A phase I study of daily carboplatin and simultaneous accelerated, hyperfractionated chest irradiation in patients with regionally inoperable non-small cell lung cancer

International Journal of Radiation Oncology Biology Physics

Volumn 40, Issue 3, 1998, Pages 559-567

  Kelly, Karen ^a   Hazuka, Mark ^a   Pan, Zhaozing ^a   Murphy, James ^a   Caskey, Jennifer ^b   Leonard, Charles ^a   Bunn Jr , Paul A ^a  

^a UNIVERSITY OF COLORADO CANCER CENTER   (United States)

^b Lutheran Hospital   (United States)

Author keywords

Combined modality treatment; Hyperfractionated radiotherapy and carboplatin; Lung cancer

Indexed keywords

ANTINEOPLASTIC AGENT; CARBOPLATIN;

ADULT; AGED; ARTICLE; CANCER CHEMOTHERAPY; CANCER RADIOTHERAPY; CANCER SURVIVAL; CLINICAL ARTICLE; CLINICAL TRIAL; ESOPHAGITIS; FEMALE; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; LUNG CANCER; LUNG NON SMALL CELL CANCER; MALE; NAUSEA; PHASE 1 CLINICAL TRIAL; PRIORITY JOURNAL; RADIATION DOSE FRACTIONATION; THROMBOCYTOPENIA; TREATMENT FAILURE; TREATMENT OUTCOME; VOMITING;

ADULT; AGED; ANTINEOPLASTIC AGENTS; CARBOPLATIN; CARCINOMA, NON-SMALL-CELL LUNG; COMBINED MODALITY THERAPY; DISEASE PROGRESSION; DRUG ADMINISTRATION SCHEDULE; ESOPHAGITIS; FEMALE; HUMANS; LUNG NEOPLASMS; MALE; MIDDLE AGED; NEOPLASM STAGING; NEUTROPENIA; RADIOTHERAPY DOSAGE; SURVIVAL ANALYSIS; THROMBOCYTOPENIA;

EID: 0032007012     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0360-3016(97)00769-4     Document Type: Article

References (38)

1. 1. Parker, S. L.; Tong, T.; Bolden, S.; Wingo, P. A. Cancer statistics 1997. CA Cancer J. Clin. 47:5-27; 1997.
2. 2. Holsti, L. R.; Mattson, K. A randomized study of split-course radiotherapy of lung cancer: Long term results. Int. J. Radiat. Oncol. Biol. Phys. 6:977-981; 1980.
3. 3. Lee, R. E.; Carr, D. T.; Childs, D. S., Jr. Comparison of split-course radiation therapy and continuous radiation therapy for unresectable bronchogenic carcinoma: 5 year results. Am. J. Radiol. 126:116-122; 1976.
4. 4. Perez, C. A.; Pajak, T. F.; Rubin, P. Long term observations of the patterns of failure in patients with unresectable non-oat cell carcinoma of the lung treated with definitive radiotherapy: Report by the Radiation Therapy Oncology Group. Cancer 59:1874-1881; 1987.
5. 5. Petrowich, Z.; Stanley, K.; Cox, J. D.; Paig, C. Radiotherapy in the management of locally advanced lung cancer of all cell types: Final report of randomized trial. Cancer 48:1335-1340; 1981.
6. 6. Roswit, B.; Patno, M. E.; Rapp, R. The survival of patients with inoperable lung cancer: A large scale randomized study of radiation therapy versus placebo. Radiology 90:688-697; 1968.
7. 7. Hazuka, M. B.; Bunn, P. A. Controversies in the nonsurgical treatment of stage III non-small cell lung cancer. Annu. Rev. Respir. Dis. 145:967-977; 1992.
8. 8. Pignon, J. P.; Stewart, L. A. Randomized trials of radiotherapy alone versus combined chemotherapy and radiotherapy in stages IIIa and IIIb non-small cell lung cancer: A meta-analysis. Cancer 77:2413-2414; 1996.
9. 9. Marino, P.; Preatoni, A.; Cantoni, A. Randomized trials of radiotherapy alone versus combined chemotherapy and radio-therapy in stages IIIa and IIIb non-small cell lung cancer. Cancer 76:593-601; 1995.
10. 10. Non-small Cell Lung Cancer Collaborative Group. Chemotherapy in non-small cell lung cancer: A meta-analysis using updated data on individual patients from 52 randomized clinical trials. Br. Med. J. 311:899-909; 1995.
11. 11. Pritchard, R. S.; Anthony, S. P. Chemotherapy plus radiotherapy compared with radiotherapy alone in the treatment of locally advanced, unresectable, non-small cell lung cancer. Ann. Intern. Med. 125:723-729; 1996.
12. 12. Schaake-Koning, C.; van den Bogaert, W.; Dalesio, O.; Festen, J.; Hoogenhout, J.; van Houtte, P.; Kirkpatrick, A.; Koolen, M.; Maat, B.; Nijs, A.; Renaud, A.; Rodrigus, P.; Schustee-Uitterhoeve, L.; Sculiec, J. P.; van Zandwijk, N.; Bartelink, H. Effects of concomitant cisplatin and radiotherapy on inoperable non-small cell lung cancer. N. Engl. J. Med. 326:524-529; 1992.
13. 13. Hazuka, M. B.; Crowley, J. J.; Bunn, P. A.; O'Rourke, M.; Braun, T. J.; Livingston, R. B. Daily low-dose cisplatin plus concurrent high-dose thoracic irradiation in locally advanced unresectable non-small cell lung cancer: Results of a phase II Southwest Oncology Group study. J. Clin. Oncol. 12:1814-1820; 1994.
14. 14. Thames, H. D., Jr.; Peters, L. J.; Withers, H. R.; Fletcher, G. H. Accelerated fractionation versus hyperfractionation: Rationales for several treatments per day. Int. J. Radiat. Oncol. Biol. Phys. 9:127-138; 1983.
15. 15. Cox, J. D.; Azarnia, N.; Byhardt, R. W.; Perez, C. A.; Fu, K.; Spunberg, J. J.; Sause, W. T. Altered fractionation for non-small cell carcinoma of the lung. Chest 96:68S-69S; 1989.
16. 16. Cox, J. D.; Azarnia, N.; Byhardt, R. W.; Shin, K. H.; Enami, B.; Pajak, P. F. A randomized phase I/II trial of hyperfractionated radiation therapy with total doses of 60.0 Gy to 79.2 Gy: Possible survival benefit with ≥69.6 Gy in favorable patients with Radiation Therapy Oncology Group stage III non-small cell lung carcinoma. J. Clin. Oncol. 8:1543-1555; 1990.
17. 17. Sause, W. T.; Scott, C.; Taylor, S.; Johnson, D.; Livingston, R.; Komaki, R.; Cox, J. D.; Enami, B.; Curran, W. J.; Byhardt, R. W.; Rashid Dar, A.; Turrisi, A. T. RTOG 8808 ECOG 4588, Preliminary analysis of a phase III trial in regionally advanced unresectable non-small cell lung cancer with minimum three year follow-up. Int. J. Radiat. Oncol. Biol. Phys. 3(Suppl. 1):195; 1995.
18. 18. Sause, W. T.; Scott, C.; Taylor, S.; Johnson, D.; Livingston, R.; Komaki R.; Emani, B.; Curran, W. J.; Byhardt, R. W.; Turrisi, A. T.; Rashid Dar, A.; Cox, J. D. Preliminary results of a Phase III trial in regionally advanced, unresectable non-small-cell lung cancer. J. Natl. Cancer Inst. 87:198-205; 1995.
19. 19. McGinnis, W. L.; Shaw, E. G.; Jung, S. H.; Jett, J.; Stella, P.; Marschke, R.; Kugler, J.; Mailliard, J.; Wiesenfeld, J.; Frytak, S.; Kuross, S.; Poon, M. Results of a phase III prospective randomized trial comparing standard thoracic radiation therapy (TRT) to twice daily (BID) TRT ± concomitant etoposide-cisplatin (EP) chemotherapy in patients with unresectable stage IIIA/B non-small cell lung cancer. Proc. Am. Soc. Clin. Oncol. 14:355; 1995.
20. 20. LeChevalier, T.; Arriagada, R.; Tarayre, M.; Lacombe-Terrier, M.; Laplanche, A.; Quoix, E.; Ruffie, P.; Martin, M.; Douillard, J. Significant effect of adjuvant chemotherapy on survival in locally advanced non-small cell lung carcinoma. J. Nat. Cancer Inst. 84:58; 1992.
21. 21. Bunn, P. A., Jr. Review of therapeutic trials of carboplatin in lung cancer. Semin. Oncol. 16:27-33; 1989.
22. 22. Bonomi, P. D.; Finkelstein, D. M.; Ruckdeschel, J. C.; Blum, R. H.; Green, M. D.; Mason, B.; Hahn, R.; Tormey, D. C.; Harris, J.; Comis, R. Combination chemotherapy versus single agents followed by combination chemotherapy in stage IV non-small cell lung cancer: A study of the Eastern Cooperative Oncology Group. J. Clin. Oncol. 7:1602-1613; 1989.
23. 23. Ohara, J. A.; Douple, E. B.; Richmond, E. C. Enhancement of radiation-induced cell kill by platinum complexes (carboplatin and iproplatin) in V79 cells. Int. J. Radiat. Oncol. Biol. Phys. 12:1414-1422; 1986.
24. 24. Bonomi, P. D. Brief overview of combination chemotherapy in non-small cell lung cancer. Semin. Oncol. 13:89-91; 1986.
25. 25. Longeval, E.; Klastersky, J. Combination chemotherapy with cisplatin and etoposide in bronchogenic squamous cell carcinoma and adenocarcinoma-a study for the EORTC lung cancer working party. Cancer 50:2751-2756; 1982.
26. 26. Fram, R.; Skarin, A.; Balikian, J.; Amato, D.; Leslie, N.; Malcolm, A.; Frei, E. Combination chemotherapy followed by radiation therapy in patients with regional stage III unresectable non-small cell lung cancer. Cancer Treat. Rep. 69:587-590; 1985.
27. 27. Wagner, H.; Ruckdeschel, J.; Bonomi, P.; Danjoux, C.; Richter, M.; Ettinger, D. Treatment of locally advanced non-small cell lung cancer with mitomycin-C, vinblastine, and cisplatin followed by radiation therapy: An ECOG pilot study. Proc. Am. Soc. Clin. Oncol. 4:183; 1985.
28. 28. Belani, C. P.; Slawson, R.; Hiponia, D.; Engstrom, C.; Aisner, J. Concurrent carboplatin (CBDCA) and radiotherapy (RT) for unresectable locally advanced non-small cell lung cancer. Proc. Am. Soc. Clin. Oncol. 12:355; 1993.
29. 29. Murad, A. M.; Tinoco, L. A.; Goncalves, O. X.; Prado, W. T.; Pereira, S. P. Phase II trial of carboplatin (C), mitomycin C (M) and etoposide (E) prior to concurrent radiotherapy and carboplatin in stage III non-small cell lung cancer (NSCLC). Final report. Proc. Am. Soc. Clin. Oncol. 15:387; 1996.
30. 30. Green, S.; Weiss, G. R. Southwest Oncology Group standard response criteria, endpoint definitions and toxicity criteria. Investigat. New Drugs 10:239-254; 1992.
31. 31. Kaplan, E. L.; Meier, P. Nonparametric estimation from incomplete observations. J. Am. Stat. Assoc. 53:457-481; 1958.
32. 32. Jeremic, B.; Shibamoto, Y.; Acimovic, L.; Milisavljevic, S. Hyperfractionated radiation therapy with or without concurrent low-dose daily carboplatin/etoposide for stage III nonsmall-cell lung cancer: A randomized study, J. Clin. Oncol. 14:1065-1070; 1996.
33. 33. Jeremic, B.; Shibamoto, Y.; Acimovic, L.; Djuric, L. Randomized trial of hyperfractionated radiation therapy with or without concurrent chemotherapy for stage III non-small-cell lung cancer. J. Clin. Oncol. 13:452-458; 1995.
34. 34. Jeremic, B.; Jevremovic, S.; Mijatovic, L.; Milisavljevic, S. Hyperfractionated radiation therapy with and without concurrent chemotherapy for advanced non-small cell lung cancer. Cancer 71:3732-3735; 1993.
35. 35. Ball, D.; Bishop, J.; Smith, J.; Crennan, E.; O'Brien, P.; Davis, S.; Ryan, G.; Joseph, D.; Walker, Q. A phase III study of accelerated radiotherapy with and without carboplatin in non-small cell lung cancer: An interim toxicity analysis of the first 100 patients. Int. J. Radiat. Oncol. Biol. Phys. 31:267-272; 1995.
36. 36. Watanabe, K.; Kunitoh, H.; Nagatomo, A.; Tanaka, K.; Kimbara, K. Concurrent daily carboplatin and accelerated hyperfractionated thoracic radiotherapy in locally advanced nonsmall cell lung cancer. Lung Cancer 11:177; 1994.
37. 37. Dillman, R. O.; Seagren, S. L.; Propert, K. J.; Guerra, J.; Eaton, W. L.; Perry, M. C.; Carey, R. W.; Frei, E. F.; Green, M. R. A randomized trial of induction chemotherapy plus high-dose radiation versus radiation alone in stage III nonsmall-cell lung cancer. N. Engl. J. Med. 323:940-945; 1990.
38. 38. Dillman, R. O.; Herndon, J.; Seagren, S. L.; Eaton, W. L.; Green, M. R. Improved survival in stage III non-small-cell lung cancer: Seven-year follow-up of cancer and leukemia group B (CALGB) 8433 trial. J. Natl. Cancer Inst. 88:1210-1215; 1996.