Nebulized glyceryl trinitrate exerts acute bronchodilator effects in patients with acute bronchial asthma

Pulmonary Pharmacology and Therapeutics

Volumn 11, Issue 1, 1998, Pages 65-70

  Sharara, A M ^a,c   Hijazi, M ^a   Tarawneh, M ^a   Ind, P W ^b  

^a KING HUSSEIN MEDICAL CENTER   (Jordan)

^b HAMMERSMITH HOSPITAL   (United Kingdom)

^c Youth Library   (Jordan)

Author keywords

Asthma; Bronchodilator; Glyceryl trinitrate; Inhalation; Salbutamol

Indexed keywords

GLYCERYL TRINITRATE;

ADULT; ARTICLE; ASTHMA; BODY POSTURE; BRONCHODILATATION; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DIASTOLIC BLOOD PRESSURE; DOUBLE BLIND PROCEDURE; DRUG EFFECT; DRUG MECHANISM; FEMALE; FORCED EXPIRATORY VOLUME; HEADACHE; HEART RATE; HUMAN; INHALATIONAL DRUG ADMINISTRATION; MALE; NEBULIZATION; PEAK EXPIRATORY FLOW; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SYSTOLIC BLOOD PRESSURE; VERTIGO; VITAL CAPACITY;

EID: 0032004158     PISSN: 10945539     EISSN: None     Source Type: Journal    
DOI: 10.1006/pupt.1998.0116     Document Type: Article

References (31)

1. 1. Rapoport R M, Murad F. Endothelium-dependent and nitrovasodilator-induced relaxation of vascular smooth muscle: role of cyclic GMP. J Cyclic Nucleotide Protein Phosphor Res 1983; 9: 281-296.
2. 2. Lippton H L, Gruetter C A, Ignarro L J, Meyer R L, Kadowitz P. Vasodilator actions of several N-nitroso compounds. Can J Physiol Pharmacol 1982; 60: 68-75.
3. 3. Goodman L S, Gilman A. The pharmacological basis of therapeutics. Philadelphia: Lea & Febiger, 1936.
4. 4. Kennedy T, Summer W R, Sylvester J, Robertson D. Airway response to sublingual nitroglycerin in acute asthma. JAMA 1981; 246: 145-147.
5. 5. Kochukoshy K N, Chick T W, Jenne J W. The effect of nitroglycerin in gas exchange on chronic obstructive pulmonary disease. Am Rev Respir Dis 1975; 111: 177-183.
6. 6. Radenbach D, Oltmanns D, Hell G. Nitroglycerin also as a broncholytic. Med Klin 1981; 76: 685-688.
7. 7. Okayama M, Sasaki H, Takishima T. Bronchodilator effect of sublingual isosorbide dinitrate in asthma. Eur J Clin Pharmacol 1984; 26: 151-155.
8. 8. Hirshleifer I, Arora Y. Nitrate in the treatment of bronchial asthma. Dis Chest 1961; 39: 275-283.
9. 9. Miller W C, Shultz T F. Failure of nitroglycerin as a bronchodilator. Am Rev Respir Dis 1979; 120: 471.
10. 10. Byrick R J, Hobbs E G, Martineau R, Noble W H. Nitroglycerin relaxes large airways. Anesth Analg 1983; 62: 421-425.
11. 11. Tullett W M, Patel K R. Isosorbide dinitrate and isoxsuprine in exercise induced asthma. Br Med J 1983; 286: 1934-1935.
12. 12. Angus R M, Fettes P D W, McCallum M, Thomson N. The effect of inhaled isosorbide dinitrate on exercise and histamine induced bronchoconstriction in asthma. Am J Respir Crit Care Med 1994; 149: A1058.
13. 2-agonist-induced bronchodilatation in asthmatics. Pulm Pharmacol 1995; 8: 137-141.
14. 14. Rolla G, Bucca C, Brussino L. Effect of inhaled norepinephrine on the nitroglycerine-induced bronchodilatation in asthmatics. Chest 1995; 107: 169-172.
15. 15. Gruetter C A, Barry B K, McNamara D B, Gruetter D Y, Kadowitz P J, Ignarro L. Relaxation of bovine coronary artery and activation of coronary arterial guanylate cyclase by nitric oxide, nitroprusside and a carcinogenic nitrosoamine. J Cyclic Nucleotide Res 1979; 5: 211-224.
16. 16. Bult H, Boeckxstaens G E, Pelckmans P A, Jordaens F H, Van-Maercke Y M, Herman A G. Nitric oxide as an inhibitory non-adrenergic-non-cholinergic neurotransmitter. Nature 1990; 345: 346-347.
17. 17. Luscher T F. Endogenous and exogenous nitrates and their role in myocardial ischaemia. Br J Clin Pharmacol 1992; 34 (Suppl. 1): S29-S35.
18. 18. Gruetter C A, Childers C E, Bosserman M K, Lemke S M, Ball J G, Valentovic M A. Comparison of relaxation induced by glyceryl trinitrate, isosorbide dinitrate, and sodium nitroprusside in bovine airways. Am Rev Respir Dis 1989; 139: 1192-1197.
19. 19. Barnes P. Nitric oxide and airways. Eur Respir J 1993; 6: 163-165.
20. 20. Katsuki S, Murad F. Regulation of cAMP and cGMP levels and contractility in bovine tracheal smooth muscle. Mol Pharmacol 1977; 13: 330-341.
21. 21. Jeong Y G, Battigelli M C, Bromberg P A. Effects of glyceryl trinitrate on guinea-pig tracheal smooth muscle. Am Rev Respir Dis 1978; 117: A133.
22. 22. Schreiber J. Influence of glycerol trinitrate on contractions of isolated guinea pig tracheas induced by electrical field stimulation. Z Erkr Atmungsorgane 1991; 176: 70-71.
23. 23. Masaki Y, Munakata M, Ukita H, Houma Y, Kawakami Y Nitric oxide (NO) can relax canine airway smooth muscle. Am Rev Respir Dis 1989; 139: A350.
24. 24. Aviado D M, Kishimoto T, Kneidinger H J. Bronchopulmonary effects of pentaerythrityl tetranitrate and isoproterenol. J Pharmacol Exp Ther 1969; 165: 274-285.
25. 25. Barlow W W, Beams A J. A comparison of the bronchodilating actions of several antiasthmatic agents after anaphylactic and histamine shock in the guinea pig. J Pharmacol Exp Ther 1933; 47: 111-130.
26. 26. Jamieson D D, Taylor K M. Comparison of the bronchodilator and vasodilator activity of sodium azide and sodium nitroprusside in the guinea-pig. Clin Exp Pharmacol Physiol 1979; 6: 515-525.
27. 27. Kreye V A, Marquard E. Comparison of sodium nitroprusside and isoprenaline aerosols in histamine-induced bronchial asthma of the guinea pig. Naunyn Schmiedebergs Arch Pharmacol 1979; 306: 203-207.
28. 28. Salter H H. Asthma: its pathology and treatment. Philadelphia: Blanchard & Lea, 1864: 144-150.
29. 29. Osler W. The principles and practices of medicine. New York: Appleton Press, 1892: 501.
30. 30. Goldstein J A. Nitroglycerin therapy of asthma. Chest 1984; 85: 449.
31. 31. Hogman M, Frostell C G, Hedenstrom H, Hedenstierna G. Inhalation of nitric oxide modulates adult human bronchial tone. Am Rev Respir Dis 1993; 148: 1474-1478.