CD4- and TCRαβ-positive T Lymphocytes Predominantly Infiltrated into Well-Moderately Differentiated Colon Adenocarcinoma Tissues

Japanese Journal of Clinical Oncology

Volumn 28, Issue 2, 1998, Pages 97-103

  Matsuda, Shunji ^a   Yamane, Tetsumi ^a   Hamaji, Masayasu ^a  

^a NATIONAL HOSPITAL ORGANIZATION KURE MEDICAL CENTER AND CHUGOKU CANCER CENTER   (Japan)

Author keywords

Adenocarcinoma; Colon; T lymphocyte; TCR

Indexed keywords

LYMPHOCYTE ANTIGEN RECEPTOR;

ADENOCARCINOMA; ADULT; AGED; ARTICLE; CD4 LYMPHOCYTE COUNT; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; COLON TUMOR; FEMALE; HUMAN; IMMUNOLOGY; MALE; MIDDLE AGED; PATHOLOGY; RECTUM TUMOR;

ADENOCARCINOMA; ADULT; AGED; AGED, 80 AND OVER; CD4 LYMPHOCYTE COUNT; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; COLONIC NEOPLASMS; FEMALE; HUMANS; MALE; MIDDLE AGED; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA; RECTAL NEOPLASMS;

EID: 0031990979     PISSN: 03682811     EISSN: None     Source Type: Journal    
DOI: 10.1093/jjco/28.2.97     Document Type: Article

References (19)

1. Klein JR, Mosley RL. Phenotypic and cytotoxic characteristics of intraepithelial lymphocytes. In: Kiyono H, McGee JR, editors. Advances in Host Defense Mechanisms, Vol. 9, Mucosal Immunology Intraepithelial Lymphocytes. New York: Raven Press, 1993;21-31.
2. Lefiancois L, Goodman T. In vivo modulation of cytolytic activity and Thy-1 expression in TCR-γδ intraepitherial lymphocytes Science 1989;243:1716-8.
3. Taguchi T, Aicher WK, Fujihashi K, Yamamoto M, McGhee JR, Bluestone JA, et al Novel function for intestinal intraepithelial lymphocytes Murine CD3+, γ/δ T cells produce IFN-γ and IL-5. J Immunol 1992,147:3736-44.
4. Barrett TA, Gajewslci TF, Danielpour D, Chang EB, Beagley KW, Bluestone JA. Differential function of intestinal intraepithelial lymphocyte subsets. J Immunol 1992;149:1124-1130.
5. Kaufman SHE, Blum C, Yamamoto S. Crosstalk between α/β T cells and γ/δ T cells in vivo: Activation of α/β T-cell responses after γ/δ T-cell modulation with the monoclonal antibody GL3. Proc Natl Acad Sci USA 1993;90:9620-4.
6. Momgaerts P, Amoldi J, Russ F, Tonegawa S, Kaufmann SHK. Different roles of αβ and γδ T cells in immunity against an intracellular bacterial pathogen. Nature 1993;362:53-6.
7. Lusso P, Garzino-Demo A, Crowley RW, Malnati MS. Infection of γ/δ T lymphocytes by human herpes virus 6: Transcriptional induction of CD4 and susceptibility to HIV infection. J Exp Med 1995;181:1303-10.
8. Boismenu R, Havran WL. Modulation of epithelial cell growth by intraepithelial γδ T cells. Science 1994;266:1253-5.
9. Housley RM, Morris CF, Boyle W, Ring R, Biltz R, Tarpley JT, et al. Keratinocyte growth factor induces proliferation of hepatocytes and epithelial cells throughout the rat gastrointestinal tract. J Clin Invest 1994;94:1764-77.
10. Fukushima K, Masuda T, Ohtani H, Sasaki I, Funayama Y, Matsuno S, et al Immunohistochemical characterization, distribution and ultrastructure of lymphocytes bearing the gamma/delta T-cell receptor in the human gut Virchows Arch B 1991,60:7-13.
11. Fukushima K, Masuda T, Ohtani H, Sasaki I, Funayama Y, Matsuno S, et al. Immunohistochemical characterization, distribution and ultrastructure of lymphocytes bearing the gamma/delta T-cell receptor in inflammatory bowel disease. Gastroenterology 1991,101:670-8.
12. Taunk J, Roberts AI, Ebert EC. Spontaneous cytotoxicity of human intraepitherial lymphocytes against epithelial cell tumors Gastroenterology 1992;102:69-75.
13. Roberts AI, O'Connell SM, Ebert EC. Intestinal intraepitherial lymphocytes bind to colon cancer cells by HML-1 and CD11a. Cancer Res 1993;53:1608-11.
14. MacLean IW, Nakane PK. Periodate-lysine-paraformaldehyde fixative. A new fixative for immunoelectron microscopy. J Histochem Cyochem 1974;22:1077-84.
15. Horn SS, Rosenberg SA, Topalian SL. Specific immune recognition of autologous tumor by lymphocytes infiltrating colon carcinomas: analysis by cytokine secretion. Cancer Immunol Immunother 1993;36:1-8.
16. Muller D, Killer BH, Whitton JL, Lepan KE, Brigman KK, Frelinger JA. LCMV-specific class II-restricted cytotoxic T-cells in β2 microglobulin deficient mice. Science 1992,255:1576-8.
17. Sumida T, Sakamoto A, Murata H, Makino Y, Takahashi H, Yoshida S, et al. Selective reduction of T cells bearing invariant V alpha 24J alpha Q antigen receptor in patients with systemic sclerosis. J Exp Med 1995;182:1163-8.
18. Masuda K, Makino Y, Cui J, Ito T, Tokuhisa T, Takahama Y, et al. Phenotypes and invariant alpha beta TCR expression of peripheral V alpha 14+ NK T cells. J Immunol 1997;158:2076-82.
19. Matsuda S. Increase of CD4 and TCRdβ-positive cells in colon cancer. Editor: Kondo M, My Life Co., Tokyo, Japan. Booklet: Digestive Organ and Mucosal Immunology 1966:33.