Blood flow and glucose uptake in denervated, insulin-resistant muscles

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 274, Issue 2 43-2, 1998, Pages

  Turinsky, Jiri ^a   Damrau Abney, Alice ^a   Loegering, Daniel J ^a  

^a ALBANY MEDICAL COLLEGE   (United States)

Author keywords

2 deoxy D glucose; 51Cr labeled microspheres; Gastrocnemius muscle; Plantaris muscle; Single hindlimb denervation; Soleus muscle

Indexed keywords

ANIMAL EXPERIMENT; ARTICLE; BLOOD FLOW VELOCITY; FAST MUSCLE; GASTROCNEMIUS MUSCLE; GLUCOSE METABOLISM; GLUCOSE TRANSPORT; INSULIN RESISTANCE; MALE; MUSCLE BLOOD FLOW; MUSCLE DENERVATION; NONHUMAN; PLANTARIS MUSCLE; PRIORITY JOURNAL; RAT; SOLEUS MUSCLE; ANIMAL; INNERVATION; KINETICS; METABOLISM; SKELETAL MUSCLE; SPRAGUE DAWLEY RAT; VASCULARIZATION;

DEOXYGLUCOSE; INSULIN;

ANIMALS; DEOXYGLUCOSE; INSULIN; INSULIN RESISTANCE; KINETICS; MALE; MUSCLE DENERVATION; MUSCLE, SKELETAL; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0031990647     PISSN: 03636119     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpregu.1998.274.2.r311     Document Type: Article

References (31)

1. Ariano, M. A., R. B. Armstrong, and V. R. Edgerton. Hindlimb muscle fiber populations of five mammals. J. Histochem. Cytochem. 21: 51-55, 1973.
2. Baron, A. D. Hemodynamic actions of insulin. Am. J. Physiol. 267 (Endocrinol. Metab. 30): E187-E202, 1994.
3. Baron, A. D., G. Brechtel-Hook, A. Johnson, and D. Hardin. Skeletal muscle blood flow. A possible link between insulin resistance and blood pressure. Hypertension 21: 129-135, 1993.
4. Baron, A. D., M. Laakso, G. Brechtel, and S. V. Edelman. Mechanism of insulin resistance in insulin-dependent diabetes mellitus: a major role for reduced skeletal muscle blood flow. J. Clin. Endocrinol. Metab. 73: 637-643, 1991.
5. Baron, A. D., H. Steinberg, G. Brechtel, and A. Johnson. Skeletal muscle blood flow independently modulates insulin-mediated glucose uptake. Am. J. Physiol. 266 (Endocrinol. Metab. 29): E248-E253, 1994.
6. Burant, C. F., S. K. Lemmon, M. K. Treutelaar, and M. G. Buse. Insulin resistance of denervated rat muscle: a model for impaired receptor-function coupling. Am. J. Physiol. 247 (Endocrinol. Metab. 10): E657-E666, 1984.
7. Burant, C. F., M. K. Treutelaar, and M. G. Buse. In vitro and in vivo activation of the insulin receptor kinase in control and denervated skeletal muscle. J. Biol. Chem. 261: 8985-8993, 1986.
8. Buse, M. G., and J. Buse. Glucose uptake and the response to insulin of the isolated rat diaphragm. The effect of denervation. Diabetes 8: 218-225, 1959.
9. Buse, M. G., and J. Buse. The effect of denervation and insulin on the penetration of D-xylose into rat hemidiaphragms. Diabetes 10: 134-141, 1961.
10. Cheatham, B., and C. R. Kahn. Insulin action and the insulin signaling network. Endocr. Rev. 16: 117-142, 1995.
11. Chen, K. S., J. C. Friel, and N. B. Ruderman. Regulation of phosphatidylinositol 3-kinase by insulin in rat skeletal muscle. Am. J. Physiol. 265 (Endocrinol. Metab. 28): E736-E742, 1993.
12. Dela, F., J. J. Larsen, K. J. Mikines, and H. Galbo. Normal effect of insulin to stimulate leg blood flow in NIDDM. Diabetes , 44: 221-226, 1995.
13. Elmendorf, J. S., A. Damrau-Abney, T. R. Smith, T. S. David, and J. Turinsky. Insulin-stimulated phosphatidylinositol 3-kinase activity and 2-deoxy-D-glucose uptake in rat skeletal muscles. Biochem. Biophys. Res. Commun. 208: 1147-1153, 1995.
14. Elmendorf, J. S., A. Damrau-Abney, T. R. Smith, T. S. David, and J. Turinsky. Phosphatidylinositol 3-kinase and dynamics of insulin resistance in denervated slow and fast muscles in vivo. Am. J. Physiol. 272 (Endocrinol. Metab. 35): E661-E670, 1997.
15. Feldman, R. D., and G. S. Bierbrier. Insulin mediated vasodilation: impairment with increased blood pressure and body mass. Lancet 342: 707-709, 1993.
16. Forsayeth, J. R., and M. K. Gould. Inhibition of insulin-stimulated xylose uptake in denervated rat soleus muscle: a postreceptor effect. Diabetologia 23: 511-516, 1982.
17. Laakso, M., S. V. Edelman, G. Brechtel, and A. D. Baron. Decreased effect of insulin to stimulate skeletal muscle blood flow in obese man. A novel mechanism for insulin resistance. J. Clin. Invest. 85: 1844-1852, 1990.
18. Laakso, M., S. V. Edelman, G. Brechtel, and A. D. Baron. Impaired insulin-mediated skeletal muscle blood flow in patients with NIDDM. Diabetes 41: 1076-1083, 1992.
19. Natali, A., R. Bonadonna, D. Santoro, A. Q. Galvan, S. Baldi, S. Frascerra, C. Palombo, S. Ghione, and E. Ferrannini. Insulin resistance and vasodilation in essential hypertension. Studies with adenosine. J. Clin. Invest. 94: 1570-1576, 1994.
20. 18F]fluoro-deoxy-glucose and positron emission tomography. J. Clin. Invest. 97: 1741-1747, 1996.
21. Romanul, F. C. A. Capillary supply and metabolism of muscle fibers. Arch. Neurol. 12: 497-509, 1965.
22. Scherrer, U., D. Randin, P. Vollenweider, L. Vollenweider, and P. Nicod. Nitric oxide release accounts for insulin's vascular effects in humans. J. Clin. Invest. 94: 2511-2515, 1994.
23. Siemionow, M., T. Andreasen, L. Chick, and G. Lister. Effect of muscle flap denervation on flow hemodynamics: a new model for chronic in vivo studies. Microsurgery 15: 891-894, 1994.
24. Smith, R. L., and J. C. Lawrence, Jr. Insulin action in denervated rat hemidiaphragms. Decreased hormonal stimulation of glycogen synthesis involves both glycogen synthase and glucose transport. J. Biol. Chem. 259: 2201-2207, 1984.
25. Smith, T. R., J. S. Elmendorf, T. S. David, and J. Turinsky. Growth hormone-induced insulin resistance: role of the insulin receptor, IRS-1, GLUT-1, and GLUT-4. Am. J. Physiol. 272 (Endocrinol. Metab. 35): E1071-E1079, 1997.
26. Steinberg, H. O., G. Brechtel, A. Johnson, N. Fineberg, and A. D. Baron. Insulin-mediated skeletal muscle vasodilation is nitric oxide dependent. A novel action of insulin to increase nitric oxide release. J. Clin. Invest. 94: 1172-1179, 1994.
27. Turinsky, J. Dynamics of insulin resistance in denervated slow and fast muscles in vivo. Am. J. Physiol. 252 (Regulatory Integrative Comp. Physiol. 21): R531-R537, 1987.
28. Turinsky, J. Glucose and amino acid uptake by exercising muscles in vivo: effect of insulin, fiber population, and denervation. Endocrinology 121: 528-535, 1987.
29. Turinsky, J., I. H. Chaudry, D. J. Loegering, and K. M. Nelson. Local effect of thermal injury on skeletal muscle blood flow and nucleotide levels. Circ. Shock 8: 31-40, 1981.
30. Utriainen, T., R. Malmström, S. Mäkimattila, and H. Yki-Järvinen. Methodological aspects, dose-response characteristics and causes of interindividual variation in insulin stimulation of limb blood flow in normal subjects. Diabetologia 38: 555-564, 1995.
31. Wang, W.-Z., G. Anderson, and J. C. Firrell. Arteriole constriction following ischemia in denervated skeletal muscle. J. Reconstr. Microsurg. 11: 99-106, 1995.