A novel drug screening assay for papillomavirus specific antiviral activity

Antiviral Research

Volumn 37, Issue 2, 1998, Pages 97-106

  Clark, Paul R ^a,b   Roberts, M Luisa ^b   Cowsert, Lex M ^b  

^a UNIVERSITY OF ARIZONA   (United States)

^b ISIS PHARMACEUTICALS   (United States)

Author keywords

Antiviral drug screening assay; DNA replication assay; Human papilloma virus type 11

Indexed keywords

AFOVIRSEN; ALPHA INTERFERON; ANTISENSE OLIGONUCLEOTIDE; ANTIVIRUS AGENT; BROXURIDINE; BUTYRIC ACID; FLUOROURACIL; ISIS 13564; ISIS 3925; RIBAVIRIN; UNCLASSIFIED DRUG; VIRUS DNA;

ANTIVIRAL ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA REPLICATION; DRUG POTENCY; DRUG SCREENING; HUMAN; HUMAN CELL; PAPILLOMA VIRUS; PRIORITY JOURNAL; VIRUS INHIBITION; VIRUS REPLICATION;

DNA VIRUSES; HUMAN PAPILLOMA VIRUS; HUMAN PAPILLOMAVIRUS; PAPILLOMAVIRUS;

EID: 0032006462     PISSN: 01663542     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0166-3542(97)00066-1     Document Type: Article

References (25)

1. Androphy, E.J., Lowy, D.R., Schiller, J.T., 1987. Bovine papillomavirus E2 trans-activating gene product binds to specific sites in papillomavirus DNA. Nature 325, 70-73.
2. Bauer, H.M., Hildesheim, A., Schiffman, M.H., Glass, A.G., Rush, B.B., Scott, D.R., Cadell, D.M., Kurman, R.J., Manos, M.M., 1993. Determinants of human papillomavirus infection in low-risk women in Portland, Oregan. Sex. Transm. Dis. 20, 274-278.
3. Beutner, K.R., Becker, T.M., Stone, K.M., 1991. Epidemiology of human papillomavirus infections. Dermatol. Clin. 9, 211-218.
4. Bonnez, W., Rose, R.C., Da Rin, C., Borkhuis, C., De Mesy Jensen, K.L., Reichman, R.C., 1993. Propagation of human papillomavirus type 11 in human xenografts using the severe combined immunodeficiency (SCID) mouse and comparison to the nude mouse model. Virology 197, 455-458.
5. Chiang, C.-M., Dong, G., Broker, T.R., Chow, L.T., 1992a. Control of human papillomavirus type 11 origin of replication by the E2 family of transcription regulatory proteins. J. Virol. 66, 5224-5231.
6. Chiang, C.-M., Ustav, M., Stenlund, A., Ho, T.F., Broker, T.R., Chow, L.T., 1992b. Viral E1 and E2 proteins support replication of homologous and heterologous papillomaviral origins. Proc. Natl. Acad. Sci. USA 89, 5799-5803.
7. Cowsert, L.M., Fox, M.C., Zon, G., Mirabelli, C.K., 1993. In vitro evaluation of phosphorothioate oligonucleotides targeted to the E2 mRNA of papillomavirus: potential treatment for genital warts. Antimicrob. Agents Chemother. 37, 171-177.
8. Cowsert, L.M., 1994. Treatment of papillomavirus infections: recent practice and future approaches. Intervirology 37, 226-230.
9. Del Vecchio, A.M., Romanczuk, H., Howley, P.M., Baker, C.C., 1992. Transient replication of human papillomavirus DNAs. J. Virol. 66, 5949-5958.
10. Ham, J., Dostatni, N., Gauthier, J.-M., Yaniv, M., 1991. The papillomavirus E2 protein: a factor with many talents. Trends Biochem. Sci. 16, 440-444.
11. Hirt, B., 1967. Selective extraction of polyomavirus DNA from infected mouse cell cultures. J. Mol. Biol. 26, 365-369.
12. Howley, P.M., 1996. Papillomavirinae: The viruses and their replication. In: Fields, B.N., Knipe, D.M., Howley, P.M., (Eds.), Fields Virology, 3rd ed. Raven, Philadelphia, pp. 2045-2076.
13. Krus, S.J., Stone, K.M., 1990. Management of genital infection by human papillomavirus. Rev. Infect. Dis. 12 (6), 620-632.
14. Lambert, P.F., Spalholz, B.A., Howley, P.M., 1987. A transcriptional repressor encoded by BPV-1 shares a common carboxy-terminal domain with E2 transactivator. Cell 50, 69-78.
15. McBride, A.A., Romanczuk, H., Howley, P.M., 1991. The papillomavirus E2 regulatory proteins. J. Biol. Chem. 266, 18411-18414.
16. Mungal, S., Steinberg, B.M., Taichman, L.B., 1992. Replication of plasmid-derived human papillomavirus type 11 DNA in cultured keratinocytes. J. Virol. 66, 3220-3324.
17. Peden, K.W., Pipas, J.M., Pearson-White, S., Nathans, D., 1980. Isolation of mutants of an animal virus in bacteria. Science 209, 1392-1396.
18. Romanczuk, H., Thierry, F., Howley, P.M., 1990. Mutational analysis of cis elements involved in E2 modulation of human papillomavirus type 16 P97 and type 18 P105 promoters. J. Virol. 64, 2849-2859.
19. Schiffman, M.H., Bauer, H.M., Hoover, R.N., Glass, A.G., Cadell, D.M., Rush, B.B., Scott, D.R., Sherman, M.E., Kurman, R.J., Wacholder, S., 1993. Epidemiologic evidence showing that human papillomavirus infection causes most cervical intraepithelial neoplasia. J. Natl. Cancer Inst. 85, 958-964.
20. Shadan, F.F., Cowsert, L.M., Villarreal, L.P., 1994. n-Butyrate, a cell cycle blocker, inhibits the replication of polyomaviruses and papillomaviruses but not that of adenoviruses and herpesviruses. J. Virol. 68, 4785-4796.
21. Turek, L.P., Byrne, J.C., Lowy, D.R., Dvoretzky, I., Friedman, R.M., Howley, P.M., 1982. Interferon induces morphological reversion with elimination of extrachromosomal viral genomes in bovine papillomavirus-transformed mouse cells. Proc. Natl. Acad. Sci. USA 79, 7914-7918.
22. Ustav, M., Stenlund, A., 1991. Transient replication of BPV-1 requires two viral polypeptides encoded by the E1 and E2 open reading frames. EMBO J. 10, 449-457.
23. Ustav, M., Ustav, P., Szymanski, P., Stenlund, A., 1991. Identification of the origin of replication of bovine papilloma virus and characterization of the viral origin replication factor E1. EMBO J. 10, 4321-4329.
24. Winokur, P.L., McBride, A.A., 1992. Separation of the transcriptional activation and replication functions of bovine papillomavirus-1 E2 protein. EMBO J. 11, 4111-4118.
25. Yang, L., Li, R., Mohr, J., Clark, R., Botchan, M.R., 1991. Activation of BPV-1 replication in vitro by the transcription factor E2. Nature 353, 628-632.