Effects of Diabetes and Difluoromethylornithine Treatment on Hyperplasia, Activity of MAP-Kinase, and Activity and Association with Cyclin B of p34cdc2 Kinase in Rat Jejunal Mucosa

Journal of Investigative Medicine

Volumn 46, Issue 2, 1998, Pages 76-81

  Parekh, Vipul V ^a,b   Hoffman, Jerald L ^a   Younoszai, M Kabir ^a  

^a University of Louisville School of Medicine   (United States)

^b UNIVERSITY OF LOUISVILLE   (United States)

Author keywords

DFMO; Diabetes; MAP K; p34cdc2; Tyrosine

Indexed keywords

CYCLIN B; CYCLIN DEPENDENT KINASE 1; EFLORNITHINE; ENZYME INHIBITOR; PROTEIN KINASE (CALCIUM,CALMODULIN);

ANIMAL; ARTICLE; DRUG EFFECT; EXPERIMENTAL DIABETES MELLITUS; HYPERPLASIA; INTESTINE MUCOSA; JEJUNUM; MALE; METABOLISM; PATHOLOGY; RAT; SPRAGUE DAWLEY RAT;

ANIMALS; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CDC2 PROTEIN KINASE; CYCLIN B; DIABETES MELLITUS, EXPERIMENTAL; EFLORNITHINE; ENZYME INHIBITORS; HYPERPLASIA; INTESTINAL MUCOSA; JEJUNUM; MALE; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0031990666     PISSN: 17088267     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (13)

1. Younoszai MK, Parekh VV, Hoffman JL. Polyamines and intestinal epithelial hyperplasia in streptozotocin-diabetic rats. Proc Soc Exp Biol Med 1993;202:206-11.
2. Younoszai MK, Parekh VV. Intestinal mucosal omithine decarboxylase and brush border membrane vesicle Na+/H+ exchange activities in diabetic rats. Proc Soc Exp Biol Med 1993;204:165-71.
3. Younoszai MK, Parekh VV, Stephen TC, Hoffman JL. Relation of ornithine decarboxylase and tyrosine kinase activity in the jejunal mucosa in civo. Proc Soc Exp Biol Med 1996;211:339-45.
4. Oliver B, Sha'afi R, Hajjar J. Transforming growth factor and epidermal growth factor activate mitogen-activated protein kinase and its substrates in intestinal epithelial cells. Proc Soc Exp Biol Med 1995;210:162-70.
5. Chen R, Sarnecki C, Blenis J., Nuclear localization and regulation of erk-and rsk- encoded protein kinases. Mol Cell Biol 1992;12:915-27.
6. Berges R, Isaac's J. Programming events in the regulation of cell proliferation and death. Clin Chem 1993;39:356-61.
7. Lowry OH, Rosenbrough NJ, Farr AL, Randall RJ. Protein measurement with the folin phenol reagent. J Biol Chem 1951;193:265-75.
8. Burton K. A study of conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid. Biochem J 1956;62:315-23.
9. Lock R, Keeling P. Responses of HeLa and Chinese Hamster ovary p34cdc2/cyclin-B kinase in relation to cell cycle perturbations enduced by etoposide. International Journal of Oncology 1993;3:33-42.
10. Faure M, Voyna-Yasenetskaya TA, Bourne HR. cAMP and a-subunits of heterotrimeric G proteins stimulate the mitogen-activated protein kinase pathway in COS-7 cells, J Biol cChem 1994;11:7851-4.
11. John Blenis. Signal transduction via the MAP kinases: proceed at your own RSK. Proc Natl Acad Sci USA 1993;90:5889-92.
12. Wang J, McCormack S, Viar M, Wang H, Tzen C, Scott R, Johnson L. Decreased expression of protooncogenes c-fos, c-myc, and c-jun following polyamine depletion in IEC-6 cells. Am J Physiol 1993;265:G331-8.
13. Morgan DM. Polyamines and cellular regulation: perspectives. Biochem Soc Trans 1990;18:1080-4.