10, Issue 2, 1998, Pages 112-120

Anti-liver-kidney microsome-1 autoantibody in HCV-positive sera reacts predominantly to conformational epitope, not to linear epitope

Author keywords

Anti liver kidney microsome antibody (anti LKM 1); Conformational epitope; Cytochrome P450IID6 (CYP2D6)

Indexed keywords

AUTOANTIBODY; COMPLEMENTARY DNA; CYTOCHROME P450; HEPATITIS C ANTIBODY; HYBRID PROTEIN; SYNTHETIC PEPTIDE;

EID: 0032007776     PISSN: 09284346     EISSN: None     Source Type: Journal    
DOI: 10.1016/s1386-6346(97)00117-4     Document Type: Article
Times cited : (2)

References (26)
  • 1
    • 0023555290 scopus 로고
    • Chronic active hepatitis associated with anti-liver/kidney microsome antibody type 1: A second type of 'autoimmune hepatitis'
    • Homberg J.C., Abuaf N., Bernard O. et al. Chronic active hepatitis associated with anti-liver/kidney microsome antibody type 1: a second type of 'autoimmune hepatitis'. Hepatology. 7:1987;1333-1339.
    • (1987) Hepatology , vol.7 , pp. 1333-1339
    • Homberg, J.C.1    Abuaf, N.2    Bernard, O.3
  • 2
    • 0000612964 scopus 로고
    • Antibodies against human cytochrome P-450 dbl in autoimmune hepatitis type II
    • Zanger U.M., Hauri H.-P., Loeper J. et al. Antibodies against human cytochrome P-450 dbl in autoimmune hepatitis type II. Proc Natl Acad Sci USA. 27:1988;8256-8260.
    • (1988) Proc Natl Acad Sci USA , vol.27 , pp. 8256-8260
    • Zanger, U.M.1    Hauri, H.-P.2    Loeper, J.3
  • 3
    • 0024580945 scopus 로고
    • Major antigen of liver kidney microsomal auto antibodies in idiopathic autoimmune hepatitis is cytochrome P450dbl
    • Manns M.P., Johnson E.F., Griffen K.J. et al. Major antigen of liver kidney microsomal auto antibodies in idiopathic autoimmune hepatitis is cytochrome P450dbl. J Clin Invest. 83:1989;1066-1072.
    • (1989) J Clin Invest , vol.83 , pp. 1066-1072
    • Manns, M.P.1    Johnson, E.F.2    Griffen, K.J.3
  • 4
    • 0025826359 scopus 로고
    • Identification of the main epitope on human cytochrome P450IID6 recognized by anti-liver kidney microsome antibody
    • Gueguen M., Boniface O., Bernard O. et al. Identification of the main epitope on human cytochrome P450IID6 recognized by anti-liver kidney microsome antibody. J Autoimmun. 4:1991;607-615.
    • (1991) J Autoimmun , vol.4 , pp. 607-615
    • Gueguen, M.1    Boniface, O.2    Bernard, O.3
  • 5
    • 0023954396 scopus 로고
    • Human debrisoquine 4-hydroxylase (P450IID1): CDNA and deduced amino acid sequence and assignment of the CYP2D locus to chromosome 22
    • Gonzalez F.J., Vilbois F., Hardwick J.P. et al. Human debrisoquine 4-hydroxylase (P450IID1): cDNA and deduced amino acid sequence and assignment of the CYP2D locus to chromosome 22. Genomics. 2:1988;174-179.
    • (1988) Genomics , vol.2 , pp. 174-179
    • Gonzalez, F.J.1    Vilbois, F.2    Hardwick, J.P.3
  • 6
    • 0025955739 scopus 로고
    • Cytoplasmic autoantigens in autoimmune hepatitis: Molecular analysis and clinical relevance
    • Manns M.P. Cytoplasmic autoantigens in autoimmune hepatitis: molecular analysis and clinical relevance. Semin Liver Dis. 11:1991;205-214.
    • (1991) Semin Liver Dis , vol.11 , pp. 205-214
    • Manns, M.P.1
  • 7
    • 0027414305 scopus 로고
    • Identification and analysis of cytochrome P450IID6 antigenic sites recognized by anti-liver-kidney microsome type-1 antibodies(LKM1)
    • Yamamoto A.M., Cresteil D., Boniface O. et al. Identification and analysis of cytochrome P450IID6 antigenic sites recognized by anti-liver-kidney microsome type-1 antibodies(LKM1). Eur J Immunol. 23:1993;1105-1111.
    • (1993) Eur J Immunol , vol.23 , pp. 1105-1111
    • Yamamoto, A.M.1    Cresteil, D.2    Boniface, O.3
  • 8
    • 0027311972 scopus 로고
    • Anti-LKM-1 antibodies determined by use of recombinant P4502D6 in ELISA and Western blot and their association with anti-HCV and HCV-RNA
    • Seelig R., Renz M., Bunger G. et al. Anti-LKM-1 antibodies determined by use of recombinant P4502D6 in ELISA and Western blot and their association with anti-HCV and HCV-RNA. Clin Exp Immunol. 92:1993;373-380.
    • (1993) Clin Exp Immunol , vol.92 , pp. 373-380
    • Seelig, R.1    Renz, M.2    Bunger, G.3
  • 9
    • 0028038360 scopus 로고
    • Differences in immune recognition of cytochrome P4502D6 by liver kidney microsomal(LKM) antibody in autoimmune hepatitis and chronic hepatitis C virus infection
    • Ma Y., Peakman M., Lobo-Yeo A. et al. Differences in immune recognition of cytochrome P4502D6 by liver kidney microsomal(LKM) antibody in autoimmune hepatitis and chronic hepatitis C virus infection. Clin Exp Immunol. 97:1994;94-99.
    • (1994) Clin Exp Immunol , vol.97 , pp. 94-99
    • Ma, Y.1    Peakman, M.2    Lobo-Yeo, A.3
  • 10
    • 0028955702 scopus 로고
    • Heterogeneity of liver-kidney microsomal autoantibodies in chronic hepatitis C and D virus infection
    • Durazzo M., Philipp T., Van Pelt F.N.A.M. et al. Heterogeneity of liver-kidney microsomal autoantibodies in chronic hepatitis C and D virus infection. Gastroenterology. 108:1995;455-462.
    • (1995) Gastroenterology , vol.108 , pp. 455-462
    • Durazzo, M.1    Philipp, T.2    Van Pelt, F.N.A.M.3
  • 11
    • 0028954547 scopus 로고
    • Conformational epitopes on CYP2D6 are recognized by liver/kidney microsomal antibodies
    • Duclos-Vallee J.-C., Hajoui O., Yamamoto A.M. et al. Conformational epitopes on CYP2D6 are recognized by liver/kidney microsomal antibodies. Gastroenterology. 108:1995;471-476.
    • (1995) Gastroenterology , vol.108 , pp. 471-476
    • Duclos-Vallee, J.-C.1    Hajoui, O.2    Yamamoto, A.M.3
  • 13
    • 9844233168 scopus 로고    scopus 로고
    • Chronic hepatitis C associated with anti-liver/kidney microsome-1 antibody is not a subgroup of autoimmune hepatitis
    • Miyakawa H., Kitazawa E., Abe K. et al. Chronic hepatitis C associated with anti-liver/kidney microsome-1 antibody is not a subgroup of autoimmune hepatitis. J Gastroenterol 1997;32:769-76.
    • (1997) J Gastroenterol , vol.32 , pp. 769-776
    • Miyakawa, H.1    Kitazawa, E.2    Abe, K.3
  • 14
    • 0025200429 scopus 로고
    • Detection of hepatitis C virus RNA by a two-stage polymerase chain reaction with two pairs of primers deduced from the 5′-non-coding region
    • Okamoto H, Osada S, Sugiyama Y et al. Detection of hepatitis C virus RNA by a two-stage polymerase chain reaction with two pairs of primers deduced from the 5′-non-coding region. Jpn J Exp Med. 60:1990;1105-1113.
    • (1990) Jpn J Exp Med , vol.60 , pp. 1105-1113
    • Okamoto, H.1    Osada, S.2    Sugiyama, Y.3
  • 15
    • 0023854270 scopus 로고
    • Characterization of the common genetic defect in humans deficient in debrisoquine metabolism
    • Gonzalez F.J., Skoda R., Kimura S. et al. Characterization of the common genetic defect in humans deficient in debrisoquine metabolism. Nature. 331:1988;442-446.
    • (1988) Nature , vol.331 , pp. 442-446
    • Gonzalez, F.J.1    Skoda, R.2    Kimura, S.3
  • 16
    • 0027212498 scopus 로고
    • Solubilization and purification of enzymatically active glutathione-S-transferase (pGEX) fusion proteins
    • Frangioni J.V., Neel B.G. Solubilization and purification of enzymatically active glutathione-S-transferase (pGEX) fusion proteins. Anal Biochem. 210:1993;179-187.
    • (1993) Anal Biochem , vol.210 , pp. 179-187
    • Frangioni, J.V.1    Neel, B.G.2
  • 17
    • 0025992973 scopus 로고
    • LKM-1 autoantibodies recognize a short linear sequence in P450IID6, a cytochrome P-450 monooxygenase
    • Manns M.P., Griffen K.J., Sullivan K.F. et al. LKM-1 autoantibodies recognize a short linear sequence in P450IID6, a cytochrome P-450 monooxygenase. J Clin Invest. 88:1991;1370-1378.
    • (1991) J Clin Invest , vol.88 , pp. 1370-1378
    • Manns, M.P.1    Griffen, K.J.2    Sullivan, K.F.3
  • 18
    • 0030028799 scopus 로고    scopus 로고
    • Glutamic acid decarboxylase autoantibodies in stiff-man syndrome and insulin-dependent diabetes mellitus exhibit similarities and differences in epitope recognition
    • Daw K., Ujihara N., Atkinson M. et al. Glutamic acid decarboxylase autoantibodies in stiff-man syndrome and insulin-dependent diabetes mellitus exhibit similarities and differences in epitope recognition. J Immunol. 156:1996;818-825.
    • (1996) J Immunol , vol.156 , pp. 818-825
    • Daw, K.1    Ujihara, N.2    Atkinson, M.3
  • 19
    • 0025303638 scopus 로고
    • Patients with type II autoimmune hepatitis express functionally intact cytochrome P-450db-1 that is inhibited by LKM-1 autoantibodies in vitro but in vivo
    • Manns M.P., Zanger U., Gaken J. et al. Patients with type II autoimmune hepatitis express functionally intact cytochrome P-450db-1 that is inhibited by LKM-1 autoantibodies in vitro but in vivo. Hepatology. 12:1990;127-132.
    • (1990) Hepatology , vol.12 , pp. 127-132
    • Manns, M.P.1    Zanger, U.2    Gaken, J.3
  • 20
    • 0027293444 scopus 로고
    • Characterization of anti-liver kidney microsome antibody(anti-LKM1) from hepatitis C virus-positive and -negative sera
    • Yamamoto A.M., Cresteil D., Homberg J.C. et al. Characterization of anti-liver kidney microsome antibody(anti-LKM1) from hepatitis C virus-positive and -negative sera. Gastroenterology. 104:1993;1762-1767.
    • (1993) Gastroenterology , vol.104 , pp. 1762-1767
    • Yamamoto, A.M.1    Cresteil, D.2    Homberg, J.C.3
  • 21
    • 0030917657 scopus 로고    scopus 로고
    • Frequency and significance of antibodies to P450IID6 protein in Japanese patients with chronic hepatitis C
    • Nishioka M., Morshed S.A., Kono K. et al. Frequency and significance of antibodies to P450IID6 protein in Japanese patients with chronic hepatitis C. J Hepatol. 26:1997;992-1000.
    • (1997) J Hepatol , vol.26 , pp. 992-1000
    • Nishioka, M.1    Morshed, S.A.2    Kono, K.3
  • 22
    • 0028271195 scopus 로고
    • Analysis of hepatitis C virus genome in patients with autoimmune hepatitis type 2
    • Michitaka K., Durazzo M., Tillmann H.L. et al. Analysis of hepatitis C virus genome in patients with autoimmune hepatitis type 2. Gastroenterology. 106:1994;1603-1610.
    • (1994) Gastroenterology , vol.106 , pp. 1603-1610
    • Michitaka, K.1    Durazzo, M.2    Tillmann, H.L.3
  • 23
    • 0029116332 scopus 로고
    • Heterogeneity of liver/kidney microsomal antibody type 1 in autoimmune hepatitis and hepatitis C virus related liver disease
    • Muratori L., Lenzi M., Ma Y. et al. Heterogeneity of liver/kidney microsomal antibody type 1 in autoimmune hepatitis and hepatitis C virus related liver disease. Gut. 37:1995;406-412.
    • (1995) Gut , vol.37 , pp. 406-412
    • Muratori, L.1    Lenzi, M.2    Ma, Y.3
  • 24
    • 0000221972 scopus 로고
    • Reactivity of sera from Japanese patients with type 2 autoimmune hepatitis to peptides derived from host genes, cytochrome HLD8-2 and GOR
    • K. et al. Nishioka. Tokyo: Springer
    • Miyakawa H., Kako M., Usuda S. et al. Reactivity of sera from Japanese patients with type 2 autoimmune hepatitis to peptides derived from host genes, cytochrome HLD8-2 and GOR. Nishioka K. et al. Viral hepatitis and liver disease. 1994;229-231 Springer, Tokyo.
    • (1994) Viral Hepatitis and Liver Disease , pp. 229-231
    • Miyakawa, H.1    Kako, M.2    Usuda, S.3
  • 25
    • 0030990533 scopus 로고    scopus 로고
    • A new approach to cytochrome CYP2D6 antibody detection in autoimmune hepatitis type-2(AIH-2) and chronic hepatitis C virus(HCV) infection: A sensitive and quantitative radioligand assay
    • Yamamoto A.M., Johanet C., Duclos-Vallee J.-C. et al. A new approach to cytochrome CYP2D6 antibody detection in autoimmune hepatitis type-2(AIH-2) and chronic hepatitis C virus(HCV) infection: a sensitive and quantitative radioligand assay. Clin Exp Immunol. 108:1997;396-400.
    • (1997) Clin Exp Immunol , vol.108 , pp. 396-400
    • Yamamoto, A.M.1    Johanet, C.2    Duclos-Vallee, J.-C.3
  • 26
    • 0030788319 scopus 로고    scopus 로고
    • Establishment of a novel radioligand assay using eukaryotically expressed cytochrome P4502D6 for the measurement of liver kidney microsomal type 1 antibody in patients with autoimmune hepatitis and hepatitis C virus infection
    • Ma Y., Gregorio G., Gaken J. et al. Establishment of a novel radioligand assay using eukaryotically expressed cytochrome P4502D6 for the measurement of liver kidney microsomal type 1 antibody in patients with autoimmune hepatitis and hepatitis C virus infection. J Hepatol. 26:1997;1396-1402.
    • (1997) J Hepatol , vol.26 , pp. 1396-1402
    • Ma, Y.1    Gregorio, G.2    Gaken, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.