The safety of topical anaesthetic and analgesic agents in a gel when used to provide pain relief at split skin donor sites

Burns

Volumn 24, Issue 1, 1998, Pages 54-57

  Alvi, R ^a,b   Jones, S ^a   Burrows, D ^a   Collins, W ^a   McKiernan, E P ^a   Jones, R P ^a   Bunting, P ^a  

^a ROYAL PRESTON HOSPITAL   (United Kingdom)

^b WHISTON HOSPITAL   (United Kingdom)

Author keywords

Donor site; Pain; Split skin grafts

Indexed keywords

BUPIVACAINE; KETOPROFEN;

ANALGESIA; ARTICLE; BLOOD SAMPLING; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DERMIS; DONOR SITE; DOUBLE BLIND PROCEDURE; DRUG BLOOD LEVEL; GAS LIQUID CHROMATOGRAPHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; POSTOPERATIVE PAIN; RANDOMIZED CONTROLLED TRIAL; SPLIT THICKNESS SKIN GRAFT; TOPICAL DRUG ADMINISTRATION;

EID: 0032007712     PISSN: 03054179     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0305-4179(97)00090-9     Document Type: Article

References (11)

1. [1] Zapata-Sirvent, R., Hansbrough, J. F., Carroll, W. and Wakimoto, A., Comparison of biobrane and scarlet red dressings for treatment of donor site wounds. Archives of Surgery, 1985, 120, 743
2. [2] Owen, T. D. and Dye, D., The value of topical lignocaine gel in pain relief on skin graft donor sites. British Journal of Plastic Surgery, 1990, 43, 480-482.
3. [3] Koonin, A. J. and Melmed, E. P., Painless donor sites. South African Medical Journal, 1973, 47, 2241
4. [4] Bulmer, J. N. and Duckett, A. C., Absorption of lignocaine through split-skin donor sites. Anaesthesia, 1985, 40, 808-809.
5. [5] Butler, P. E. M., Eadie, P. A., Lawlord, Edwards, G. and McHugh, M., Bupivacaine and keltostat reduces post-operative donor site pain. British Journal of Plastic Surgery, 1993, 46, 523-524.
6. [6] Covino, B. G. and Vassallo, H. G., Local Anaesthetics -Mechanism of Action and Clinical Use. Grune and Stratton, New York, 1976.
7. [7] Principal, B., Clarke's Isolation and Identification of Drugs, 2nd edn. Pharmaceutical Press, London, 1986, p. 411.
8. [8] Rawal, N., Postoperative pain and its management. Annals of the Academy of Medicine, Singapore, 1994, 23, (Suppl. 6), 54-64.
9. [9] Bond, G. R., Generalised seizures and metabolic acidosis after Ketoprofen overdose. Veterinary and Human Toxicology, 1989, 31, 160
10. [10] Ishizaki, T., Sasaki, T., Suganuma, T., Horai, Y., Chiba, K., Watanabe, M., Asuke, W. and Hoshi, H., Pharmacokinetics of ketoprofen following single oral, intramuscular and rectal doses and after repeated oral administration. European Journal of Clinical Pharmacology, 1980, 18, (5). 407-414.
11. [11] Tucker, G. T. and Mather, L. E., Clinical pharmacokinetics of local anaesthetics. Clinical Pharmacokinetics, 1979, 4, 241-278.