Segregation analysis reveals a major gene effect controlling systolic blood pressure and BMI in an Israeli population

Human Biology

Volumn 70, Issue 1, 1998, Pages 59-75

  Cheng, Li Shu Chuan ^a   Livshits, Gregory ^b   Carmelli, Dorit ^a   Wahrendorf, Jurgen ^c   Brunner, Daniel ^d  

^a SRI INTERNATIONAL   (United States)

^b TEL AVIV UNIVERSITY   (Israel)

^c GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^d WOLFSON MEDICAL CENTER   (Israel)

Author keywords

Bivariate Analysis; Blood Pressure; Body Mass Index; Genetic Modeling; Israelis

Indexed keywords

EID: 0032006896     PISSN: 00187143     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (45)

1. Alonso-Galicia, M., M.W. Brands, D.H. Zappe et al. 1996. Hypertension in obese Zucker rats: Role of angiotensin II and adrenergic activity. Hypertension 28:1047-1054.
2. Brunner D., J. Weisbort, N. Meshhulan et al. 1987. Relation of total cholesterol and light-density lipoprotein cholesterol percentage to the incidence of definite coronary events: Twenty-year follow-up of the Donolo-Tel Aviv prospective coronary artery disease study. Am. J. Cardiol. 59:1271-1276.
3. Cannings C., E.A. Thompson, and M.H. Skolnick. 1978. Probability functions on complex pedigrees. Adv. Appl. Prob. 10:26-61.
4. Cheng L.S.-C., D. Carmelli, S.C. Hunt et al. 1995. Evidence for a major gene influencing 7-year increases in diastolic blood pressure with age. Am. J. Hum. Genet. 57:1169-1177.
5. Cheng L.S.-C., D. Carmelli, S.C. Hunt et al. 1997. Segregation analysis of cardiovascular reactivity to laboratory stressors. Genet. Epidemiol. 14:35-49.
6. Demenais, F., M. Lathrop, and J.M. Lalouel. 1986. Robustness and power of the unified model in the analysis of quantitative measurements. Am. J. Hum. Genet. 38:228-234.
7. Dyer, A.R., P. Elliott, and M. Shipley. 1990. Body mass index versus height and weight in relation to blood pressure: Findings for the 10,079 persons in the INTERSALT study. Am. J. Epidemiol. 131:589-596.
8. Elston, R.C., and J. Stewart. 1971. A general model for the genetic analysis of pedigree data. Hum. Hered. 21:523-542.
9. Fabsitz, R.R., D. Carmelli, and J.K. Hewitt. 1992. Evidence for independent genetic influences on obesity in middle age. Int. J. Obes. 16:657-666.
10. Feinleib, M., and R.J. Garrison. 1979. The contribution of family studies to the partitioning of population variation of blood pressure. In The Genetic Analysis of Common Diseases, C.F. Sing and M. Skolnick, eds. New York: Liss, 653-673.
11. Gerber, L.M., J.E. Schwartz, P.L. Schnall et al. 1995. Body fat and fat distribution in relation to sex differences in blood pressure. Am. J. Hum. Biol. 7:173-182.
12. Ginsburg, E., G. Livshits, K. Yakovenko et al. 1997. Major gene control of human body height, weight, and BMI in five ethnically different populations. Am. J. Phys. Anthropol. (in press).
13. Go, R.C.P., R.C. Elston, and E.B. Kaplan. 1978. Efficiency and robustness of pedigree segregation analysis. Am. J. Hum. Genet. 30:28-37.
14. Hall, J.E. 1994. Renal and cardiovascular mechanisms of hypertension in obesity. Hypertension 23:381-394.
15. Hanis, C.L., C.F. Sing, W.A.R. Clarke et al. 1983. Multivariate models for human genetic analysis: Aggregation, coaggregation, and tracking of systolic blood pressure and weight. Am. J. Hum. Genet. 35:1196-1210.
16. Hasstedt, S.J. 1993. PAP: Pedigree Analysis Package, rev. 4. Salt Lake City, UT: Department of Human Genetics, University of Utah.
17. He, J., M.J. Klag, P.K. Whelton et al. 1994. Body mass index and blood pressure in a lean population in southern China. Am. J. Epidemiol. 139:380-389.
18. Hsu, P.H., F.A.L. Mathewson, and S.W. Robkin. 1977. Blood pressure and body mass index patterns: A longitudinal study. J. Chron. Dis. 30:93-113.
19. Hunt, S.C., and R.R. Williams. 1994. Genetic factors in human hypertension. In Textbook of Hypertension, J.D. Swales, ed. Oxford, England: Blackwell Scientific Publications, 519-538.
20. Hunt, S.C., S.J. Hasstedt, H. Kuida et al. 1989. Genetic heritability and common environmental components of resting and stressed blood pressures, lipids, and body mass index in Utah pedigrees and twins. Am. J. Epidemiol. 129:625-638.
21. Krieger, H., N.E. Morton, D.C. Rao et al. 1980. Familial determinants of blood pressure in northeastern Brazil. Hum. Genet. 53:415-418.
22. Kumanyika, S.K., J.R. Landis, Y.L. Matthews et al. 1994. Secular trends in blood pressure among adult blacks and whites aged 18-34 years in two body mass index strata, United States, 1960-1980. Am. J. Epidemiol. 139:141-154.
23. Lalouel, J.M. 1979. GEMINI: A Computer Program for Optimization of a Nonlinear Function. Salt Lake City, UT: Department of Medical Biophysics and Computing, University of Utah.
24. Lalouel, J.M., D.C. Rao, N.E. Morton et al. 1983. A unified model for complex segregation analysis. Am. J. Hum. Genet. 35:816-826.
25. Livshits, G., M. Blettner, E. Graff et al. 1995. Tel Aviv-Heidelberg three-generation offspring study: Genetic determinants of apolipoprotein A1 and apolipoprotein B. Am. J. Med. Genet. 57:410-416.
26. Livshits, G., G. Schettler, E. Graff et al. 1996. Tel Aviv-Heidelberg three-generation offspring study: Genetic determinants of plasma fibrinogen level. Am. J. Med. Genet. 63:509-517.
27. Livshits, G., M. Vainder, E. Graff et al. 1997. Tel Aviv-Heidelberg three-generation offspring study: Genetic and environmental sources of variation and covariation among plasma lipids lipoprotein and apolipoproteins. Am. J. Hum. Biol. 9:357-370.
28. MacDonald, A., and A.J. Stunkard. 1990. Body mass index of British separated twins. New Engl. J. Med. 322:1530.
29. MacMahon, S.W., R.B. Blacket, G.J. MacDonald et al. 1984. Obesity, alcohol consumption, and blood pressure in Australian men and women: The National Heart Foundation of Australia Risk Factor Prevalence Study. J. Hypertens. 2:85-91.
30. Marazita, M.L., R.C. Elston, K.K. Namboodiri et al. 1987. Genetic analysis of serum lipid levels and blood pressure in a large kindred. Am. J. Med. Genet. 26:511-519.
31. Neser, W.B., J. Thomas, K. Semenya et al. 1986. Obesity and hypertension in a longitudinal study of black physicians: The Meharry Cohort Study. J. Chron. Dis. 39:105-113.
32. Norman, R.A., D.E. Thompson, T. Foroud et al. 1997. Genome-wide search for genes influencing percent body fat in Pima Indians: Suggestive linkage at chromosome 11q21-q22. Am. J. Hum. Genet. 60:166-173.
33. Pérusse, L., P.P. Moll, and C.F. Sing. 1991. Evidence that a single gene with gender-and age-dependent effects influences systolic blood pressure determination in a population-based sample. Am. J. Hum. Genet. 49:94-105.
34. Pérusse, L., T. Rice, C. Bouchard et al. 1989. Cardiovascular risk factors in a French Canadian population: Resolution of genetic and familial environmental effects on blood pressure by using extensive information on environmental correlates. Am. J. Hum. Genet. 45:240-251.
35. Province, M.A., and D.C. Rao. 1985. A new model for the resolution of cultural and biological inheritance in the presence of temporal trends: Application to systolic blood pressure. Genet. Epidemiol. 2:363-374.
36. Province, M.A., P. Tishler, and D.C. Rao. 1989. Repeated-measures model for the investigation of temporal trends using longitudinal family studies: Application to systolic blood pressure. Genet. Epidemiol. 6:333-347.
37. Rice, T., C. Bouchard, I.B. Borecki et al. 1990. Commingling and segregation analysis of blood pressure in a French-Canadian population. Am. J. Hum. Genet. 46:37-44.
38. Rice, T., M. Province, L. Pérusse et al. 1994. Cross-trait familial resemblance for body fat and blood pressure: Familial correlations in the Quebec family study. Am. J. Hum. Genet. 55:1019-1029.
39. Rice, T., G.P. Vogler, L. Pérusse et al. 1989. Cardiovascular risk factors in a French Canadian population: Resolution of genetic and familial environmental effects on blood pressure using twins, adoptees, and extensive information on environmental correlates. Genet. Epidemiol. 6:571-588.
40. Schicken, R.M., M. Mosteller, M.M. Goble et al. 1992. Multivariate genetic analysis of blood pressure and body size: The Medical College of Virginia Twin Study. Circulation 86:1780-1788.
41. Sorant, A.J.M., G.E. Bonney, R.C. Elston et al. 1987. SAGE. New Orleans, LA: LSU Medical Center.
42. Stunkard, A.J., T.T. Foch, and Z. Hrubec. 1986. A twin study of human obesity. J. Am. Med. Assoc. 256:51-54.
43. Stunkard, A.J., J.R. Harris, N.L. Pederson et al. 1990. The body-mass index of twins who have been reared apart. New Engl. J. Med. 322:1438-1439.
44. Weissbecker, K.A. 1993. Segregation analysis of diastolic blood pressure in a large pedigree. Genet. Epidemiol. 10:659-664.
45. Williams, R.R., and S.C. Hunt. 1987. Recruitment of members of high-risk Utah pedigrees. Controlled Clin. Trials 8:105S-114S.