Validation of an LC-MS assay for the quantification of the enantiomers of Org 4428 in human plasma

Journal of Pharmaceutical and Biomedical Analysis

Volumn 16, Issue 6, 1998, Pages 981-989

  Paanakker, J E ^a   De Jong, J ^a   Thio, J M S L ^a   Van Hal, H J M ^a  

^a NV ORGANON   (Netherlands)

Author keywords

Antidepressant; Human plasma; LC MS; Org 4428 enantiomers; Validation

Indexed keywords

1,3,4,13B TETRAHYDRO 2,10 DIMETHYLBENZ[2,3:6,7]OXEPINO[4,5 C ]PYRIDIN 4A(2H) OL; ANTIDEPRESSANT AGENT; ORG 4428; UNCLASSIFIED DRUG;

ARTICLE; DIAGNOSTIC ACCURACY; DRUG BLOOD LEVEL; DRUG CONFORMATION; DRUG DETERMINATION; ENANTIOMER; HUMAN; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PRIORITY JOURNAL; STEREOCHEMISTRY; VALIDATION PROCESS;

ADRENERGIC UPTAKE INHIBITORS; CALIBRATION; CHROMATOGRAPHY, LIQUID; FREEZING; HUMANS; INDICATORS AND REAGENTS; MASS SPECTROMETRY; PYRIDINES; REPRODUCIBILITY OF RESULTS; STEREOISOMERISM;

EID: 0032006849     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0731-7085(97)00113-1     Document Type: Article

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