Kinetics of CO2 excretion and intravascular pH disequilibria during carbonic anhydrase inhibition

Journal of Applied Physiology

Volumn 84, Issue 2, 1998, Pages 683-694

  Cardenas Jr , Victor ^a   Heming, Thomas A ^a   Bidani, Akhil ^a,b  

^a UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

^b University of Texas Medical Branch School of Medicine   (United States)

Author keywords

Acetazolamide; Carbonic anhydrase; Gas exchange

Indexed keywords

ACETAZOLAMIDE; CARBON DIOXIDE; CARBONATE DEHYDRATASE; BENZOLAMIDE; CARBONATE DEHYDRATASE INHIBITOR;

ANIMAL EXPERIMENT; ARTICLE; BLOOD PH; CAPILLARY ENDOTHELIUM; CARBON DIOXIDE EXCRETION; CONTROLLED STUDY; DOG; ENZYME INHIBITION; ERYTHROCYTE; FEMALE; LUNG DIFFUSION; LUNG GAS EXCHANGE; MALE; MATHEMATICAL MODEL; NONHUMAN; PRIORITY JOURNAL; ANIMAL; ARTIFICIAL VENTILATION; BIOLOGICAL MODEL; DRUG EFFECT; ENZYMOLOGY; HEMODYNAMICS; KINETICS; LUNG; METABOLISM; PH; PHYSIOLOGY; TIDAL VOLUME; VASCULARIZATION;

ACETAZOLAMIDE; ANIMALS; BENZOLAMIDE; CARBON DIOXIDE; CARBONIC ANHYDRASE INHIBITORS; CARBONIC ANHYDRASES; DOGS; ERYTHROCYTES; FEMALE; HEMODYNAMIC PROCESSES; HYDROGEN-ION CONCENTRATION; KINETICS; LUNG; MALE; MODELS, BIOLOGICAL; PULMONARY GAS EXCHANGE; RESPIRATION, ARTIFICIAL; TIDAL VOLUME;

EID: 0031989790     PISSN: 87507587     EISSN: None     Source Type: Journal    
DOI: 10.1152/jappl.1998.84.2.683     Document Type: Article

References (31)

1. Berthelsen, P. G., and J. O. Dich-Nielson. Respiratory function and carbonic anhydrase inhibition. Intensive Care Med. 13: 323-327, 1987.
2. 2 exchange in vivo. J. Appl. Physiol. 70: 1686-1699, 1991.
3. Bidani, A., and E. D. Crandall. Slow postcapillary changes in blood pH in vivo: titration with acetazolamide. J. Appl. Physiol. 45: 565-573, 1978.
4. 2 transfer. J. Appl. Physiol. 53: 413-418, 1982.
5. 2 transport and exchange. Appl. Cardiopulm. Pathophysiol. 2: 251-262, 1987.
6. 2 exchange. In: Respiratory Physiology: An Analytical Approach, edited by H. K. Chang and M. Paiva. New York: Dekker, 1989, vol. 40, p. 371-419. (Lung Biol. Health Ser.)
7. Bidani, A., E. D. Crandall, and R. E. Forster. Analysis of postcapillary pH changes in blood in vivo after gas exchange. J. Appl. Physiol. 44: 770-781, 1978.
8. Bidani, A., S. J. Mathew, and E. D. Crandall. Pulmonary vascular carbonic anhydrase activity. J. Appl. Physiol. 55: 75-83, 1983.
9. 2 tension in anesthetized dogs. J. Appl. Physiol. 15: 390-392, 1960.
10. Cain, S. M., and A. B. Otis. Carbon dioxide transport in anesthetized dogs during carbonic anhydrase inhibition. J. Appl. Physiol. 16: 1023-1028, 1961.
11. Chow, E. I., E. D. Crandall, and R. E. Forster. The kinetics of bicarbonate-chloride exchange across the human erythrocyte membrane. J. Gen. Physiol. 68: 633-652, 1976.
12. 2 transfer: theory. J. Appl. Physiol. 50: 265-271, 1981.
13. Crandall, E. D., A. Bidani, and R. E. Forster. Postcapillary changes in blood H in vivo during carbonic anhydrase inhibition. J. Appl. Physiol. 43: 582-590, 1977.
14. Effros, R. M., and S. Nioka. Deficiency of carbonic anhydrase in the vasculature of rabbit kidneys. J. Clin. Invest. 71: 1418-1430, 1983.
15. Federspiel, W. J. Pulmonary diffusing capacity: implications of two-phase blood flow in capillaries. Respir. Physiol. 77: 119-134, 1989.
16. Gear, C. Numerical Initial Value Problems in Ordinary Differential Equations. Englewood Cliffs, NJ: Prentice-Hall, 1971.
17. Gunn, R. B., O. Fröhlich, P. A. King, and D. G. Shoemaker. Anion transport. In: Red Cell Membranes: Structure, Function, Clinical Implications, edited by J. C. Parker and P. Agre. New York: Dekker, 1989, vol. 11, p. 563-596. (Hematol. Ser.)
18. Jacobs, M. H., and D. R. Stewart. The role of carbonic anhydrase in certain ionic exchanges involving the erythrocyte. J. Gen. Physiol. 25: 539-552, 1942.
19. Jennings, M. L. Structure and function of the red blood cell anion transport protein. Annu. Rev. Biophys. Chem. 18: 397-430, 1989.
20. Klocke, R. A. Rate of bicarbonate-chloride exchange in human red cells at 37°C. J. Appl. Physiol. 40: 707-714, 1976.
21. Klocke, R. A. Carbon dioxide transport. In: Handbook of Physiology. The Respiratory System. Gas Exchange. Bethesda, MD: Am. Physiol. Soc., 1987, sect. 3, vol. IV, chapt. 10, p. 173-198.
22. Maren, T. H. Carbonic anhydrase: chemistry, physiology and inhibition. Physiol. Rev. 47: 595-781, 1967.
23. Roughton, F. J. W. Transport of oxygen and carbon dioxide. In: Handbook of Physiology. Respiration. Washington, DC: Am. Physiol. Soc., 1964, sect. 3, vol. I, chapt. 31, p. 767-825.
24. Siggaard-Andersen, O. The Acid-Base Status of Blood (4th ed.). Baltimore, MD: Williams & Wilkins, 1974.
25. Swenson, E. R., J. Gronlund, J. Ohlsson, and M. P. Hlastala. In vivo quantitation of carbonic anhydrase and band 3 protein contributions to pulmonary gas exchange. J. Appl. Physiol. 74: 838-848, 1993.
26. 2 transport at rest and during maximal exercise. Respir. Physiol. 35: 129-159, 1978.
27. Swenson, E. R., H. T. Robertson, and M. P. Hlastala. Effects of carbonic anhydrase inhibition on ventilation-perfusion matching in the dog lung. J. Clin. Invest. 92: 702-709, 1993.
28. Taki, K., K. Hirahara, and T. Totoki. Retention of carbon dioxide in tissue following carbonic anhydrase inhibition in dogs. Clin. Ther. 15: 884-889, 1993.
29. 2 elimination in the lungs by carbonic anhydrase inhibition. Jpn. J. Physiol. 36: 523-532, 1986.
30. Wilbur, K. M., and N. G. Anderson. Electrometric and colorimetric determination of carbonic anhydrase. J. Biol. Chem. 197: 147-157, 1948.
31. 2 by the human erythrocyte. Acta Physiol. Scand. 113: 417-426, 1981.